Search Results - "Sgourakis, Nikolaos"

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  1. 1

    Modeling an In-Register, Parallel “Iowa” Aβ Fibril Structure Using Solid-State NMR Data from Labeled Samples with Rosetta by Sgourakis, Nikolaos G., Yau, Wai-Ming, Qiang, Wei

    Published in Structure (London) (06-01-2015)
    “…Determining the structures of amyloid fibrils is an important first step toward understanding the molecular basis of neurodegenerative diseases. For β-amyloid…”
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    Atomic model of the type III secretion system needle by Loquet, Antoine, Sgourakis, Nikolaos G., Gupta, Rashmi, Giller, Karin, Riedel, Dietmar, Goosmann, Christian, Griesinger, Christian, Kolbe, Michael, Baker, David, Becker, Stefan, Lange, Adam

    Published in Nature (London) (14-06-2012)
    “…The structure of the needle of the type III secretion system of Salmonella typhimurium , used to inject virulence proteins into host cells during infection,…”
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  3. 3

    NMR–Rosetta capsid model of M13 bacteriophage reveals a quadrupled hydrophobic packing epitope by Morag, Omry, Sgourakis, Nikolaos G., Baker, David, Goldbourt, Amir

    “…Significance We present an atomic-resolution structure of the M13 filamentous bacteriophage capsid, one of many filamentous viruses that play important roles…”
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  4. 4

    High-resolution structure of the Shigella type-III secretion needle by solid-state NMR and cryo-electron microscopy by Demers, Jean-Philippe, Habenstein, Birgit, Loquet, Antoine, Kumar Vasa, Suresh, Giller, Karin, Becker, Stefan, Baker, David, Lange, Adam, Sgourakis, Nikolaos G.

    Published in Nature communications (29-09-2014)
    “…We introduce a general hybrid approach for determining the structures of supramolecular assemblies. Cryo-electron microscopy (cryo-EM) data define the overall…”
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  5. 5

    Dynamics of MHC-I molecules in the antigen processing and presentation pathway by Truong, Hau V, Sgourakis, Nikolaos G

    Published in Current opinion in immunology (01-06-2021)
    “…•MHC-I molecules exhibit allotype-dependent conformational flexibility, which is critical for their function.•Peptide-deficient MHC-I adopt distinct groove…”
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  6. 6

    Backbone-independent NMR resonance assignments of methyl probes in large proteins by Nerli, Santrupti, De Paula, Viviane S., McShan, Andrew C., Sgourakis, Nikolaos G.

    Published in Nature communications (29-01-2021)
    “…Methyl-specific isotope labeling is a powerful tool to study the structure, dynamics and interactions of large proteins and protein complexes by solution-state…”
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  7. 7

    Chemical shift-based methods in NMR structure determination by Nerli, Santrupti, McShan, Andrew C., Sgourakis, Nikolaos G.

    “…[Display omitted] •Ab initio fragment assembly guided by NMR chemical shifts.•Integration of chemical shifts with comparative and multi-domain modeling…”
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  8. 8

    HLA3DB: comprehensive annotation of peptide/HLA complexes enables blind structure prediction of T cell epitopes by Gupta, Sagar, Nerli, Santrupti, Kutti Kandy, Sreeja, Mersky, Glenn L., Sgourakis, Nikolaos G.

    Published in Nature communications (10-10-2023)
    “…The class I proteins of the major histocompatibility complex (MHC-I) display epitopic peptides derived from endogenous proteins on the cell surface for immune…”
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  9. 9

    TAPBPR promotes antigen loading on MHC-I molecules using a peptide trap by McShan, Andrew C., Devlin, Christine A., Morozov, Giora I., Overall, Sarah A., Moschidi, Danai, Akella, Neha, Procko, Erik, Sgourakis, Nikolaos G.

