Search Results - "Shabaneh, Tamer B."

Molecular basis of differential sensitivity of myeloma cells to clinically relevant bolus treatment with bortezomib by Shabaneh, Tamer B, Downey, Sondra L, Goddard, Ayrton L, Screen, Michael, Lucas, Marcella M, Eastman, Alan, Kisselev, Alexei F

“…The proteasome inhibitor bortezomib (Velcade) is prescribed for the treatment of multiple myeloma. Clinically achievable concentrations of bortezomib cause…”
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The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells by Kraus, Marianne, Bader, Juergen, Geurink, Paul P, Weyburne, Emily S, Mirabella, Anne C, Silzle, Tobias, Shabaneh, Tamer B, van der Linden, Wouter A, de Bruin, Gerjan, Haile, Sarah R, van Rooden, Eva, Appenzeller, Christina, Li, Nan, Kisselev, Alexei F, Overkleeft, Herman, Driessen, Christoph

“…Proteasome inhibitor resistance is a challenge for myeloma therapy. Bortezomib targets the β5 and β1 activity, but not the β2 activity of the proteasome…”
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Resident memory CD8+ T cells in regional lymph nodes mediate immunity to metastatic melanoma by Molodtsov, Aleksey K., Khatwani, Nikhil, Vella, Jennifer L., Lewis, Kathryn A., Zhao, Yanding, Han, Jichang, Sullivan, Delaney E., Searles, Tyler G., Preiss, Nicholas K., Shabaneh, Tamer B., Zhang, Peisheng, Hawkes, Aaron R., Malik, Brian T., Kolling, Fred W., Usherwood, Edward J., Wong, Sandra L., Phillips, Joseph D., Shirai, Keisuke, Angeles, Christina V., Yan, Shaofeng, Curiel, Tyler J., Huang, Yina H., Cheng, Chao, Turk, Mary Jo

“…The nature of the anti-tumor immune response changes as primary tumors progress and metastasize. We investigated the role of resident memory (Trm) and…”
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Myeloid Cells That Impair Immunotherapy Are Restored in Melanomas with Acquired Resistance to BRAF Inhibitors by Steinberg, Shannon M, Shabaneh, Tamer B, Zhang, Peisheng, Martyanov, Viktor, Li, Zhenghui, Malik, Brian T, Wood, Tamara A, Boni, Andrea, Molodtsov, Aleksey, Angeles, Christina V, Curiel, Tyler J, Whitfield, Michael L, Turk, Mary Jo

“…Acquired resistance to BRAF inhibitors (BRAFi) in melanoma remains a common clinical obstacle, as is the case for any targeted drug therapy that can be…”
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Immune evasion of dormant disseminated tumor cells is due to their scarcity and can be overcome by T cell immunotherapies by Goddard, Erica T, Linde, Miles H, Srivastava, Shivani, Klug, Grant, Shabaneh, Tamer B, Iannone, Santino, Grzelak, Candice A, Marsh, Sydney, Riggio, Alessandra I, Shor, Ryann E, Linde, Ian L, Guerrero, Marissa, Veatch, Joshua R, Snyder, Annelise G, Welm, Alana L, Riddell, Stanley R, Ghajar, Cyrus M

“…The period between "successful" treatment of localized breast cancer and the onset of distant metastasis can last many years, representing an unexploited…”
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Microbiota dictate T cell clonal selection to augment graft-versus-host disease after stem cell transplantation by Yeh, Albert C, Koyama, Motoko, Waltner, Olivia G, Minnie, Simone A, Boiko, Julie R, Shabaneh, Tamer B, Takahashi, Shuichiro, Zhang, Ping, Ensbey, Kathleen S, Schmidt, Christine R, Legg, Samuel R W, Sekiguchi, Tomoko, Nelson, Ethan, Bhise, Shruti S, Stevens, Andrew R, Goodpaster, Tracy, Chakka, Saranya, Furlan, Scott N, Markey, Kate A, Bleakley, Marie E, Elson, Charles O, Bradley, Philip H, Hill, Geoffrey R

“…Allogeneic T cell expansion is the primary determinant of graft-versus-host disease (GVHD), and current dogma dictates that this is driven by…”
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Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks by Jaeger-Ruckstuhl, Carla A, Lo, Yun, Fulton, Elena, Waltner, Olivia G, Shabaneh, Tamer B, Simon, Sylvain, Muthuraman, Pranav V, Correnti, Colin E, Newsom, Oliver J, Engstrom, Ian A, Kanaan, Sami B, Bhise, Shruti S, Peralta, Jobelle M C, Ruff, Raymond, Price, Jason P, Stull, Sylvia M, Stevens, Andrew R, Bugos, Grace, Kluesner, Mitchell G, Voillet, Valentin, Muhunthan, Vishaka, Morrish, Fionnuala, Olson, James M, Gottardo, Raphaël, Sarthy, Jay F, Henikoff, Steven, Sullivan, Lucas B, Furlan, Scott N, Riddell, Stanley R

“…The interaction of the tumor necrosis factor receptor (TNFR) family member CD27 on naive CD8 T (Tn) cells with homotrimeric CD70 on antigen-presenting cells…”
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An epoxide hydrolase secreted by Pseudomonas aeruginosa decreases mucociliary transport and hinders bacterial clearance from the lung by Hvorecny, Kelli L, Dolben, Emily, Moreau-Marquis, Sophie, Hampton, Thomas H, Shabaneh, Tamer B, Flitter, Becca A, Bahl, Christopher D, Bomberger, Jennifer M, Levy, Bruce D, Stanton, Bruce A, Hogan, Deborah A, Madden, Dean R

