Search Results - "Shafee, Thomas"

Convergent evolution of defensin sequence, structure and function by Shafee, Thomas M. A., Lay, Fung T., Phan, Thanh Kha, Anderson, Marilyn A., Hulett, Mark D.

“…Defensins are a well-characterised group of small, disulphide-rich, cationic peptides that are produced by essentially all eukaryotes and are highly diverse in…”
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Transcriptomics technologies by Lowe, Rohan, Shirley, Neil, Bleackley, Mark, Dolan, Stephen, Shafee, Thomas

“…Transcriptomics technologies are the techniques used to study an organism's transcriptome, the sum of all of its RNA transcripts. The information content of an…”
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The evolution, function and mechanisms of action for plant defensins by Parisi, Kathy, Shafee, Thomas M.A., Quimbar, Pedro, van der Weerden, Nicole L., Bleackley, Mark R., Anderson, Marilyn A.

“…Plant defensins are an extensive family of small cysteine rich proteins characterised by a conserved cysteine stabilised alpha beta protein fold which…”
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The Defensins Consist of Two Independent, Convergent Protein Superfamilies by Shafee, Thomas M A, Lay, Fung T, Hulett, Mark D, Anderson, Marilyn A

“…The defensin and defensin-like proteins are an extensive group of small, cationic, disulfide-rich proteins found in animals, plants, and fungi and mostly…”
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Nicotiana alata Defensin Chimeras Reveal Differences in the Mechanism of Fungal and Tumor Cell Killing and an Enhanced Antifungal Variant by Bleackley, Mark R, Payne, Jennifer A E, Hayes, Brigitte M E, Durek, Thomas, Craik, David J, Shafee, Thomas M A, Poon, Ivan K H, Hulett, Mark D, van der Weerden, Nicole L, Anderson, Marilyn A

“…The plant defensin NaD1 is a potent antifungal molecule that also targets tumor cells with a high efficiency. We examined the features of NaD1 that contribute…”
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Evolution of Sequence-Diverse Disordered Regions in a Protein Family: Order within the Chaos by Shafee, Thomas, Bacic, Antony, Johnson, Kim

“…Approaches for studying the evolution of globular proteins are now well established yet are unsuitable for disordered sequences. Our understanding of the…”
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Evolution of Wikipedia’s medical content: past, present and future by Shafee, Thomas, Masukume, Gwinyai, Kipersztok, Lisa, Das, Diptanshu, Häggström, Mikael, Heilman, James

“…As one of the most commonly read online sources of medical information, Wikipedia is an influential public health platform. Its medical content, community,…”
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Ten quick tips for editing Wikidata by Shafee, Thomas, Mietchen, Daniel, Lubiana, Tiago, Jemielniak, Dariusz, Waagmeester, Andra

“…Open, collaborative models often surprise in how productively they work in practice, given how unlikely they might be expected to work in theory. Since its…”
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Salt-Tolerant Antifungal and Antibacterial Activities of the Corn Defensin ZmD32 by Kerenga, Bomai K, McKenna, James A, Harvey, Peta J, Quimbar, Pedro, Garcia-Ceron, Donovan, Lay, Fung T, Phan, Thanh Kha, Veneer, Prem K, Vasa, Shaily, Parisi, Kathy, Shafee, Thomas M A, van der Weerden, Nicole L, Hulett, Mark D, Craik, David J, Anderson, Marilyn A, Bleackley, Mark R

“…Pathogenic microbes are developing resistance to established antibiotics, making the development of novel antimicrobial molecules paramount. One major resource…”
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The aims and scope of WikiJournal of Science by Shafee, Thomas

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Differences in protein structural regions that impact functional specificity in GT2 family β-glucan synthases by Oehme, Daniel P, Shafee, Thomas, Downton, Matthew T, Bacic, Antony, Doblin, Monika S

“…Most cell wall and secreted β-glucans are synthesised by the CAZy Glycosyltransferase 2 family (www.cazy.org), with different members catalysing the formation…”
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The plant defensin NaD1 introduces membrane disorder through a specific interaction with the lipid, phosphatidylinositol 4,5 bisphosphate by Payne, Jennifer A.E., Bleackley, Mark R., Lee, Tzong-Hsien, Shafee, Thomas M.A., Poon, Ivan K.H., Hulett, Mark D., Aguilar, Marie-Isabel, van der Weerden, Nicole L., Anderson, Marilyn A.

