Search Results - "Sgraja, Tanja"

An Essential Role for Aspartate 264 in Catalysis by tRNA-Guanine Transglycosylase from Escherichia coli by Kittendorf, Jeffrey D., Sgraja, Tanja, Reuter, Klaus, Klebe, Gerhard, Garcia, George A.

“…tRNA-guanine transglycosylase (TGT) catalyzes a post-transcriptional base-exchange reaction involved in the incorporation of the modified base queuine (Q) into…”
Get full text

Characterization of Aquifex aeolicus 4-diphosphocytidyl-2C-methyl- d-erythritol kinase - ligand recognition in a template for antimicrobial drug discovery by Sgraja, Tanja, Alphey, Magnus S, Ghilagaber, Stephanos, Marquez, Rudi, Robertson, Murray N, Hemmings, Jennifer L, Lauw, Susan, Rohdich, Felix, Bacher, Adelbert, Eisenreich, Wolfgang, Illarionova, Victoria, Hunter, William N

“…4-Diphosphocytidyl-2C-methyl- d-erythritol kinase (IspE) catalyses the ATP-dependent conversion of 4-diphosphocytidyl-2C-methyl- d-erythritol (CDPME) to…”
Get full text

Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase by Sgraja, Tanja, Smith, Terry K, Hunter, William N

“…Isoprenoid precursor synthesis via the mevalonate route in humans and pathogenic trypanosomatids is an important metabolic pathway. There is however, only…”
Get full text

Crystal structure of Bacillus subtilis S-adenosylmethionine:tRNA ribosyltransferase-isomerase by Grimm, Clemens, Ficner, Ralf, Sgraja, Tanja, Haebel, Peter, Klebe, Gerhard, Reuter, Klaus

“…The enzyme S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) is involved in the biosynthesis of the hypermodified tRNA nucleoside queuosine. It is…”
Get full text

Synthesis and Characterization of Cytidine Derivatives that Inhibit the Kinase IspE of the Non-Mevalonate Pathway for Isoprenoid Biosynthesis by Crane, Christine M., Hirsch, Anna K. H., Alphey, Magnus S., Sgraja, Tanja, Lauw, Susan, Illarionova, Victoria, Rohdich, Felix, Eisenreich, Wolfgang, Hunter, William N., Bacher, Adelbert, Diederich, François

“…The enzymes of the non‐mevalonate pathway for isoprenoid biosynthesis are attractive targets for the development of novel drugs against malaria and…”
Get full text

Characterization of Aquifex aeolicus 4‐diphosphocytidyl‐2 C ‐methyl‐ d ‐erythritol kinase – ligand recognition in a template for antimicrobial drug discovery by Sgraja, Tanja, Alphey, Magnus S., Ghilagaber, Stephanos, Marquez, Rudi, Robertson, Murray N., Hemmings, Jennifer L., Lauw, Susan, Rohdich, Felix, Bacher, Adelbert, Eisenreich, Wolfgang, Illarionova, Victoria, Hunter, William N.

“…4‐Diphosphocytidyl‐2 C ‐methyl‐ d ‐erythritol kinase (IspE) catalyses the ATP‐dependent conversion of 4‐diphosphocytidyl‐2 C ‐methyl‐ d ‐erythritol (CDPME) to…”
Get full text

Structural Insights into the Neuroprotective-acting Carbonyl Reductase Sniffer of Drosophila melanogaster by Sgraja, Tanja, Ulschmid, Julia, Becker, Katja, Schneuwly, Stephan, Klebe, Gerhard, Reuter, Klaus, Heine, Andreas

“…In vivo studies with the fruit-fly Drosophila melanogaster have shown that the Sniffer protein prevents age-dependent and oxidative stress-induced…”
Get full text

A double mutation of Escherichia coli 2C-methyl-d-erythritol-2,4-cyclodiphosphate synthase disrupts six hydrogen bonds with, yet fails to prevent binding of, an isoprenoid diphosphate by Sgraja, Tanja, Kemp, Lauris E., Ramsden, Nicola, Hunter, William N.

“…The essential enzyme 2C‐methyl‐d‐erythritol‐2,4‐cyclodiphosphate (MECP) synthase, found in most eubacteria and the apicomplexan parasites, participates in…”
Get full text

A double mutation of Escherichia coli 2 C -methyl- D -erythritol-2,4-cyclodiphosphate synthase disrupts six hydrogen bonds with, yet fails to prevent binding of, an isoprenoid diphosphate by Sgraja, Tanja, Kemp, Lauris E., Ramsden, Nicola, Hunter, William N.

Get full text

A double mutation of Escherichia coli2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase disrupts six hydrogen bonds with, yet fails to prevent binding of, an isoprenoid diphosphate by Sgraja, Tanja, Kemp, Lauris E, Ramsden, Nicola, Hunter, William N

“…The essential enzyme 2C-methyl-D-erythritol-2,4-cyclodiphosphate (MECP) synthase, found in most eubacteria and the apicomplexan parasites, participates in…”
Get full text