Search Results - "Sguigna, Peter V"

Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8 by Jo, Youngah, Lee, Peter C. W, Sguigna, Peter V, DeBose-Boyd, Russell A

“…Accumulation of sterols in membranes of the endoplasmic reticulum (ER) leads to the accelerated ubiquitination and proteasomal degradation of…”
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Membrane-associated Ubiquitin Ligase Complex Containing gp78 Mediates Sterol-accelerated Degradation of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase by Jo, Youngah, Sguigna, Peter V., DeBose-Boyd, Russell A.

“…The endoplasmic reticulum (ER)-associated degradation (ERAD) pathway in the yeast Saccharomyces cerevisiae is mediated by two membrane-bound ubiquitin ligases,…”
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Evidence of brain target engagement in Parkinson's disease and multiple sclerosis by the investigational nanomedicine, CNM-Au8, in the REPAIR phase 2 clinical trials by Ren, Jimin, Rynders, Austin, Evan, Jacob, Evan, Jeremy, Ligozio, Shelia, Ho, Karen S, Sguigna, Peter V, Glanzman, Robert, Hotchkin, Michael T, Dewey, Jr, Richard B, Greenberg, Benjamin M

“…Impaired brain energy metabolism has been observed in many neurodegenerative diseases, including Parkinson's disease (PD) and multiple sclerosis (MS). In both…”
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Correction: Evidence of brain target engagement in Parkinson's disease and multiple sclerosis by the investigational nanomedicine, CNM- Au8, in the REPAIR phase 2 clinical trials by Ren, Jimin, Dewey, 3rd, Richard B, Rynders, Austin, Evan, Jacob, Evan, Jeremy, Ligozio, Shelia, Ho, Karen S, Sguigna, Peter V, Glanzman, Robert, Hotchkin, Michael T, Dewey, Jr, Richard B, Greenberg, Benjamin M

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A narrative review of neuro-ophthalmologic disease in African Americans and Hispanics with multiple sclerosis by Tardo, Lauren, Salter, Amber, Truong-Le, Melanie, Horton, Lindsay, Blackburn, Kyle M., Sguigna, Peter V.

“…Multiple sclerosis (MS) is the most common non-traumatic cause of disability in young people, with vision loss in the disease representing the second largest…”
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Cladribine tablets after treatment with natalizumab (CLADRINA) - rationale and design by Sguigna, Peter V, Hussain, Rehana Z, Okai, Annette, Blackburn, Kyle M, Tardo, Lauren, Madinawala, Mariam, Korich, Julie, Lebson, Lori A, Kaplan, Jeffrey, Salter, Amber, Manouchehri, Navid, Stuve, Olaf

“…Individual disease modifying therapies approved for multiple sclerosis (MS) have limited effectiveness and potentially serious side effects, especially when…”
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Design and Implementation of a Brief, Self-Directed Course on Immunotherapy Best Practices for Neurology Trainees by Blackburn, Kyle M, Sguigna, Peter V, Tardo, Lauren, Khan, Shaida, Vernino, Steven, Phillips, Lauren

“…To create and implement a brief, self-directed course on immunotherapy (IT) best practices for trainees on a neuroimmunology elective rotation. A working group…”
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A cross‐sectional natural history study of aspartylglucosaminuria by Goodspeed, Kimberly, Horton, Daniel, Lowden, Andrea, Sguigna, Peter V., Booth, Timothy, Wang, Zhiyue J., Edgar, Veronica Bordes

“…Aspartylglucosaminuria (AGU) is a rare lysosomal storage disorder that causes stagnation of development in adolescence and neurodegeneration in early…”
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The sequential natalizumab – alemtuzumab therapy in patients with relapsing forms of multiple sclerosis (SUPPRESS) trial – Part I: Rationale and objectives by Hussain, Rehana Z, Sguigna, Peter V, Okai, Annette, Wright, Crystal, Madinawala, Mariam, Bass, Ann D, Cutter, Gary R, Manouchehri, Navid, Stuve, Olaf

“…Background Natalizumab is a recombinant humanized monoclonal antibody (mAb) against α4-integrin that is approved for relapsing forms of multiple sclerosis…”
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Asymptomatic retinal vasculopathy in neuropsychiatric systemic lupus erythematosus by Sguigna, Peter V., Tardo, Lauren, Conger, Darrel, Hogan, Robert, Greenberg, Benjamin M.

