Search Results - "Shackel, N. A"

Diabetes and Nonalcoholic Fatty Liver Disease: A Pathogenic Duo by Williams, K. H, Shackel, N. A, Gorrell, M. D, McLennan, S. V, Twigg, S. M

“…Recent data increasingly support a complex interplay between the metabolic condition diabetes mellitus and the pathologically defined nonalcoholic fatty liver…”
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Monocyte CD147 is induced by advanced glycation end products and high glucose concentration: possible role in diabetic complications by Bao, W, Min, D, Twigg, S M, Shackel, N A, Warner, F J, Yue, D K, McLennan, S V

“…CD147 is a highly glycosylated transmembrane protein that is known to play a role in regulation of many protein families. It has the unique ability to maintain…”
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Identification of novel molecules and pathogenic pathways in primary biliary cirrhosis: cDNA array analysis of intrahepatic differential gene expression by Shackel, N A, McGuinness, P H, Abbott, C A, Gorrell, M D, McCaughan, G W

“…BACKGROUND Primary biliary cirrhosis (PBC) is an autoimmune disease in which the pathogenesis of progressive liver injury is poorly understood. AIM To provide…”
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Assessment of adult patients with chronic liver failure for liver transplantation in 2015: who and when? by McCaughan, G. W., Crawford, M., Sandroussi, C., Koorey, D. J., Bowen, D. G., Shackel, N. A., Strasser, S. I.

“…In 2015, there are a few absolute contraindications to liver transplantation. In adult patients, survival post‐liver transplant is excellent, with 1‐year…”
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Discussion on differential gene expression between chronic hepatitis B and C hepatic lesion by McCaughan, G.W., Shackel, N.A., Gorrell, M.D.

“…GASTROENTEROLOGY 2001;121:1263-1264…”
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Clonal expansion of hepatocytes with a selective advantage occurs during all stages of chronic hepatitis B virus infection by Tu, T., Mason, W. S., Clouston, A. D., Shackel, N. A., McCaughan, G. W., Yeh, M. M., Schiff, E. R., Ruszkiewicz, A. R., Chen, J. W., Harley, H. A. J., Stroeher, U. H., Jilbert, A. R.

“…Summary Hepatocyte clone size was measured in liver samples of 21 patients in various stages of chronic hepatitis B virus (HBV) infection and from 21 to…”
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Virus Genotype-Dependent Transcriptional Alterations in Lipid Metabolism and Inflammation Pathways in the Hepatitis C Virus-infected Liver by d’Avigdor, W. M. H., Budzinska, M. A., Lee, M., Lam, R., Kench, J., Stapelberg, M., McLennan, S. V., Farrell, G., George, J., McCaughan, G. W., Tu, T., Shackel, N. A.

“…Despite advances in antiviral therapy, molecular drivers of Hepatitis C Virus (HCV)-related liver disease remain poorly characterised. Chronic infection with…”
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Increasing liver transplantation waiting list mortality: a report from the Australian National Liver Transplantation Unit, Sydney by Prakoso, E., Verran, D., Dilworth, P., Kyd, G., Tang, P., Tse, C., Koorey, D. J., Strasser, S. I., Stormon, M., Shun, A., Thomas, G., Joseph, D., Pleass, H., Gallagher, J., Allen, R., Crawford, M., McCaughan, G. W., Shackel, N. A.

“…Background:  We aimed to describe the demand for liver transplantation (LTx) and patient outcomes on the waiting list at the Australian National Liver…”
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Liver biopsy: is it still relevant? by Shackel, N. A., McCaughan, G. W.

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Lower serum fibroblast activation protein shows promise in the exclusion of clinically significant liver fibrosis due to non-alcoholic fatty liver disease in diabetes and obesity by Williams, K.H, Viera de Ribeiro, A.J, Prakoso, E, Veillard, A.S, Shackel, N.A, Bu, Y, Brooks, B, Cavanagh, E, Raleigh, J, McLennan, S.V, McCaughan, G.W, Bachovchin, W.W, Keane, F.M, Zekry, A, Twigg, S.M, Gorrell, M.D

“…Highlights • Many patients with diabetes/obesity and NAFLD have significant liver fibrosis. • Circulating biomarkers to exclude liver fibrosis in NAFLD are…”
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Longitudinal assessment of hepatitis C fibrosis progression by collagen and smooth muscle actin morphometry in comparison to serum markers by Patel, K., Tillmann, H. L., Matta, B., Sheridan, M. J., Gardner, S. D., Shackel, N. A., McHutchison, J. G., Goodman, Z. D.

“…Summary Background Assessment of fibrosis progression in chronic liver disease relies upon non‐invasive tools and changes in semi‐quantitative histopathology…”
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Terlipressin therapy for moderate-to-severe hyponatraemia in patients with liver failure by Prakoso, E., Jones, C., Koorey, D. J., Strasser, S. I., Bowen, D., McCaughan, G. W., Shackel, N. A.

“…Background Hyponatraemia in liver failure is associated with increased morbidity and mortality. Improving serum sodium in liver failure has been observed in…”
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Copper‐salicylate gel for pain relief in osteoarthritis: a randomised controlled trial by Shackel, Nicholas A, Day, Richard O, Kellett, Bruce, Brooks, Peter M

“…ObjectiveTo assess the efficacy and safety of a copper‐salicylate gel in osteoarthritis of the hip and knee. DesignRandomised, double‐blind, placebo‐controlled…”
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Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) for measurement of cytokine and growth factor mRNA expression with fluorogenic probes or SYBR Green I by Yin, Jian Lin, Shackel, Nicholas A, Zekry, Amany, McGuinness, Peter H, Richards, Craig, Van Der Putten, Karien, McCaughan, Geoffrey W, Eris, Josette M, Bishop, G Alex

“…Real‐time quantitative reverse transcriptase–polymerase chain reaction (RT–PCR) is the method of choice for rapid and reproducible measurements of cytokine or…”
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Video push enteroscopy in the investigation of small bowel disease: defining clinical indications and outcomes by Shackel, N. A., Bowen, D. G., Selby, W. S.

“…Background: Push enteroscopy is a new technique for investigation of the small intestine. The clinical indications are still being defined. It also offers the…”
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Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance by McCaughan, Geoffrey W., Gorrell, Mark D., Bishop, G. Alex, Abbott, Catherine A., Shackel, Nicholas A., McGuinness, Peter H., Levy, Miriam T., Sharland, Alexandra F., Bowen, David G., Yu, Denise, Slaitini, Loubnah, Church, W. Bret, Napoli, John

“…The hallmarks of chronic liver diseases are chronic inflammation, cellular damage, regeneration and fibrosis. An appreciation of intrahepatic molecular…”
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East meets West: Acute liver failure in the global village by Bowen, David G, Shackel, Nicholas A, Mccaughan, Geoffrey W

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Author reply by Prakoso, E., Jones, C., Koorey, D. J., Strasser, S. I., Bowen, D., McCaughan, G. W., Shackel, N. A.

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Author reply by Prakoso, E., Jones, C., Koorey, D. J., Strasser, S. I., Bowen, D., McCaughan, G. W., Shackel, N. A.

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Author reply by Prakoso, E., Jones, C., Koorey, D. J., Strasser, S. I., Bowen, D., McCaughan, G. W., Shackel, N. A.

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