Search Results - "Sha, Jihui"
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1
Arabidopsis MORC proteins function in the efficient establishment of RNA directed DNA methylation
Published in Nature communications (13-07-2021)“…The Microrchidia (MORC) family of ATPases are required for transposable element (TE) silencing and heterochromatin condensation in plants and animals, and C…”
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2
Role of cytoneme structures and extracellular vesicles in Trichomonas vaginalis parasite-parasite communication
Published in eLife (02-05-2023)“…the etiologic agent of the most common non-viral sexually transmitted infection worldwide. With an estimated annual prevalence of 276 million new cases, mixed…”
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3
BCC0 collaborates with IMC32 and IMC43 to form the Toxoplasma gondii essential daughter bud assembly complex
Published in PLoS pathogens (01-07-2024)“…Toxoplasma gondii divides by endodyogeny, in which two daughter buds are formed within the cytoplasm of the maternal cell using the inner membrane complex…”
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4
Systematic characterization of all Toxoplasma gondii TBC domain-containing proteins identifies an essential regulator of Rab2 in the secretory pathway
Published in PLoS biology (07-05-2024)“…Toxoplasma gondii resides in its intracellular niche by employing a series of specialized secretory organelles that play roles in invasion, host cell…”
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5
VPS32, a member of the ESCRT complex, modulates adherence to host cells in the parasite Trichomonas vaginalis by affecting biogenesis and cargo sorting of released extracellular vesicles
Published in Cellular and molecular life sciences : CMLS (01-01-2022)“…Trichomonas vaginalis is a common sexually transmitted extracellular parasite that adheres to epithelial cells in the human urogenital tract. Extracellular…”
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Identification of IMC43, a novel IMC protein that collaborates with IMC32 to form an essential daughter bud assembly complex in Toxoplasma gondii
Published in PLoS pathogens (01-10-2023)“…The inner membrane complex (IMC) of Toxoplasma gondii is essential for all phases of the parasite's life cycle. One of its most critical roles is to act as a…”
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7
A synthetic coolant (WS-23) in disposable electronic cigarettes impairs cytoskeletal function in EpiAirway microtissues exposed at the air liquid interface
Published in Scientific reports (07-10-2023)“…The design of popular disposable electronic cigarettes (ECs) was analyzed, and the concentrations of WS-23, a synthetic coolant, in EC fluids were determined…”
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8
PEXEL is a proteolytic maturation site for both exported and non-exported Plasmodium proteins
Published in mSphere (28-02-2024)“…Obligate intracellular malaria parasites dramatically remodel their erythrocyte host through effector protein export to create a niche for survival. Most…”
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9
FAP106 is an interaction hub for assembling microtubule inner proteins at the cilium inner junction
Published in Nature communications (26-08-2023)“…Motility of pathogenic protozoa depends on flagella (synonymous with cilia) with axonemes containing nine doublet microtubules (DMTs) and two singlet…”
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10
Chemical Derivatization of Affinity Matrices Provides Protection from Tryptic Proteolysis
Published in Journal of proteome research (04-10-2019)“…The enrichment of biotinylated proteins using immobilized streptavidin has become a staple methodology for affinity purification-based proteomics. Many of…”
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IMC29 Plays an Important Role in Toxoplasma Endodyogeny and Reveals New Components of the Daughter-Enriched IMC Proteome
Published in mBio (28-02-2023)“…The inner membrane complex (IMC) is a unique organelle that plays critical roles in parasite motility, invasion, egress, and replication. The IMC is delineated…”
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12
A Novel Toxoplasma Inner Membrane Complex Suture-Associated Protein Regulates Suture Protein Targeting and Colocalizes with Membrane Trafficking Machinery
Published in mBio (26-10-2021)“…The cytoskeleton of Toxoplasma gondii is composed of the inner membrane complex (IMC) and an array of underlying microtubules that provide support at the…”
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13
The Toxoplasma gondii effector GRA83 modulates the host's innate immune response to regulate parasite infection
Published in mSphere (24-10-2023)“…'s propensity to infect its host and cause disease is highly dependent on its ability to modulate host cell functions. One of the strategies the parasite uses…”
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14
A genetic model for in vivo proximity labelling of the mammalian secretome
Published in Open biology (10-08-2022)“…Organ functions are highly specialized and interdependent. Secreted factors regulate organ development and mediate homeostasis through serum trafficking and…”
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15
Nicotine Affects Multiple Biological Processes in EpiDermTM Organotypic Tissues and Keratinocyte Monolayers
Published in Atmosphere (16-05-2022)“…Dermal exposure to nicotine is common due to the widespread use of tobacco products. Here, we assessed the effects of nicotine at concentrations found in…”
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16
Wild-type C-Raf gene dosage and dimerization drive prostate cancer metastasis
Published in iScience (15-12-2023)“…Mutated Ras and Raf kinases are well-known to promote cancer metastasis via flux through the Ras/Raf/MEK/ERK (mitogen-activated protein kinase [MAPK]) pathway…”
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MOTS-c modulates skeletal muscle function by directly binding and activating CK2
Published in iScience (01-11-2024)“…MOTS-c is a mitochondrial microprotein that improves metabolism. Here, we demonstrate CK2 is a direct and functional target of MOTS-c. MOTS-c directly binds to…”
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18
High-Field Asymmetric Waveform Ion Mobility Spectrometry Interface Enhances Parallel Reaction Monitoring on an Orbitrap Mass Spectrometer
Published in Analytical chemistry (Washington) (22-11-2022)“…High-field asymmetric waveform ion mobility spectrometry (FAIMS) enables gas-phase separations on a chromatographic time scale and has become a useful tool for…”
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Carboxylate-Modified Magnetic Bead (CMMB)-Based Isopropanol Gradient Peptide Fractionation (CIF) Enables Rapid and Robust Off-Line Peptide Mixture Fractionation in Bottom-Up Proteomics
Published in Molecular & cellular proteomics (01-01-2021)“…Deep proteome coverage in bottom-up proteomics requires peptide-level fractionation to simplify the complex peptide mixture before analysis by tandem mass…”
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20
Human Multisubunit E3 Ubiquitin Ligase Required for Heterotrimeric G‑Protein β‑Subunit Ubiquitination and Downstream Signaling
Published in Journal of proteome research (03-09-2021)“…G-protein-coupled receptors (GPCRs) initiate intracellular signaling events through heterotrimeric G-protein α-subunits (Gα) and the βγ-subunit dimer (Gβγ). In…”
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