“…•NPSLE is a heterogeneous disorder without a robust diagnostic test.•There is increasing evidence that a vasculopathy mediates NPSLE pathophysiology.•Optical…”
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Subclinical optic neuritis in pediatric myelin oligodendrocyte glycoprotein antibody-associated disease by Nguyen, Linda, Wang, Cynthia X., Conger, Darrel L., Sguigna, Peter V., Singh, Sumit, Greenberg, Benjamin M.

“…•16% of children with MOGAD had subclinical optic neuritis based on RNFL changes.•Asymptomatic significant elevation in RNFL can be seen with MOGAD.•OCT should…”
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Retinal Architecture and Melanopsin-Mediated Pupillary Response Characteristics: A Putative Pathophysiologic Signature for the Retino-Hypothalamic Tract in Multiple Sclerosis by Meltzer, Ethan, Sguigna, Peter V, Subei, Adnan, Beh, Shin, Kildebeck, Eric, Conger, Darrel, Conger, Amy, Lucero, Marlen, Frohman, Benjamin S, Frohman, Ashley N, Saidha, Shiv, Galetta, Steven, Calabresi, Peter A, Rennaker, Robert, Frohman, Teresa C, Kardon, Randy H, Balcer, Laura J, Frohman, Elliot M

“…A neurophysiologic signature of the melanopsin-mediated persistent constriction phase of the pupillary light reflex may represent a surrogate biomarker for the…”
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Generative artificial intelligence versus clinicians: Who diagnoses multiple sclerosis faster and with greater accuracy? by Patel, Mahi A., Villalobos, Francisco, Shan, Kevin, Tardo, Lauren M., Horton, Lindsay A., Sguigna, Peter V., Blackburn, Kyle M., Munoz, Shanan B., Moog, Tatum M., Smith, Alexander D., Burgess, Katy W., McCreary, Morgan, Okuda, Darin T.

“…•Generative AI is increasingly used as a tool for patient education by Generation Z.•ChatGPT is able to diagnose patients with MS faster than their real-life…”
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Utilization of Visual Acuity Retroilluminated Charts for the Assessment of Afferent Visual System Dysfunction in a Pediatric Neuroimmunology Population by Sguigna, Peter V., McCreary, Morgan C., Conger, Darrel L., Graves, Jennifer S., Benson, Leslie A., Waldman, Amy T., Greenberg, Benjamin M.

“…BACKGROUND:Visual acuity has been a significant outcome measure in clinical trials for patients suffering from neuro-ophthalmological diseases and multiple…”
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Application of the International Interocular Difference Thresholds into Practice: Localising the Patient Experience by Sguigna, Peter V., Tardo, Lauren M., Blackburn, Kyle M., Horton, Lindsay A., Conger, Darrel L., Hogan, R. Nick, McCreary, Morgan C., Greenberg, Benjamin M.

“…Demyelinating diseases of the central nervous system (CNS) often have neuro-ophthalmological manifestations, and retinal examination can be helpful in making…”
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Disease associations of excessive daytime sleepiness in multiple sclerosis: A prospective study by Sguigna, Peter V, Toranian, Sabeen, Tardo, Lauren M, Blackburn, Kyle M, Horton, Lindsay A, Conger, Darrel, Meltzer, Ethan, Hogan, R Nick, McCreary, Morgan C, Zee, Phyllis C, Takahashi, Joseph S, Greenberg, Benjamin M

“…Background Excessive daytime sleepiness (EDS) in multiple sclerosis (MS) can be a significant source of disability. Despite this, its prevalence as a…”
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Bringing continuous target-tracking to the clinic: Steps toward developing new tools for assessing visual dysfunction by Shields, Stephanie M., Toranian, Sabeen, Sguigna, Peter V., Meltzer, Ethan, Cormack, Lawrence K.

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