Search Results - "Shadbad, Mahdi Abdoli"
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Competing endogenous RNA networks and ferroptosis in cancer: novel therapeutic targets
Published in Cell death & disease (22-05-2024)“…As a newly identified regulated cell death, ferroptosis is a metabolically driven process that relies on iron and is associated with polyunsaturated fatty acyl…”
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Immune Checkpoints and CAR-T Cells: The Pioneers in Future Cancer Therapies?
Published in International journal of molecular sciences (05-11-2020)“…Although the ever-increasing number of cancer patients pose substantial challenges worldwide, finding a treatment with the highest response rate and the lowest…”
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PD-L1 silencing inhibits triple-negative breast cancer development and upregulates T-cell-induced pro-inflammatory cytokines
Published in Biomedicine & pharmacotherapy (01-06-2021)“…Triple-negative breast cancer (TNBC) is an invasive tumor with a high incidence of distant metastasis and poor prognosis. In TNBC cells, high PD-L1 expression…”
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4
CircRNA and lncRNA-associated competing endogenous RNA networks in medulloblastoma: a scoping review
Published in Cancer cell international (15-07-2024)“…Medulloblastoma is one of the common primary central nervous system (CNS) malignancies in pediatric patients. The main treatment is surgical resection preceded…”
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HSV1 microRNAs in glioblastoma development: an in silico study
Published in Scientific reports (02-01-2024)“…Glioblastoma multiforme (GBM) is a highly aggressive primary brain tumor. Recent findings highlighted the significance of viral microRNAs (miRs) in regulating…”
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CD133 significance in glioblastoma development: in silico and in vitro study
Published in European journal of medical research (06-03-2024)“…Glioblastoma multiform (GBM) is among the commonly diagnosed brain malignancies with poor prognosis. CD133 has been introduced as an oncogene in various…”
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Regulation of NLRP3 inflammasome by zinc supplementation in Behçet's disease patients: A double-blind, randomized placebo-controlled clinical trial
Published in International immunopharmacology (01-08-2022)“…•Zinc supplementation decreases NLRP3 inflammasome complex expression.•Zinc supplementation alleviates genital ulcer.•Zinc supplementation has no beneficial…”
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Prognostic Role and Clinical Significance of Tumor-Infiltrating Lymphocyte (TIL) and Programmed Death Ligand 1 (PD-L1) Expression in Triple-Negative Breast Cancer (TNBC): A Systematic Review and Meta-Analysis Study
Published in Diagnostics (Basel) (17-09-2020)“…This meta-analysis aimed to evaluate the prognostic value of tumor-infiltrating lymphocytes (TILs) and programmed death-ligand 1 (PD-L1), their associations…”
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Curcumin supplementation contributes to relieving anthropometric and glycemic indices, as an adjunct therapy: A meta-research review of meta-analyses
Published in Journal of functional foods (01-12-2022)“…[Display omitted] •Curcumin supplementation can improve anthropometric and glycemic parameters in a time- and dose- dependent manner.•Administered dose…”
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10
Targeting TGF-β-Mediated SMAD Signaling Pathway via Novel Recombinant Cytotoxin II: A Potent Protein from Naja naja oxiana Venom in Melanoma
Published in Molecules (Basel, Switzerland) (05-11-2020)“…Since the current treatments have not resulted in the desired outcomes for melanoma patients, there is a need to identify more effective medications. Together…”
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B7 immune checkpoint family members as putative therapeutics in autoimmune disease: An updated overview
Published in International journal of rheumatic diseases (01-03-2022)“…Autoimmune diseases, especially among young people in the US, are one of the leading causes of morbidity and death. The immune responses are the fundamental…”
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12
Tumor-infiltrating CD8+ sub-populations in primary and recurrent glioblastoma: An in-silico study
Published in Heliyon (15-03-2024)“…Glioblastoma multiforme (GBM) remains an incurable primary brain tumor. CD8+ tumor-infiltrating lymphocytes (TILs) can target malignant cells; however, their…”
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13
The expression pattern of VISTA in the PBMCs of relapsing-remitting multiple sclerosis patients: A single-cell RNA sequencing-based study
Published in Biomedicine & pharmacotherapy (01-04-2022)“…Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS). Dysregulated immune responses have been implicated in MS development…”
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A Systematic Review to Clarify the Prognostic Values of CD44 and CD44+CD24- Phenotype in Triple-Negative Breast Cancer Patients: Lessons Learned and The Road Ahead
Published in Frontiers in oncology (09-08-2021)“…As a unique population of tumor bulk, cancer stem cells have been implicated in tumor relapse and chemoresistance in triple-negative breast cancer (TNBC)…”
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15
MiR-146a Restoration Suppresses Triple-Negative Breast Cancer Cell Migration: A Bioinformatic and in Vitro Study
Published in Advanced pharmaceutical bulletin (01-08-2022)“…Purpose: Breast cancer is one of the most commonly diagnosed types of cancer worldwide. This cancer is treated with various methods like mastectomy,…”
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EZH2 knockdown upregulates expression of the genes involved in T-ALL cell differentiation
Published in Pharmaceutical Sciences (01-07-2022)“…Background: EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit), as one of the polycyclic group proteins (PcGs), is an epigenetic regulator that…”
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Cross-talk between myeloid-derived suppressor cells and Mucin1 in breast cancer vaccination: On the verge of a breakthrough
Published in Life sciences (1973) (01-10-2020)“…Although breast cancer is one of the leading troublesome cancers, the available therapeutic options have not fulfilled the desired outcomes. Immune-based…”
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The role of CD44 in cancer chemoresistance: A concise review
Published in European journal of pharmacology (15-07-2021)“…CD44 is a cell surface adhesion molecule, which is overexpressed on cancer stem cells. The interaction of CD44 with hyaluronan is responsible for tumor…”
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Interleukin-1 in obesity-related low-grade inflammation: From molecular mechanisms to therapeutic strategies
Published in International immunopharmacology (01-07-2021)“…•IL-1 is known a master cytokine because of its involvement in local and systemic inflammation.•Overexpression of IL-1 in adipose tissues leads to infiltrating…”
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hsa-miR-34a-5p enhances temozolomide anti-tumoral effects on glioblastoma: in-silico and in-vitro study
Published in EXCLI journal (01-01-2024)“…Glioblastoma multiform (GBM) is a commonly diagnosed brain neoplasm with a poor prognosis. Accumulating evidence has highlighted the significance of microRNA…”
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