Search Results - "Shackelford, Deborah"

DNA end joining activity is reduced in Alzheimer's disease by Shackelford, Deborah A.

“…Evidence indicates that oxidative stress-induced damage to DNA, protein, and other cellular components contributes to the progression of Alzheimer's disease…”
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Epitope Specific Antibodies and T Cell Receptors in the Immune Epitope Database by Mahajan, Swapnil, Vita, Randi, Shackelford, Deborah, Lane, Jerome, Schulten, Veronique, Zarebski, Laura, Jespersen, Martin Closter, Marcatili, Paolo, Nielsen, Morten, Sette, Alessandro, Peters, Bjoern

“…The Immune Epitope Database (IEDB) is a free public resource which catalogs experiments characterizing immune epitopes. To accommodate data from next…”
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Modulation of ERK and JNK activity by transient forebrain ischemia in rats by Shackelford, Deborah A., Yeh, Richard Y.

“…The mitogen‐activated protein (MAP) kinase families of ERK and JNK participate in numerous intracellular signaling pathways and are abundantly expressed in the…”
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Is DNA repair compromised in Alzheimer’s disease? by Davydov, Vladislav, Hansen, Lawrence A., Shackelford, Deborah A.

“…Mammalian cells utilize multiple mechanisms to repair DNA damage that occurs during normal cellular respiration and in response to genotoxic stress. This study…”
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Changes in Expression of the DNA Repair Protein Complex DNA-Dependent Protein Kinase after Ischemia and Reperfusion by Shackelford, Deborah A, Tobaru, Takaaki, Zhang, Shengjia, Zivin, Justin A

“…Reperfusion of ischemic tissue causes an immediate increase in DNA damage, including base lesions and strand breaks. Damage is reversible in surviving regions…”
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IEDB‐3D 2.0: Structural data analysis within the Immune Epitope Database by Mendes, Marcus, Mahita, Jarjapu, Blazeska, Nina, Greenbaum, Jason, Ha, Brendan, Wheeler, Kelly, Wang, Jiyao, Shackelford, Deborah, Sette, Alessandro, Peters, Bjoern

“…The Immune Epitope Database (IEDB) catalogs T cell, B cell, and major histocompatibility complex ligand information in the context of infectious disease,…”
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IEDB-3D 2.0: Enabling visualization of epitopes on the 3D structure of the corresponding antigens by De Almeida Mendes, Marcus F, Mahita, Jarjapu, Blazeska, Nina, Wheeler, Daniel, Ha, Brendan, Greenbaum, Jason, Wang, Jiyao, Shackelford, Deborah, Sette, Alessandro, Peters, Bjoern

“…Abstract The Immune Epitope Database and Analysis Resource (IEDB) contains information related to antibodies, T cells, and MHC across a broad spectrum of…”
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Differences in a dinucleotide repeat polymorphism in the tau gene between Caucasian and Japanese populations: implication for progressive supranuclear palsy by Conrad, Chris, Amano, Naoji, Andreadis, Athena, Xia, Yu, Namekataf, Kazuhiko, Oyama, Fumitaka, Ikeda, Kenji, Wakabayashi, Koichi, Takahashi, Hitoshi, J. Thal, Leon, Katzman, Robert, Shackelford, Deborah A, Matsushita, Masaaki, Masliah, Eliezer, Sawa, Akira

“…Previous studies of a tau polymorphism in Caucasian subjects with progressive supranuclear palsy (PSP) showed an over-representation of one genotype, A0/A0,…”
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The Immune Epitope Database (IEDB): 2024 update by Vita, Randi, Blazeska, Nina, Marrama, Daniel, Shackelford, Deborah, Zalman, Leora, Foos, Gabriele, Zarebski, Laura, Chan, Kenneth, Reardon, Brian, Fitzpatrick, Sidne, Busse, Matthew, Coleman, Sara, Sedwick, Caitlin, Edwards, Lindy, MacFarlane, Catriona, Ennis, Marcus, Duesing, Sebastian, Bennett, Jason, Greenbaum, Jason, De Almeida Mendes, Marcus, Mahita, Jarjapu, Wheeler, Daniel K, Cantrell, Jason R, Overton, James A, Natale, Darren A, Sette, Alessandro, Peters, Bjoern

