Search Results - "Shúilleabháin, Deirdre Ní"

Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies by Townsend, Sue, Fennell, Brian J., Apgar, James R., Lambert, Matthew, McDonnell, Barry, Grant, Joanne, Wade, Jason, Franklin, Edward, Foy, Niall, Shúilleabháin, Deirdre Ní, Fields, Conor, Darmanin-Sheehan, Alfredo, King, Amy, Paulsen, Janet E., Hickling, Timothy P., Tchistiakova, Lioudmila, Cunningham, Orla, Finlay, William J. J.

“…Although humanized antibodies have been highly successful in the clinic, all current humanization techniques have potential limitations, such as: reliance on…”
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Class I Rab11-family interacting proteins are binding targets for the Rab14 GTPase by Kelly, Eoin E., Horgan, Conor P., Adams, Christine, Patzer, Tomasz M., Shúilleabháin, Deirdre M. Ní, Norman, Jim C., McCaffrey, Mary W.

“…Background information. Rab11 and Rab14 are two related Rab GTPases that are believed to function in endosomal recycling and Golgi/endosome transport…”
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CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery by Fennell, Brian J, McDonnell, Barry, Tam, Amy Sze Pui, Chang, Lijun, Steven, John, Broadbent, Ian D, Gao, Huilan, Kieras, Elizabeth, Alley, Jennifer, Luxenberg, Deborah, Edmonds, Jason, Fitz, Lori J, Miao, Wenyan, Whitters, Matthew J, Medley, Quintus G, Guo, Yongjing J, Darmanin-Sheehan, Alfredo, Autin, Bénédicte, Shúilleabháin, Deirdre Ní, Cummins, Emma, King, Amy, Krebs, Mark RH, Grace, Christopher, Hickling, Timothy P, Boisvert, Angela, Zhong, Xiaotian, McKenna, Matthew, Francis, Christopher, Olland, Stephane, Bloom, Laird, Paulsen, Janet, Somers, Will, Jensen, Allan, Lin, Laura, Finlay, William JJ, Cunningham, Orla

“…While myriad molecular formats for bispecific antibodies have been examined to date, the simplest structures are often based on the scFv. Issues with stability…”
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Fundamental characteristics of the immunoglobulin VH repertoire of chickens in comparison with those of humans, mice, and camelids by Wu, Leeying, Oficjalska, Katarzyna, Lambert, Matthew, Fennell, Brian J, Darmanin-Sheehan, Alfredo, Ní Shúilleabháin, Deirdre, Autin, Bénédicte, Cummins, Emma, Tchistiakova, Lioudmila, Bloom, Laird, Paulsen, Janet, Gill, Davinder, Cunningham, Orla, Finlay, William J J

“…Examination of 1269 unique naive chicken V(H) sequences showed that the majority of positions in the framework (FW) regions were maintained as germline, with…”
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An Ultra-specific Avian Antibody to Phosphorylated Tau Protein Reveals a Unique Mechanism for Phosphoepitope Recognition by Shih, Heather H., Tu, Chao, Cao, Wei, Klein, Anne, Ramsey, Renee, Fennell, Brian J., Lambert, Matthew, Ní Shúilleabháin, Deirdre, Autin, Bénédicte, Kouranova, Eugenia, Laxmanan, Sri, Braithwaite, Steven, Wu, Leeying, Ait-Zahra, Mostafa, Milici, Anthony J., Dumin, Jo Ann, LaVallie, Edward R., Arai, Maya, Corcoran, Christopher, Paulsen, Janet E., Gill, Davinder, Cunningham, Orla, Bard, Joel, Mosyak, Lydia, Finlay, William J.J.

“…Highly specific antibodies to phosphoepitopes are valuable tools to study phosphorylation in disease states, but their discovery is largely empirical, and the…”
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Phage Display: A Powerful Technology for the Generation of High-Specificity Affinity Reagents from Alternative Immune Sources by Finlay, William J J, Bloom, Laird, Grant, Joanne, Franklin, Edward, Shúilleabháin, Deirdre Ní, Cunningham, Orla

“…Antibodies are critical reagents in many fundamental biochemical methods such as affinity chromatography, enzyme-linked immunosorbent assays (ELISA), flow…”
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