Search Results - "Sgodda, Malte"

Hepatocyte differentiation of mesenchymal stem cells from rat peritoneal adipose tissue in vitro and in vivo by Sgodda, Malte, Aurich, Hendryk, Kleist, Sina, Aurich, Ines, König, Sarah, Dollinger, Matthias M., Fleig, Wolfgang E., Christ, Bruno

“…Mesenchymal tissues harbour stromal cells capable of multilineage differentiation. Here, we demonstrate the isolation of mesenchymal stem cells (MSC) from rat…”
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MicroRNA-199a-5p inhibition enhances the liver repopulation ability of human embryonic stem cell-derived hepatic cells by Möbus, Selina, Yang, Dakai, Yuan, Qinggong, Lüdtke, Timo H.-W, Balakrishnan, Asha, Sgodda, Malte, Rani, Bhavna, Kispert, Andreas, Araúzo-Bravo, Marcos J, Vogel, Arndt, Manns, Michael P, Ott, Michael, Cantz, Tobias, Sharma, Amar Deep

“…Background & Aims Current hepatic differentiation protocols for human embryonic stem cells (ESCs) require substantial improvements. MicroRNAs (miRNAs) have…”
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Synthetic Notch-Receptor-Mediated Transmission of a Transient Signal into Permanent Information via CRISPR/Cas9-Based Genome Editing by Sgodda, Malte, Alfken, Susanne, Schambach, Axel, Eggenschwiler, Reto, Fidzinski, Pawel, Hummel, Michael, Cantz, Tobias

“…Synthetic receptor biology and genome editing are emerging techniques, both of which are currently beginning to be used in preclinical and clinical…”
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Biphasic modulation of Wnt signaling supports efficient foregut endoderm formation from human pluripotent stem cells by Hoepfner, Jeannine, Kleinsorge, Mandy, Papp, Oliver, Ackermann, Mania, Alfken, Susanne, Rinas, Ursula, Solodenko, Wladimir, Kirschning, Andreas, Sgodda, Malte, Cantz, Tobias

“…Pluripotent stem cells (embryonic stem cells and induced pluripotent stem cells) are of great promise in regenerative medicine, including molecular studies of…”
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Optimal reprogramming factor stoichiometry increases colony numbers and affects molecular characteristics of murine induced pluripotent stem cells by Tiemann, Ulf, Sgodda, Malte, Warlich, Eva, Ballmaier, Matthias, Schöler, Hans R., Schambach, Axel, Cantz, Tobias

“…Somatic cells can be reprogrammed toward pluripotency by overexpression of a set of transcription factors, yielding induced pluripotent stem cells (iPSCs) with…”
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Sustained Knockdown of a Disease‐Causing Gene in Patient‐Specific Induced Pluripotent Stem Cells Using Lentiviral Vector‐Based Gene Therapy by Eggenschwiler, Reto, Loya, Komal, Wu, Guangming, Sharma, Amar Deep, Sgodda, Malte, Zychlinski, Daniela, Herr, Christian, Steinemann, Doris, Teckman, Jeffrey, Bals, Robert, Ott, Michael, Schambach, Axel, Schöler, Hans Robert, Cantz, Tobias

“…This study proposes an approach for the expression of a therapeutic short hairpin RNA (shRNA) in disease‐specific induced pluripotent stem cells (iPSCs) using…”
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Generation of healthy mice from gene-corrected disease-specific induced pluripotent stem cells by Wu, Guangming, Liu, Na, Rittelmeyer, Ina, Sharma, Amar Deep, Sgodda, Malte, Zaehres, Holm, Bleidissel, Martina, Greber, Boris, Gentile, Luca, Han, Dong Wook, Rudolph, Cornelia, Steinemann, Doris, Schambach, Axel, Ott, Michael, Schöler, Hans R, Cantz, Tobias

“…Using the murine model of tyrosinemia type 1 (fumarylacetoacetate hydrolase [FAH] deficiency; FAH⁻/⁻ mice) as a paradigm for orphan disorders, such as…”
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Efficient hematopoietic redifferentiation of induced pluripotent stem cells derived from primitive murine bone marrow cells by Pfaff, Nils, Lachmann, Nico, Kohlscheen, Saskia, Sgodda, Malte, Araúzo-Bravo, Marcos J, Greber, Boris, Kues, Wilfried, Glage, Silke, Baum, Christopher, Niemann, Heiner, Schambach, Axel, Cantz, Tobias, Moritz, Thomas