“…Abstract Over the past 20 years, the Immune Epitope Database (IEDB, iedb.org) has established itself as the foremost resource for immune epitope data. The IEDB…”
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A behind‐the‐scenes tour of the IEDB curation process: an optimized process empirically integrating automation and human curation efforts by Salimi, Nima, Edwards, Lindy, Foos, Gabriele, Greenbaum, Jason A., Martini, Sheridan, Reardon, Brian, Shackelford, Deborah, Vita, Randi, Zalman, Leora, Peters, Bjoern, Sette, Alessandro

“…The Immune Epitope Database and Analysis Resource (IEDB) provides the scientific community with open access to epitope data, as well as epitope prediction and…”
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Activation of extracellular signal-regulated kinases (ERK) during reperfusion of ischemic spinal cord by Shackelford, Deborah A., Yeh, Richard Y.

“…The extracellular signal-regulated kinases (ERK) participate in numerous signaling pathways and are abundantly expressed in the CNS. It has been proposed that…”
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Differential effects of ischemia and reperfusion on c-Jun N-terminal kinase isoform protein and activity by Shackelford, Deborah A, Yeh, Richard Y

“…Activation of the c-Jun N-terminal (JNK) or stress-activated protein kinases (SAPK) is associated with a wide range of disparate cellular responses to…”
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Activation of nuclear factor-κB in the rabbit spinal cord following ischemia and reperfusion by Zhang, Shengjia, Tobaru, Takaaki, Zivin, Justin A, Shackelford, Deborah A

“…The transcription factor NF-κB is a ubiquitously expressed inducible regulator of a broad range of genes. Recent studies have shown that activation of NF-κB…”
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Dephosphorylation of tau during transient forebrain ischemia in the rat by Shackelford, D A, Yeh, R Y

“…The effect of transient cerebral ischemia on phosphorylation of the microtubule-associated protein (MAP) tau was investigated using the rat four-vessel…”
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Human B-Cell Alloantigens DC1, MT1, and LB12 are Identical to Each Other but Distinct from the HLA-DR Antigen by Shackelford, Deborah A., Mann, Dean L., VanRood, Jon J., Ferrara, G. B., Strominger, Jack L.

“…Some human B-lymphoblastoid cell lines are shown to express at least two types of Ia-like antigens. One antigen is defined by alloantisera to HLA-DR, and the…”
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Expression of CD45 Alters Phosphorylation of the lck-Encoded Tyrosine Protein Kinase in Murine Lymphoma T-Cell Lines by Ostergaard, Hanne L., Shackelford, Deborah A., Hurley, Tamara R., Johnson, Pauline, Hyman, Robert, Sefton, Bartholomew M., Trowbridge, Ian S.

“…CD45 is a family of high molecular weight leukocyte cell surface glycoproteins. Recently, two related subregions of the cytoplasmic domain of CD45 have been…”
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Rapid Fragmentation of Vimentin in Human Skin Fibroblasts Exposed to Tamoxifen: A Possible Involvement of Caspase-3 by Hashimoto, Makoto, Inoue, Satoshi, Ogawa, Sumito, Conrad, Chris, Muramatsu, Masami, Shackelford, Deborah, Masliah, Eliezer

“…Tamoxifen (TAM), an anti-estrogen compound, is widely used for chemotherapy of breast cancer, although the molecular mechanisms underlying TAM cytotoxicity are…”
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The class II molecules of the human and murine major histocompatibility complex by Kaufman, J F, Auffray, C, Korman, A J, Shackelford, D A, Strominger, J

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Changes in phosphorylation of tau during ischemia and reperfusion in the rabbit spinal cord by Shackelford, D A, Nelson, K E

“…The microtubule-associated protein tau plays an important role in the dynamics of microtubule assembly necessary for axonal growth and neurite plasticity…”
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Diffuse subcutaneous emphysema, pneumomediastinum, and pneumothorax after dental extraction by Shackelford, D, Casani, J A

“…Subcutaneous emphysema, pneumomediastinum, and pneumothorax may result from surgical procedures and trauma and usually do not present a diagnostic dilemma. We…”
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