Search Results - "Shader, R I"

CYP2B6 Mediates the In Vitro Hydroxylation of Bupropion: Potential Drug Interactions with Other Antidepressants by HESSE, Leah M, VENKATAKRISHNAN, Karthik, COURT, Michael H, VON MOLTKE, Lisa L, DUAN, S. U. X, SHADER, Richard I, GREENBLATT, David J

“…The in vitro biotransformation of bupropion to hydroxybupropion was studied in human liver microsomes and microsomes containing heterologously expressed human…”
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In Vitro Approaches to Predicting Drug Interactions In Vivo by von Moltke, Lisa L, Greenblatt, David J, Schmider, Jürgen, Wright, C.Eugene, Harmatz, Jerold S, Shader, Richard I

“…In vitro metabolic models using human liver microsomes can be applied to quantitative prediction of in vivo drug interactions caused by reversible inhibition…”
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Protease Inhibitors as Inhibitors of Human Cytochromes P450: High Risk Associated with Ritonavir by von Moltke, Lisa L., Greenblatt, David J., Grassi, Jeffrey M., Granda, Brian W., Duan, Su Xiang, Fogelman, Steven M., Daily, Johanna P., Harmatz, Jerold S., Shader, Richard I.

“…Four protease inhibitor antiviral agents (ritonavir, indinavir, nelfinavir, saquinavir) were evaluated as in vitro inhibitors of the activity of six human…”
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Escitalopram (S-Citalopram) and Its Metabolites in Vitro: Cytochromes Mediating Biotransformation, Inhibitory Effects, and Comparison to R-Citalopram by VON MOLTKE, Lisa L, GREENBLATT, David J, GIANCARLO, Gina M, GRANDA, Brian W, HARMATZ, Jerold S, SHADER, Richard I

“…Transformation of escitalopram ( S -CT), the pharmacologically active S -enantiometer of citalopram, to S -desmethyl-CT ( S -DCT), and of S -DCT to S…”
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Inhibition of desipramine hydroxylation in vitro by serotonin-reuptake-inhibitor antidepressants, and by quinidine and ketoconazole: a model system to predict drug interactions in vivo by von Moltke, L L, Greenblatt, D J, Cotreau-Bibbo, M M, Duan, S X, Harmatz, J S, Shader, R I

“…Biotransformation of the tricyclic antidepressant desipramine (DMI) to its metabolite 2-hydroxy-desipramine (2-OH-DMI) was studied in vitro using microsomal…”
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O- and N-demethylation of Venlafaxine In Vitro by Human Liver Microsomes and by Microsomes from cDNA-Transfected Cells: Effect of Metabolic Inhibitors and SSRI Antidepressants by Fogelman, Steven M, Schmider, Jürgen, Venkatakrishnan, Karthik, von Moltke, Lisa L, Harmatz, Jerold S, Shader, Richard I, Greenblatt, David J

“…The biotransformation of venlafaxine (VF) into its two major metabolites, O-desmethylvenlafaxine (ODV) and N-desmethylvenlafaxine (NDV) was studied in vitro…”
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In Vitro Biotransformation of Sildenafil (Viagra): Identification of Human Cytochromes and Potential Drug Interactions by WARRINGTON, J. S, SHADER, R. I, VON MOLTKE, L. L, GREENBLATT, D. J

“…The in vitro biotransformation of sildenafil to its major circulating metabolite, UK-103,320, was studied in human liver microsomes and in microsomes…”
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Dose-Dependent Pharmacokinetics and Psychomotor Effects of Caffeine in Humans by Kaplan, Gary B., Greenblatt, David J., Ehrenberg, Bruce L., Goddard, Jill E., Cotreau, Monette M., Harmatz, Jerold S., Shader, Richard I.

“…Twelve healthy volunteers received oral placebo, 250 mg of caffeine, and 500 mg of caffeine in a randomized, double‐blind, single‐dose crossover study…”
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Inhibition of alprazolam and desipramine hydroxylation in vitro by paroxetine and fluvoxamine : comparison with other selective serotonin reuptake inhibitor antidepressants by VON MOLTKE, L. L, GREENBLATT, D. J, COURT, M. H, SU XIANG DUAN, HARMATZ, J. S, SHADER, R. I

“…In vitro preparations of human liver microsomes were used to study the inhibiting effects of two selective serotonin reuptake inhibitor (SSRI) antidepressants,…”
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Ritonavir, Efavirenz, and Nelfinavir Inhibit CYP2B6 Activity in Vitro: Potential Drug Interactions with Bupropion by HESSE, Leah M, VON MOLTKE, Lisa L, SHADER, Richard I, GREENBLATT, David J

“…Since antiretroviral drugs are known to inhibit many cytochrome P450 isoforms, the inhibition of CYP2B6 by non-nucleoside reverse transcriptase inhibitors and…”
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Alprazolam-ritonavir interaction: Implications for product labeling by Greenblatt, David J., Moltke, Lisa L., Harmatz, Jerold S., Durol, Anna Liza B., Daily, Johanna P., Graf, Jennifer A., Mertzanis, Polyxane, Hoffman, Jonathan L., Shader, Richard I.

