Search Results - "Shackleford, David M."

Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage by Francisco, Amanda Fortes, Jayawardhana, Shiromani, Lewis, Michael D., White, Karen L., Shackleford, David M., Chen, Gong, Saunders, Jessica, Osuna-Cabello, Maria, Read, Kevin D., Charman, Susan A., Chatelain, Eric, Kelly, John M.

“…The insect-transmitted protozoan parasite Trypanosoma cruzi is the causative agent of Chagas disease, and infects 5–8 million people in Latin America. Chagas…”
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An in vitro toolbox to accelerate anti-malarial drug discovery and development by Charman, Susan A, Andreu, Alice, Barker, Helena, Blundell, Scott, Campbell, Anna, Campbell, Michael, Chen, Gong, Chiu, Francis C K, Crighton, Elly, Katneni, Kasiram, Morizzi, Julia, Patil, Rahul, Pham, Thao, Ryan, Eileen, Saunders, Jessica, Shackleford, David M, White, Karen L, Almond, Lisa, Dickins, Maurice, Smith, Dennis A, Moehrle, Joerg J, Burrows, Jeremy N, Abla, Nada

“…Modelling and simulation are being increasingly utilized to support the discovery and development of new anti-malarial drugs. These approaches require reliable…”
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Discovery and Structure–Activity Relationships of Quinazolinone-2-carboxamide Derivatives as Novel Orally Efficacious Antimalarials by Laleu, Benoît, Akao, Yuichiro, Ochida, Atsuko, Duffy, Sandra, Lucantoni, Leonardo, Shackleford, David M, Chen, Gong, Katneni, Kasiram, Chiu, Francis C. K, White, Karen L, Chen, Xue, Sturm, Angelika, Dechering, Koen J, Crespo, Benigno, Sanz, Laura M, Wang, Binglin, Wittlin, Sergio, Charman, Susan A, Avery, Vicky M, Cho, Nobuo, Kamaura, Masahiro

“…A phenotypic high-throughput screen allowed discovery of quinazolinone-2-carboxamide derivatives as a novel antimalarial scaffold. Structure–activity…”
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Enhancing the Oral Absorption of Kinase Inhibitors Using Lipophilic Salts and Lipid-Based Formulations by Williams, Hywel D., Ford, Leigh, Han, Sifei, Tangso, Kristian J., Lim, Shea, Shackleford, David M., Vodak, David T., Benameur, Hassan, Pouton, Colin W., Scammells, Peter J., Porter, Christopher J. H.

“…The absolute bioavailability of many small molecule kinase inhibitors (smKIs) is low. The reasons for low bioavailability are multifaceted and include…”
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Structure–Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439) by Dong, Yuxiang, Wang, Xiaofang, Kamaraj, Sriraghavan, Bulbule, Vivek J, Chiu, Francis C. K, Chollet, Jacques, Dhanasekaran, Manickam, Hein, Christopher D, Papastogiannidis, Petros, Morizzi, Julia, Shackleford, David M, Barker, Helena, Ryan, Eileen, Scheurer, Christian, Tang, Yuanqing, Zhao, Qingjie, Zhou, Lin, White, Karen L, Urwyler, Heinrich, Charman, William N, Matile, Hugues, Wittlin, Sergio, Charman, Susan A, Vennerstrom, Jonathan L

“…Building on insights gained from the discovery of the antimalarial ozonide arterolane (OZ277), we now describe the structure–activity relationship (SAR) of the…”
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Discovery and Structure–Activity Relationships of Pyrrolone Antimalarials by Murugesan, Dinakaran, Mital, Alka, Kaiser, Marcel, Shackleford, David M, Morizzi, Julia, Katneni, Kasiram, Campbell, Michael, Hudson, Alan, Charman, Susan A, Yeates, Clive, Gilbert, Ian H

“…In the pursuit of new antimalarial leads, a phenotypic screening of various commercially sourced compound libraries was undertaken by the World Health…”
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3,5-Diaryl-2-aminopyridines as a Novel Class of Orally Active Antimalarials Demonstrating Single Dose Cure in Mice and Clinical Candidate Potential by Younis, Yassir, Douelle, Frederic, Feng, Tzu-Shean, Cabrera, Diego González, Manach, Claire Le, Nchinda, Aloysius T, Duffy, Sandra, White, Karen L, Shackleford, David M, Morizzi, Julia, Mannila, Janne, Katneni, Kasiram, Bhamidipati, Ravi, Zabiulla, K. Mohammed, Joseph, Jayan T, Bashyam, Sridevi, Waterson, David, Witty, Michael J, Hardick, David, Wittlin, Sergio, Avery, Vicky, Charman, Susan A, Chibale, Kelly

