Search Results - "Shackleford, Terry J."

JAB1/CSN5: a new player in cell cycle control and cancer by Shackleford, Terry J, Claret, Francois X

“…c-Jun activation domain-binding protein-1 (Jab1) acts as a modulator of intracellular signaling and affects cellular proliferation and apoptosis, through its…”
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Stat3 and CCAAT/enhancer binding protein beta (C/EBP-beta) regulate Jab1/CSN5 expression in mammary carcinoma cells by Shackleford, Terry J, Zhang, Qingxiu, Tian, Ling, Vu, Thuy T, Korapati, Anita L, Baumgartner, Angela M, Le, Xiao-Feng, Liao, Warren S, Claret, Francois X

“…The c-Jun coactivator, Jun activation-domain binding protein 1 (Jab1) also known as the fifth component of the COP9 signalosome complex (CSN5), is a novel…”
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Redundant Signaling as the Predominant Mechanism for Resistance to Antibodies Targeting the Type-I Insulin-Like Growth Factor Receptor in Cells Derived from Childhood Sarcoma by Shackleford, Terry J, Hariharan, Seethalakshmi, Vaseva, Angelina V, Alagoa, Karina, Espinoza, Maricruz, Bid, Hemant K, Li, Fuyang, Zhong, Haihong, Phelps, Doris A, Roberts, Ryan D, Cam, Hakan, London, Cheryl A, Guttridge, Denis C, Chen, Yidong, Rao, Manjeet, Shiio, Yuzuru, Houghton, Peter J

“…Antibodies targeting insulin-like growth factor 1 receptor (IGF-1R) induce objective responses in only 5% to 15% of children with sarcoma. Understanding the…”
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Vertical Inhibition of the RAF-MEK-ERK Cascade Induces Myogenic Differentiation, Apoptosis, and Tumor Regression in H/NRAS Q61X Mutant Rhabdomyosarcoma by Garcia, Natalia, Del Pozo, Vanessa, Yohe, Marielle E, Goodwin, Craig M, Shackleford, Terry J, Wang, Long, Baxi, Kunal, Chen, Yidong, Rogojina, Anna T, Zimmerman, Sara M, Peer, Cody J, Figg, William D, Ignatius, Myron S, Wood, Kris C, Houghton, Peter J, Vaseva, Angelina V

“…Oncogenic RAS signaling is an attractive target for fusion-negative rhabdomyosarcoma (FN-RMS). Our study validates the role of the ERK MAPK effector pathway in…”
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Vertical Inhibition of the RAF–MEK–ERK Cascade Induces Myogenic Differentiation, Apoptosis, and Tumor Regression in H/NRASQ61X Mutant Rhabdomyosarcoma by Garcia, Natalia, Del Pozo, Vanessa, Yohe, Marielle E., Goodwin, Craig M., Shackleford, Terry J., Wang, Long, Baxi, Kunal, Chen, Yidong, Rogojina, Anna T., Zimmerman, Sara M., Peer, Cody J., Figg, William D., Ignatius, Myron S., Wood, Kris C., Houghton, Peter J., Vaseva, Angelina V.

“…Abstract Oncogenic RAS signaling is an attractive target for fusion-negative rhabdomyosarcoma (FN-RMS). Our study validates the role of the ERK MAPK effector…”
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Effect of low-fat diets on plasma levels of NF-κB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer by Heymach, John V, Shackleford, Terry J, Tran, Hai T, Yoo, Suk-Young, Do, Kim-Anh, Wergin, Melanie, Saintigny, Pierre, Vollmer, Robin T, Polascik, Thomas J, Snyder, Denise C, Ruffin, 4th, Mack T, Yan, Shaoyu, Dewhirst, Mark, Kunnumakkara, Ajaikumar B, Aggarwal, Bharat B, Demark-Wahnefried, Wendy

“…Diet, nutritional status, and certain dietary supplements are postulated to influence the development and progression of prostate cancer. Angiogenesis and…”
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Abstract 5825: Mechanisms of intrinsic and acquired resistance to antibodies targeting IGF-1R in pediatric sarcoma cell lines by Shackleford, Terry J., Hariharan, Seethalakshmi, Phelps, Doris, Bid, Hemant, Zhong, Hiahong, Houghton, Peter

“…Abstract Background: Pediatric bone and soft tissue sarcomas are heavily dependent on the Type 1 insulin-like growth factor receptor (IGF-1R) signaling axis,…”
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Abstract 2472: Mechanisms of resistance to IGFR-targeted therapy in pediatric sarcomas by Shackleford, Terry J., Hariharan, Seethalakshmi, Bid, Hemant K., Houghton, Peter J.

“…Abstract Background: Insulin-like growth factor-I receptor (IGFR) signaling promotes tumorigenic properties which makes targeting IGFR an attractive…”
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Abstract 1825: Jab1/Csn5 a new target in the resistant mechanism to HER2-targeted therapies for breast cancer by Claret, Francois X., Vu, Thuy, Shackleford, Terry J., Allensworth, Jennifer, Zhang, Qingxiu, Tian, Ling, Zhang, Ronghua

“…Abstract Her2 positive (Her2+) breast cancer (BC) accounts for 20% of all breast cancer subtypes and is associated with high risk of death. Trastuzumab (Ttzm),…”
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Abemaciclib is Active in Preclinical Models of Ewing's Sarcoma via Multi-pronged Regulation of Cell Cycle, DNA Methylation, and Interferon Pathway Signaling by Dowless, Michele S, Lowery, Caitlin D, Shackleford, Terry J, Renschler, Matthew, Stephens, Jennifer R, Flack, Robert, Blosser, Wayne, Gupta, Simone, Stewart, Julie, Webster, Yue, Dempsey, Jack, VanWye, Alle B, Ebert, Philip J, Iversen, Philip, Olsen, Jonathan B, Gong, Xueqian, Buchanan, Sean G, Houghton, Peter J, Stancato, Louis F

“…Ewing's sarcoma (ES) is a rare and highly malignant cancer that occurs in the bone and surrounding tissue of children and adolescents. The EWS/ETS fusion…”
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Abstract B231: Jab1/Csn5 a new player driving the resistance to Her2-targeted therapies for breast cancer by Vu, Thuy T., Shackleford, Terry J., Zhang, Qingxiu, Esteva, Francisco J., Drakos, Elias, Tian, Ling, Kute, Timothy, Sahin, Aysegul A., Rassidakis, George Z., Claret, Francois X.

“…Abstract Her2 a key member in the epidermal growth factor receptor (EGFR) family, is one of the most dominant oncogenes in breast cancer. It is overexpressed…”
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Abstract PR-09: Low-fat diet reduces NF-κB regulated inflammatory cytokines and angiogenic factors in plasma of men with prostate cancer by Heymach, John V., Shackleford, Terry J., Tran, Hai T., Yoo, Suk-Young, Do, Kim-Anh, Wergin, Melanie, Saintigny, Pierre, Vollmer, Robin T., Polascik, Thomas J., Snyder, Denise C., Ruffin, Mack T., Yan, Shaoyu, Dewhirst, Mark, Kunnamakara, Ajai B., Aggarwal, Bharat B., Demark-Wahnefried, Wendy

“…Abstract Purpose: Diet and certain dietary supplements are postulated to influence the development and progression of prostate cancer. Angiogenesis and…”
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