Search Results - "Sgroi, Mariana"
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A decision process for drug discovery in retinoblastoma
Published in Investigational new drugs (01-04-2021)“…Summary Intraocular retinoblastoma treatment has changed radically over the last decade, leading to a notable improvement in ocular survival. However, eyes…”
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Tridimensional Retinoblastoma Cultures as Vitreous Seeds Models for Live-Cell Imaging of Chemotherapy Penetration
Published in International journal of molecular sciences (02-03-2019)“…A preclinical model could aid in understanding retinoblastoma vitreous seeds behavior, drug penetration, and response to chemotherapy to optimize patient…”
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Topotecan Delivery to the Optic Nerve after Ophthalmic Artery Chemosurgery
Published in PloS one (09-03-2016)“…Extraocular retinoblastoma is a major challenge worldwide, especially in developing countries. Current treatment involves the administration of systemic…”
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Ocular findings in children with acute leukemia at a tertiary care center in South America
Published in Oman journal of ophthalmology (01-05-2022)“…PURPOSE: The purpose of this study was to evaluate ophthalmological findings in patients with acute myeloid leukemia (AML) and acute lymphoblastic leukemia…”
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Tractional retinal detachment and juxtapapillary retinal capillary hemangioma in a 6-year-old girl: A case report
Published in Oman journal of ophthalmology (01-01-2022)“…A 6-year-old girl with visual impairment in the right eye (OD) was referred for an eye evaluation. The fundus of the OD showed a fibrotic orange endophytic…”
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Subsequent malignant neoplasms in the pediatric age in retinoblastoma survivors in Argentina
Published in Pediatric blood & cancer (01-08-2022)“…Background Retinoblastoma survivors in low‐ and middle‐income countries are exposed to high‐intensity treatments that potentially place them at higher risk of…”
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Use of iodine-125 episcleral brachytherapy treatment for circumscribed choroidal hemangioma in a pediatric patient
Published in Taiwan journal of ophthalmology (19-07-2024)“…Abstract The purpose of this report is to highlight the results of iodine-125 episcleral plaque radiotherapy for the treatment of circumscribed choroidal…”
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Establishment and Comprehensive Characterization of a Novel Preclinical Platform of Metastatic Retinoblastoma for Therapeutic Developments
Published in Investigative ophthalmology & visual science (01-12-2023)“…Although there have been improvements in the management of metastatic retinoblastoma, most patients do not survive, and all patients suffer from multiple…”
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Combined high‐dose intra‐arterial and intrathecal chemotherapy for the treatment of a case of extraocular retinoblastoma
Published in Pediatric blood & cancer (01-12-2018)“…Patients with retinoblastoma and central nervous system (CNS) involvement are rarely curable with available treatments. We designed a high‐dose intra‐arterial…”
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Genomic and Transcriptomic Tumor Heterogeneity in Bilateral Retinoblastoma
Published in JAMA ophthalmology (01-05-2020)“…Comprehensive understanding of the genomic and gene-expression differences between retinoblastoma tumors from patients with bilateral disease may help to…”
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Feasibility and results of an intraarterial chemotherapy program for the conservative treatment of retinoblastoma in Argentina
Published in Pediatric blood & cancer (01-08-2018)“…Background The feasibility and results of intraarterial chemotherapy, also termed ophthalmic artery chemosurgery (OAC), for retinoblastoma in less developed…”
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Retinoblastoma Outcomes in the Americas: A Prospective Analysis of 491 Children With Retinoblastoma From 23 American Countries
Published in American journal of ophthalmology (01-04-2024)“…Globally, disparities exist in retinoblastoma treatment outcomes between high- and low-income countries, but independent analysis of American countries is…”
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Clinical, Genomic, and Pharmacological Study of MYCN-Amplified RB1 Wild-Type Metastatic Retinoblastoma
Published in Cancers (22-09-2020)“…An uncommon subgroup of unilateral retinoblastomas with highly aggressive histological features, lacking aberrations in RB1 gene with high-level amplification…”
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Ocular topotecan pharmacokinetics following topical administration to rabbits for diffused anterior retinoblastoma
Published in Journal of pharmacy and pharmacology (01-05-2017)“…Objectives We characterized and compared the in‐vivo absorption of topotecan into the aqueous humor after instillation of aqueous and ointment formulations…”
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Pharmacokinetics, Safety, and Efficacy of Intravitreal Digoxin in Preclinical Models for Retinoblastoma
Published in Investigative ophthalmology & visual science (01-07-2015)“…To assess in vitro cytotoxic activity and antiangiogenic effect, ocular and systemic disposition, and toxicity of digoxin in rabbits after intravitreal…”
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Topotecan Delivery to the Optic Nerve after Ophthalmic Artery Chemosurgery: e0151343
Published in PloS one (01-03-2016)“…Extraocular retinoblastoma is a major challenge worldwide, especially in developing countries. Current treatment involves the administration of systemic…”
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