“…A novel class of orally active antimalarial 3,5-diaryl-2-aminopyridines has been identified from phenotypic whole cell high-throughput screening of a…”
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Selecting an anti-malarial clinical candidate from two potent dihydroisoquinolones by Chen, Yizhe, Zhu, Fangyi, Hammill, Jared, Holbrook, Gloria, Yang, Lei, Freeman, Burgess, White, Karen L, Shackleford, David M, O'Loughlin, Kathleen G, Charman, Susan A, Mirsalis, Jon C, Guy, R Kiplin

“…The ongoing global malaria eradication campaign requires development of potent, safe, and cost-effective drugs lacking cross-resistance with existing…”
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The Anti-Inflammatory Drug Aspirin Does Not Protect Against Chemotherapy-Induced Memory Impairment by Paclitaxel in Mice by Chang, Aeson, Chung, Ni-Chun, Lawther, Adam J, Ziegler, Alexandra I, Shackleford, David M, Sloan, Erica K, Walker, Adam K

“…Inflammation has been proposed to play a causal role in chemobrain which-if true-would represent an opportunity to repurpose existing anti-inflammatory drugs…”
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Antimalarial Activity of Pyrroloiminoquinones from the Australian Marine Sponge Zyzzya sp by Davis, Rohan A, Buchanan, Malcolm S, Duffy, Sandra, Avery, Vicky M, Charman, Susan A, Charman, William N, White, Karen L, Shackleford, David M, Edstein, Michael D, Andrews, Katherine T, Camp, David, Quinn, Ronald J

“…A new bispyrroloiminoquinone alkaloid, tsitsikammamine C (1), displayed potent in vitro antimalarial activity with IC50 values of 13 and 18 nM against…”
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Antitrypanosomal Activity of Fexinidazole Metabolites, Potential New Drug Candidates for Chagas Disease by BAHIA, Maria T, NASCIMENTO, Alvaro F. S, KOLTUN, Maria, SAUNDERS, Jessica, WHITE, Karen L, SCANDALE, Ivan, CHARMAN, Susan A, CHATELAIN, Eric, MAZZETI, Ana Lia, MARQUES, Luiz F, GONCALVES, Karolina R, MOTA, Ludmilla W. R, DINIZ, Lívia de F, CALDAS, Ivo S, TALVANI, André, SHACKLEFORD, David M

“…This study was designed to verify the in vivo efficacy of sulfoxide and sulfone fexinidazole metabolites following oral administration in a murine model of…”
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Increased In Vivo Exposure of N-(4-Hydroxyphenyl) Retinamide (4-HPR) to Achieve Plasma Concentrations Effective against Dengue Virus by Martin, Alexander J, Shackleford, David M, Charman, Susan A, Wagstaff, Kylie M, Porter, Christopher J H, Jans, David A

“…N-(4-hydroxyphenyl) retinamide (4-HPR, or fenretinide) has promising in vitro and in vivo antiviral activity against a range of flaviviruses and an established…”
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The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease by Finkelstein, David I, Billings, Jessica L, Adlard, Paul A, Ayton, Scott, Sedjahtera, Amelia, Masters, Colin L, Wilkins, Simon, Shackleford, David M, Charman, Susan A, Bal, Wojciech, Zawisza, Izabela A, Kurowska, Ewa, Gundlach, Andrew L, Ma, Sheri, Bush, Ashley I, Hare, Dominic J, Doble, Philip A, Crawford, Simon, Gautier, Elisabeth Cl, Parsons, Jack, Huggins, Penny, Barnham, Kevin J, Cherny, Robert A

“…Elevated iron in the SNpc may play a key role in Parkinson's disease (PD) neurodegeneration since drug candidates with high iron affinity rescue PD animal…”
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Progress in antischistosomal N,N′-diaryl urea SAR by Wu, Jianbo, Wang, Chunkai, Leas, Derek, Vargas, Mireille, White, Karen L., Shackleford, David M., Chen, Gong, Sanford, Austin G., Hemsley, Ryan M., Davis, Paul H., Dong, Yuxiang, Charman, Susan A., Keiser, Jennifer, Vennerstrom, Jonathan L.

