Search Results - "Shaddix, Sue C"

Structure-activity relationship for adenosine kinase from Mycobacterium tuberculosis II. Modifications to the ribofuranosyl moiety by LONG, Mary C, SHADDIX, Sue C, MOUKHA-CHAFIQ, Omar, MADDRY, Joseph A, NAGY, Lisa, PARKER, William B

“…Adenosine kinase (Ado kinase) from Mycobacterium tuberculosis is structurally and biochemically unique from other known Ado kinases. This purine salvage enzyme…”
Get full text

Enhancement of the in vivo antitumor activity of clofarabine by 1-β-d-[4-thio-arabinofuranosyl]-cytosine by Parker, William B, Shaddix, Sue C, Gilbert, Karen S, Shepherd, Rodney V, Waud, William R

“…Purpose Clofarabine increases the activation of 1-β-d-arabinofuranosyl cytosine (araC) in tumor cells, and combination of these two drugs has been shown to…”
Get full text

Structure–activity relationship for adenosine kinase from Mycobacterium tuberculosis by Long, Mary C., Shaddix, Sue C., Moukha-Chafiq, Omar, Maddry, Joseph A., Nagy, Lisa, Parker, William B.

“…Adenosine kinase (Ado kinase) from Mycobacterium tuberculosis is structurally and biochemically unique from other known Ado kinases. This purine salvage enzyme…”
Get full text

Metabolism and Metabolic Actions of 6-Methylpurine and 2-Fluoroadenine in Human Cells by Parker, William B, Allan, Paula W, Shaddix, Sue C, Rose, Lucy M, Speegle, Heath F, Gillespie, G.Yancey, Bennett, L.Lee

“…Activation of purine nucleoside analogs by Escherichia coli purine nucleoside phosphorylase (PNP) is being evaluated as a suicide gene therapy strategy for the…”
Get full text

Comparison of the mechanism of cytotoxicity of 2-chloro-9-(2-deoxy-2- fluoro-beta-D-arabinofuranosyl)adenine, 2-chloro-9-(2-deoxy-2-fluoro- beta-D-ribofuranosyl)adenine, and 2-chloro-9-(2-deoxy-2,2-difluoro- beta-D-ribofuranosyl)adenine in CEM cells by Parker, W B, Shaddix, S C, Rose, L M, Shewach, D S, Hertel, L W, Secrist, 3rd, J A, Montgomery, J A, Bennett, Jr, L L

“…In an effort to understand biochemical features that are important to the selective antitumor activity of…”
Get more information

Phosphorylation of 4'-thio-beta-D-arabinofuranosylcytosine and its analogs by human deoxycytidine kinase by Someya, Hitoshi, Shaddix, Sue C, Tiwari, Kamal N, Secrist, 3rd, John A, Parker, William B

“…4'-thio-beta-D-arabinofuranosylcytosine (T-araC) exhibits excellent in vivo antitumor activity against a variety of solid tumors despite its structural…”
Get more information

Enhancement of Nucleoside Cytotoxicity through Nucleotide Prodrugs by Rose, Jerry D, Parker, William B, Someya, Hitoshi, Shaddix, Sue C, Montgomery, John A, Secrist, John A

“…A common reason for the lack of cytotoxicity of certain nucleosides is thought to be their inability to be initially activated to the monophosphate level by a…”
Get full text

Metabolism of 4′-thio-β- d-arabinofuranosylcytosine in CEM cells by Parker, William B, Shaddix, Sue C, Rose, Lucy M, Waud, William R, Shewach, Donna S, Tiwari, Kamal N, Secrist, John A

“…Because of the excellent in vivo activity of 4′-thio-β- d-arabinofuranosylcytosine (T-araC) against a variety of human solid tumors, we have studied its…”
Get full text

Effects of 2-chloro-9-(3-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate by PARKER, W. B, SHADDIX, S. C, CHI-HSIUNG CHANG, WHITE, E. L, ROSE, L. M, BROCKMAN, R. W, SHORTNACY, A. T, MONTGOMERY, J. A, SECRIST, J. A, LEE BENNETT, L. JR

“…2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-adenine (Cl-F-ara-A) has activity against the P388 tumor in mice on several different schedules…”
Get full text

Metabolism of 2-methyladenosine in Mycobacterium tuberculosis by Parker, William B, Barrow, Esther W, Allan, Paula W, Shaddix, Sue C, Long, Mary C, Barrow, William W, Bansal, Namita, Maddry, Joseph A

“…2-Methyladenosine (methyl-Ado) has selective activity against Mycobacterium tuberculosis ( M. tuberculosis). In an effort to better understand its mechanism of…”
Get full text