    Published in Nature communications (26-05-2021)
    “…Chaperones Tapasin and TAP-binding protein related (TAPBPR) perform the important functions of stabilizing nascent MHC-I molecules (chaperoning) and selecting…”
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    De novo design of a non-local β-sheet protein with high stability and accuracy by Marcos, Enrique, Chidyausiku, Tamuka M., McShan, Andrew C., Evangelidis, Thomas, Nerli, Santrupti, Carter, Lauren, Nivón, Lucas G., Davis, Audrey, Oberdorfer, Gustav, Tripsianes, Konstantinos, Sgourakis, Nikolaos G., Baker, David

    Published in Nature structural & molecular biology (01-11-2018)
    “…β-sheet proteins carry out critical functions in biology, and hence are attractive scaffolds for computational protein design. Despite this potential, de novo…”
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    Atomic-Level Characterization of the Ensemble of the Aβ(1–42) Monomer in Water Using Unbiased Molecular Dynamics Simulations and Spectral Algorithms by Sgourakis, Nikolaos G., Merced-Serrano, Myrna, Boutsidis, Christos, Drineas, Petros, Du, Zheming, Wang, Chunyu, Garcia, Angel E.

    Published in Journal of molecular biology (14-01-2011)
    “…Aβ(1–42) is the highly pathologic isoform of amyloid-β, the peptide constituent of fibrils and neurotoxic oligomers involved in Alzheimer's disease. Recent…”
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  14. 14

    The common structural architecture of Shigella flexneri and Salmonella typhimurium type three secretion needles by Demers, Jean-Philippe, Sgourakis, Nikolaos G, Gupta, Rashmi, Loquet, Antoine, Giller, Karin, Riedel, Dietmar, Laube, Britta, Kolbe, Michael, Baker, David, Becker, Stefan, Lange, Adam

    Published in PLoS pathogens (01-03-2013)
    “…The Type Three Secretion System (T3SS), or injectisome, is a macromolecular infection machinery present in many pathogenic Gram-negative bacteria. It consists…”
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    Conformational plasticity of RAS Q61 family of neoepitopes results in distinct features for targeted recognition by McShan, Andrew C., Flores-Solis, David, Sun, Yi, Garfinkle, Samuel E., Toor, Jugmohit S., Young, Michael C., Sgourakis, Nikolaos G.

    Published in Nature communications (11-12-2023)
    “…The conformational landscapes of peptide/human leucocyte antigen (pHLA) protein complexes encompassing tumor neoantigens provide a rationale for target…”
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    Structural mechanism of tapasin-mediated MHC-I peptide loading in antigen presentation by Jiang, Jiansheng, Taylor, Daniel K., Kim, Ellen J., Boyd, Lisa F., Ahmad, Javeed, Mage, Michael G., Truong, Hau V., Woodward, Claire H., Sgourakis, Nikolaos G., Cresswell, Peter, Margulies, David H., Natarajan, Kannan

    Published in Nature communications (17-09-2022)
    “…Loading of MHC-I molecules with peptide by the catalytic chaperone tapasin in the peptide loading complex plays a critical role in antigen presentation and…”
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  19. 19

    A refined model of the prototypical Salmonella SPI-1 T3SS basal body reveals the molecular basis for its assembly by Bergeron, Julien R C, Worrall, Liam J, Sgourakis, Nikolaos G, DiMaio, Frank, Pfuetzner, Richard A, Felise, Heather B, Vuckovic, Marija, Yu, Angel C, Miller, Samuel I, Baker, David, Strynadka, Natalie C J

    Published in PLoS pathogens (01-04-2013)
    “…The T3SS injectisome is a syringe-shaped macromolecular assembly found in pathogenic Gram-negative bacteria that allows for the direct delivery of virulence…”
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    Interleukin-2 druggability is modulated by global conformational transitions controlled by a helical capping switch by De Paula, Viviane S., Jude, Kevin M., Nerlie, Santrupti, Glassman, Caleb R., Garcia, K. Christopher, Sgourakis, Nikolaos G.

    “…Interleukin-2 (IL-2) is a small α-helical cytokine that regulates immune cell homeostasis through its recruitment to a high-affinity heterotrimeric receptor…”
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