“…[Display omitted] •Expansion of antischistosomal N,N′-diaryl urea SAR.•3-Trifluoromethyl-4-pyridyl and 2,2-difluorobenzodioxole improve…”
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Pharmacological Characterization, Structural Studies, and In Vivo Activities of Anti-Chagas Disease Lead Compounds Derived from Tipifarnib by BUCKNER, Frederick S, TEREZINHA BAHIA, Maria, VERLINDE, Christophe L. M. J, CHARMAN, Susan A, LEPESHEVA, Galina I, GELBC, Michael H, KUMAR SURYADEVARA, Praveen, WHITE, Karen L, SHACKLEFORD, David M, KUMAR CHENNAMANENI, Naveen, HULVERSON, Matthew A, LAYDBAK, Joy U, CHATELAIN, Eric, SCANDALE, Ivan

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Synthesis and Biological Evaluation of Polysulfated Oligosaccharide Glycosides as Inhibitors of Angiogenesis and Tumor Growth by Johnstone, Ken D, Karoli, Tomislav, Liu, Ligong, Dredge, Keith, Copeman, Elizabeth, Li, Cai Ping, Davis, Kat, Hammond, Edward, Bytheway, Ian, Kostewicz, Edmund, Chiu, Francis C. K, Shackleford, David M, Charman, Susan A, Charman, William N, Harenberg, Job, Gonda, Thomas J, Ferro, Vito

“…A series of polysulfated penta- and tetrasaccharide glycosides containing α(1→3)/α(1→2)-linked mannose residues were synthesized as heparan sulfate (HS)…”
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PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective by Orozco Morales, M. Lizeth, Rinaldi, Catherine A., de Jong, Emma, Lansley, Sally M., Gummer, Joel P.A., Olasz, Bence, Nambiar, Shabarinath, Hope, Danika E., Casey, Thomas H., Lee, Y. C. Gary, Leslie, Connull, Nealon, Gareth, Shackleford, David M., Powell, Andrew K., Grimaldi, Marina, Balaguer, Patrick, Zemek, Rachael M., Bosco, Anthony, Piggott, Matthew J., Vrielink, Alice, Lake, Richard A., Lesterhuis, W. Joost

“…Mesothelioma is a cancer that typically originates in the pleura of the lungs. It rapidly invades the surrounding tissues, causing pain and shortness of…”
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Correction to: The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease by Finkelstein, David I, Billings, Jessica L, Adlard, Paul A, Ayton, Scott, Sedjahtera, Amelia, Masters, Colin L, Wilkins, Simon, Shackleford, David M, Charman, Susan A, Bal, Wojciech, Zawisza, Izabela A, Kurowska, Ewa, Gundlach, Andrew L, Ma, Sheri, Bush, Ashley I, Hare, Dominic J, Doble, Philip A, Crawford, Simon, Gautier, Elisabeth C. L, Parsons, Jack, Huggins, Penny, Barnham, Kevin J, Cherny, Robert A

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Preoperative β-Blockade with Propranolol Reduces Biomarkers of Metastasis in Breast Cancer: A Phase II Randomized Trial by Hiller, Jonathan G, Cole, Steven W, Crone, Elizabeth M, Byrne, David J, Shackleford, David M, Pang, Jia-Min B, Henderson, Michael A, Nightingale, Sophie S, Ho, Kwok M, Myles, Paul S, Fox, Stephen, Riedel, Bernhard, Sloan, Erica K

“…The majority of deaths from breast cancer occur following the development of metastatic disease, a process inhibited by β-blockers in preclinical studies. This…”
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Contribution of lymphatically transported testosterone undecanoate to the systemic exposure of testosterone after oral administration of two andriol formulations in conscious lymph duct-cannulated dogs by Shackleford, David M, Faassen, W A, Houwing, Natalie, Lass, Holger, Edwards, Glenn A, Porter, Christopher J H, Charman, William N

“…Orally administered testosterone (T) is ineffective in the treatment of male androgen deficiency syndromes due to extensive presystemic first-pass metabolism…”
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