“…Plant defensins interact with phospholipids in bilayers as part of their cytotoxic activity. Solanaceous class II defensins with the loop 5 sequence pattern…”
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Wikidata as a knowledge graph for the life sciences by Waagmeester, Andra, Stupp, Gregory, Burgstaller-Muehlbacher, Sebastian, Good, Benjamin M, Griffith, Malachi, Griffith, Obi L, Hanspers, Kristina, Hermjakob, Henning, Hudson, Toby S, Hybiske, Kevin, Keating, Sarah M, Manske, Magnus, Mayers, Michael, Mietchen, Daniel, Mitraka, Elvira, Pico, Alexander R, Putman, Timothy, Riutta, Anders, Queralt-Rosinach, Nuria, Schriml, Lynn M, Shafee, Thomas, Slenter, Denise, Stephan, Ralf, Thornton, Katherine, Tsueng, Ginger, Tu, Roger, Ul-Hasan, Sabah, Willighagen, Egon, Wu, Chunlei, Su, Andrew I

“…Wikidata is a community-maintained knowledge base that has been assembled from repositories in the fields of genomics, proteomics, genetic variants, pathways,…”
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Fasciclin-Like Arabinogalactan-Protein 16 (FLA16) Is Required for Stem Development in Arabidopsis by Liu, Edgar, MacMillan, Colleen P, Shafee, Thomas, Ma, Yingxuan, Ratcliffe, Julian, van de Meene, Allison, Bacic, Antony, Humphries, John, Johnson, Kim L

“…The predominant Fascilin 1 (FAS1)-containing proteins in plants belong to the Fasciclin-Like Arabinogalactan-protein (FLA) family of extracellular…”
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Structural homology guided alignment of cysteine rich proteins by Shafee, Thomas M. A., Robinson, Andrew J., van der Weerden, Nicole, Anderson, Marilyn A.

“…Background Cysteine rich protein families are notoriously difficult to align due to low sequence identity and frequent insertions and deletions. Results Here…”
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Histidine-Rich Defensins from the Solanaceae and Brasicaceae Are Antifungal and Metal Binding Proteins by Bleackley, Mark R, Vasa, Shaily, Harvey, Peta J, Shafee, Thomas M.A, da Costa, Tatiana P. Soares, Craik, David J, Lowe, Rohan G.T, Anderson, Marilyn A

“…Plant defensins are best known for their antifungal activity and contribution to the plant immune system. The defining feature of plant defensins is their…”
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Genomic, functional and structural analyses elucidate evolutionary innovation within the sea anemone 8 toxin family by Ashwood, Lauren M, Elnahriry, Khaled A, Stewart, Zachary K, Shafee, Thomas, Naseem, Muhammad Umair, Szanto, Tibor G, van der Burg, Chloé A, Smith, Hayden L, Surm, Joachim M, Undheim, Eivind A B, Madio, Bruno, Hamilton, Brett R, Guo, Shaodong, Wai, Dorothy C C, Coyne, Victoria L, Phillips, Matthew J, Dudley, Kevin J, Hurwood, David A, Panyi, Gyorgy, King, Glenn F, Pavasovic, Ana, Norton, Raymond S, Prentis, Peter J

“…The ShK toxin from Stichodactyla helianthus has established the therapeutic potential of sea anemone venom peptides, but many lineage-specific toxin families…”
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Medical journals and Wikipedia: a global health matter by Masukume, Gwinyai, Kipersztok, Lisa, Das, Diptanshu, Shafee, Thomas M A, Laurent, Michaël R, Heilman, James M

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Hyperpolarisation of Mitochondrial Membranes Is a Critical Component of the Antifungal Mechanism of the Plant Defensin, Ppdef1 by Parisi, Kathy, McKenna, James A, Lowe, Rohan, Harris, Karen S, Shafee, Thomas, Guarino, Rosemary, Lee, Eunice, van der Weerden, Nicole L, Bleackley, Mark R, Anderson, Marilyn A

“…Plant defensins are a large family of small cationic proteins with diverse functions and mechanisms of action, most of which assert antifungal activity against…”
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Using logical constraints to validate statistical information about disease outbreaks in collaborative knowledge graphs: the case of COVID-19 epidemiology in Wikidata by Turki, Houcemeddine, Jemielniak, Dariusz, Hadj Taieb, Mohamed A, Labra Gayo, Jose E, Ben Aouicha, Mohamed, Banat, Mus'ab, Shafee, Thomas, Prud'hommeaux, Eric, Lubiana, Tiago, Das, Diptanshu, Mietchen, Daniel

“…Urgent global research demands real-time dissemination of precise data. Wikidata, a collaborative and openly licensed knowledge graph available in RDF format,…”
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