“…Background Pharmacokinetic interactions involving antiretroviral therapies may critically influence the efficacy and toxicity of these drugs, as well as…”
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Inhibitors of alprazolam metabolism in vitro: effect of serotonin‐ reuptake‐inhibitor antidepressants, ketoconazole and quinidine by Moltke, LL, Greenblatt, DJ, Cotreau‐Bibbo, MM, Harmatz, JS, Shader, RI

“…1. The biotransformation of the triazolobenzodiazepine alprazolam (ALP) to its hydroxylated metabolites (4‐OH‐ALP and alpha‐OH‐ALP) was evaluated in human,…”
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Multiple Human Cytochromes Contribute to Biotransformation of Dextromethorphan In-vitro: Role of CYP2C9, CYP2C19, CYP2D6, and CYP3A by Von Moltke, Lisa L., Greenblatt, David J., Grassi, Jeffrey M., Granda, Brian W., Venkatakrishnan, Karthik, Schmider, JÜRgen, Harmatz, Jerold S., Shader, Richard I.

“…Cytochromes mediating the biotransformation of dextromethorphan to dextrorphan and 3‐methoxymorphinan, its principal metabolites in man, have been studied by…”
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N-demethylation of amitriptyline in vitro: role of cytochrome P-450 3A (CYP3A) isoforms and effect of metabolic inhibitors by Schmider, J, Greenblatt, D J, von Moltke, L L, Harmatz, J S, Shader, R I

“…Biotransformation of amitriptyline (AMI) to its demethylated product nortriptyline (NT) was studied in vitro with human liver microsomes from four different…”
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Triazolam biotransformation by human liver microsomes in vitro: effects of metabolic inhibitors and clinical confirmation of a predicted interaction with ketoconazole by von Moltke, L L, Greenblatt, D J, Harmatz, J S, Duan, S X, Harrel, L M, Cotreau-Bibbo, M M, Pritchard, G A, Wright, C E, Shader, R I

“…Biotransformation of the triazolobenzodiazepine triazolam to its hydroxylated metabolites, alpha-hydroxy (OH)- and 4-OH-triazolam, was studied in vitro using…”
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Zolpidem metabolism in vitro: responsible cytochromes, chemical inhibitors, and in vivo correlations by Von Moltke, Lisa L., Greenblatt, David J., Granda, Brian W., Duan, Su Xiang, Grassi, Jeffrey M., Venkatakrishnan, Karthik, Harmatz, Jerold S., Shader, Richard I.

“…Aims To determine the human cytochromes mediating biotransformation of the imidazopyridine hypnotic, zolpidem, and the clinical correlates of the findings…”
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Midazolam hydroxylation by human liver microsomes in vitro: inhibition by fluoxetine, norfluoxetine, and by azole antifungal agents by von Moltke, L L, Greenblatt, D J, Schmider, J, Duan, S X, Wright, C E, Harmatz, J S, Shader, R I

“…Biotransformation of the imidazobenzodiazepine midazolam to its alpha-hydroxy and 4-hydroxy metabolites was studied in vitro using human liver microsomal…”
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Comparative kinetics and dynamics of zaleplon, zolpidem, and placebo by Greenblatt, David J., Harmatz, Jerold S., Moltke, Lisa L., Ehrenberg, Bruce L., Harrel, Lisa, Corbett, Kate, Counihan, Molly, Graf, Jennifer A., Darwish, Mona, Mertzanis, Polyxane, Martin, Patrick T., Cevallos, William H., Shader, Richard I.

“…Purpose This study evaluated the relationship of dose, plasma concentration, and time to the pharmaco‐dynamics of zaleplon and zolpidem, 2 structurally…”
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Five Distinct Human Cytochromes Mediate Amitriptyline N-Demethylation In Vitro: Dominance of CYP 2C19 and 3A4 by Venkatakrishnan, Karthik, Greenblatt, David J., von Moltke, Lisa L., Schmider, Jürgen, Harmatz, Jerold S., Shader, Richard I.

“…The human cytochromes P450 (CYPs) mediating amitriptyline N‐demethylation have been identified using a combination of enzyme kinetic and chemical inhibition…”
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Ketoconazole inhibition of triazolam and alprazolam clearance: Differential kinetic and dynamic consequences by Greenblatt, David J., Wright, C. Eugene, Moltke, Lisa L., Harmatz, Jerold S., Ehrenberg, Bruce L., Harrel, Lisa M., Corbett, Kate, Counihan, Molly, Tobias, Sara, Shader, Richard I.

“…Background Kinetic and dynamic consequences of metabolic inhibition were evaluated in a study of the interaction of ketoconazole, a P4503A inhibitor, with…”
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