Metabolism and metabolic actions of 4′-thiothymidine in L1210 cells by Parker, William B., Shaddix, Sue C., Rose, Lucy M., Tiwari, Kamal N., Montgomery, John A., Secrist, John A., Bennett, L.Lee

“…4′-Thiothymidine (S-dThd) is a potent inhibitor of L1210 cell growth and is active against P388 leukemia in mice. Because of these activities and its novel…”
Get full text

Enhancement of the in vivo antitumor activity of clofarabine by 1-[beta]-d-[4-thio-arabinofuranosyl]-cytosine by Parker, William B, Shaddix, Sue C, Gilbert, Karen S, Shepherd, Rodney V, Waud, William R

“…Clofarabine increases the activation of 1-β-d-arabinofuranosyl cytosine (araC) in tumor cells, and combination of these two drugs has been shown to result in…”
Get full text

alpha.-(N)-Formylheteroaromatic thiosemicarbazones. Inhibition of tumor-derived ribonucleoside diphosphate reductase and correlation with in vivo antitumor activity by French, Frederic A, Blanz, Erwin J, Shaddix, Sue C, Brockman, R. Wallace

Get full text

Nitrosoureido nucleosides as potential inhibitors of nucleotide biosynthesis by Elliott, Robert D, Thomas, H. Jeanette, Shaddix, Sue C, Adamson, Doris J, Brockman, R. Wallace, Riordan, James M, Montgomery, John A

“…Several nitrosoureido nucleosides (3a, 3b, 5a, 7a, 7c, and 10a) designed as inhibitors of enzymes that metabolize pyrimidine nucleotides have been prepared and…”
Get full text

Carbocyclic analogs of 5-fluorouracil nucleosides by Shealy, Y. Fulmer, Frye, Jerry L, DuBois, Nancy F, Shaddix, Sue C, Brockman, R. Wallace

“…The carbocyclic analogues of 5-fluoro-2'-deoxyuridine (5-FdUrd, 1), 5-fluorouridine, and 5-fluoro-3 alpha-deoxyuridine were prepared by fluorination of the…”
Get full text

Metabolism and metabolic effects of 2-azahypoxanthine and 2-azaadenosine by Bennett, Jr, L L, Smithers, D, Rose, L M, Adamson, D J, Shaddix, S C, Thomas, H J

“…The metabolism and metabolic effects of 2-azahypoxanthine and 2-azaadenosine were studied to elucidate the biochemical basis for their known cytotoxicities…”
Get more information

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME 4'-C-(HYDROXYMETHYL)-[alpha]- AND -[beta]-D-ARABINOFURANOSYL PYRIMIDINE AND ADENINE NUCLEOSIDES by Griffon, Jean-François, Shaddix, Sue C, Parker, William B, Al-Madhoun, Ashraf S

Get full text

Mechanism of inhibition of human immunodeficiency virus type 1 reverse transcriptase and human DNA polymerases alpha, beta, and gamma by the 5'-triphosphates of carbovir, 3'-azido-3'-deoxythymidine, 2',3'-dideoxyguanosine and 3'-deoxythymidine. A novel RNA template for the evaluation of antiretroviral drugs by W B Parker, E L White, S C Shaddix, L J Ross, R W Buckheit, Jr, J M Germany, J A Secrist, 3rd, R Vince, W M Shannon

“…Carbovir (the carbocyclic analog of 2'-3'-didehydro-2',3'-dideoxyguanosine) is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) replication…”
Get full text

Synthesis and Biological Evaluation of Some 4'-C-(Hydroxymethyl)-α- and -β-D-Arabinofuranosyl Pyrimidine and Adenine Nucleosides by Griffon, Jean-François, Shaddix, Sue C., Parker, William B., Al-Madhoun, Ashraf S., Eriksson, Staffan, Montgomery, John A., Secrist III, John A.

“…A series of 4'- C -(hydroxymethyl) analogs of pyrimidine and purine nucleosides have been prepared utilizing standard methodologies, and the α and β anomers…”
Get full text

Comparison of the effect of Carbovir, AZT, and dideoxynucleoside triphosphates on the activity of human immunodeficiency virus reverse transcriptase and selected human polymerases by White, E L, Parker, W B, Macy, L J, Shaddix, S C, McCaleb, G, Secrist, 3rd, J A, Vince, R, Shannon, W M

“…Carbocylic 2',3'-didehydro-2',3'-dideoxyguanosine (Carbovir; NSC 614846) is an antiretroviral agent which may be useful in the treatment of AIDS. We have…”
Get more information