“…The opportunistic pathogen Pseudomonas aeruginosa colonizes the lungs of susceptible individuals by deploying virulence factors targeting host defenses. The…”
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Acidosis potentiates the host proinflammatory interleukin-1β response to Pseudomonas aeruginosa infection by Torres, Iviana M, Patankar, Yash R, Shabaneh, Tamer B, Dolben, Emily, Hogan, Deborah A, Leib, David A, Berwin, Brent L

“…Infection by Pseudomonas aeruginosa, and bacteria in general, frequently promotes acidification of the local microenvironment, and this is reinforced by…”
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Oncogenic BRAFV600E Governs Regulatory T-cell Recruitment during Melanoma Tumorigenesis by Shabaneh, Tamer B., Molodtsov, Aleksey K., Steinberg, Shannon M., Zhang, Peisheng, Torres, Gretel M., Mohamed, Gadisti A., Boni, Andrea, Curiel, Tyler J., Angeles, Christina V., Turk, Mary Jo

“…Abstract Regulatory T cells (Treg) are critical mediators of immunosuppression in established tumors, although little is known about their role in restraining…”
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BRAF inhibition alleviates immune suppression in murine autochthonous melanoma by Steinberg, Shannon M, Zhang, Peisheng, Malik, Brian T, Boni, Andrea, Shabaneh, Tamer B, Byrne, Katelyn T, Mullins, David W, Brinckerhoff, Constance E, Ernstoff, Marc S, Bosenberg, Marcus W, Turk, Mary Jo

“…A growing body of evidence suggests that BRAF inhibitors, in addition to their acute tumor growth-inhibitory effects, can also promote immune responses to…”
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Safety switch optimization enhances antibody-mediated elimination of CAR T cells by Shabaneh, Tamer B, Moffett, Howell F, Stull, Sylvia M, Derezes, Thomas, Tait, Leah J, Park, Spencer, Riddell, Stan R, Lajoie, Marc J

“…Activation of a conditional safety switch has the potential to reverse serious toxicities arising from the administration of engineered cellular therapies,…”
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Specific Cell-Permeable Inhibitor of Proteasome Trypsin-like Sites Selectively Sensitizes Myeloma Cells to Bortezomib and Carfilzomib by Mirabella, Anne C., Pletnev, Alexandre A., Downey, Sondra L., Florea, Bogdan I., Shabaneh, Tamer B., Britton, Matthew, Verdoes, Martijn, Filippov, Dmitri V., Overkleeft, Herman S., Kisselev, Alexei F.

“…Proteasomes degrade the majority of proteins in mammalian cells, are involved in the regulation of multiple physiological functions, and are established…”
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Discovery of a potent and highly β1 specific proteasome inhibitor from a focused library of urea-containing peptide vinyl sulfones and peptide epoxyketones by van der Linden, Wouter A, Willems, Lianne I, Shabaneh, Tamer B, Li, Nan, Ruben, Mark, Florea, Bogdan I, van der Marel, Gijs A, Kaiser, Markus, Kisselev, Alexei F, Overkleeft, Herman S

“…Syringolins, a class of natural products, potently and selectively inhibit the proteasome and show promising antitumour activity. To gain insight in the mode…”
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Microbiota-Specific T Cells Contribute to Graft-Versus-Host Disease after Allogeneic Stem Cell Transplantation by Yeh, Albert C, Koyama, Motoko, Waltner, Olivia, Minnie, Simone A, Boiko, Julie, Shabaneh, Tamer B, Takahashi, Shuichiro, Zhang, Ping, Ensbey, Kathleen, Schmidt, Christine, Legg, Samuel, Sekiguchi, Tomoko, Nelson, Ethan, Bhise, Shruti, Stevens, Andrew, Goodpaster, Tracy A, Chakka, Saranya R., Furlan, Scott N., Markey, Kate A., Bleakley, Marie, Elson, Charles O, Hill, Geoffrey R

“…Background: Allogeneic T-cell expansion is the primary determinant of graft-versus-host disease (GVHD), and current dogma dictates that this is driven by…”
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Myeloid cells that impair immunotherapy are restored in melanomas which acquire resistance to BRAF inhibitors by Steinberg, Shannon M., Shabaneh, Tamer B., Zhang, Peisheng, Martyanov, Viktor, Li, Zhenghui, Malik, Brian T., Wood, Tamara A., Boni, Andrea, Molodtsov, Aleksey, Angeles, Christina V., Curiel, Tyler J., Whitfield, Michael L., Turk, Mary Jo

“…Acquired resistance to BRAF V600E inhibitors (BRAFi) in melanoma remains a common clinical obstacle, as is the case for any targeted drug therapy that can be…”
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Oncogenic BRAF V600E Governs Regulatory T-cell Recruitment during Melanoma Tumorigenesis by Shabaneh, Tamer B, Molodtsov, Aleksey K, Steinberg, Shannon M, Zhang, Peisheng, Torres, Gretel M, Mohamed, Gadisti A, Boni, Andrea, Curiel, Tyler J, Angeles, Christina V, Turk, Mary Jo

“…Regulatory T cells (Treg) are critical mediators of immunosuppression in established tumors, although little is known about their role in restraining…”
Get full text