“…Heterogeneity among induced pluripotent stem cell (iPSC) lines with regard to their gene expression profile and differentiation potential has been described…”
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Bronchoalveolar sublineage specification of pluripotent stem cells: effect of dexamethasone plus cAMP-elevating agents and keratinocyte growth factor by Katsirntaki, Katherina, Mauritz, Christina, Olmer, Ruth, Schmeckebier, Sabrina, Sgodda, Malte, Puppe, Verena, Eggenschwiler, Reto, Duerr, Julia, Schubert, Susanne C, Schmiedl, Andreas, Ochs, Matthias, Cantz, Tobias, Salwig, Isabelle, Szibor, Marten, Braun, Thomas, Rathert, Christian, Martens, Andreas, Mall, Marcus A, Martin, Ulrich

“…Respiratory progenitors can be efficiently generated from pluripotent stem cells (PSCs). However, further targeted differentiation into bronchoalveolar…”
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Hepatic Differentiation of Murine Disease-Specific Induced Pluripotent Stem Cells Allows Disease Modelling In Vitro by Eggenschwiler, Reto, Loya, Komal, Sgodda, Malte, André, Francoise, Cantz, Tobias

“…Direct reprogramming of somatic cells into pluripotent cells by retrovirus-mediated expression of OCT4, SOX2, KLF4, and C-MYC is a promising approach to derive…”
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Small but Significant: Inter- and Intrapatient Variations in iPS Cell–based Disease Modeling by Sgodda, Malte, Cantz, Tobias

“…Last year the Nobel Prize in Physiology or Medicine was awarded to John B. Gurdon and Shinya Yamanaka for their groundbreaking research on reprogramming of…”
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Comparison of the activity and pluripotency maintaining potential of human leukemia inhibitory factor (LIF) produced in E.coli and CHO cells by Haake, Claas, Bonk, Sophia, Parsiegla, Jana, Tomala, Magda, Loya, Komal, Sgodda, Malte, Cantz, Tobias, Schambach, Axel, Kasper, Cornelia, Scheper, Thomas

“…From: 22nd European Society for Animal Cell Technology (ESACT) Meeting on Cell Based Technologies Vienna, Austria 15-18 May 2011 Author details1-Institute for…”
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A Scalable Approach for the Generation of Human Pluripotent Stem Cell-Derived Hepatic Organoids with Sensitive Hepatotoxicity Features by Sgodda, Malte, Dai, Zhen, Zweigerdt, Robert, Sharma, Amar Deep, Ott, Michael, Cantz, Tobias

“…The quest for physiologically active human hepatocyte-like cells for in vitro research and drug screening is high. The recent progress in the field of…”
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KIF12 Variants and Disturbed Hepatocyte Polarity in Children with a Phenotypic Spectrum of Cholestatic Liver Disease by Stalke, Amelie, Sgodda, Malte, Cantz, Tobias, Skawran, Britta, Lainka, Elke, Hartleben, Björn, Baumann, Ulrich, Pfister, Eva-Doreen

“…KIF12 has been identified as a cholestasis-associated candidate gene. We describe 6 cases from 4 unrelated families with diverse cholestatic phenotypes…”
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Chemically-Defined, Xeno-Free, Scalable Production of hPSC-Derived Definitive Endoderm Aggregates with Multi-Lineage Differentiation Potential by Sahabian, Anais, Sgodda, Malte, Naujok, Ortwin, Dettmer, Rabea, Dahlmann, Julia, Manstein, Felix, Cantz, Tobias, Zweigerdt, Robert, Martin, Ulrich, Olmer, Ruth

“…For the production and bio-banking of differentiated derivatives from human pluripotent stem cells (hPSCs) in large quantities for drug screening and cellular…”
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Glycomic Characterization of Induced Pluripotent Stem Cells Derived from a Patient Suffering from Phosphomannomutase 2 Congenital Disorder of Glycosylation (PMM2-CDG) by Thiesler, Christina T., Cajic, Samanta, Hoffmann, Dirk, Thiel, Christian, van Diepen, Laura, Hennig, René, Sgodda, Malte, Weiβmann, Robert, Reichl, Udo, Steinemann, Doris, Diekmann, Ulf, Huber, Nicolas M.B., Oberbeck, Astrid, Cantz, Tobias, Kuss, Andreas W., Körner, Christian, Schambach, Axel, Rapp, Erdmann, Buettner, Falk F.R.

“…PMM2-CDG, formerly known as congenital disorder of glycosylation-Ia (CDG-Ia), is caused by mutations in the gene encoding phosphomannomutase 2 (PMM2). This…”
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In vitro modelling of familial amyloidotic polyneuropathy allows quantitative detection of transthyretin amyloid fibril-like structures in hepatic derivatives of patient-specific induced pluripotent stem cells by Hoepfner, Jeannine, Kleinsorge, Mandy, Papp, Oliver, Alfken, Susanne, Heiringhoff, Robin, Pich, Andreas, Sauer, Vanessa, Zibert, Andree, Göhring, Gudrun, Schmidt, Hartmut, Sgodda, Malte, Cantz, Tobias

“…The transthyretin protein is thermodynamically destabilised by mutations in the transthyretin gene, promoting the formation of amyloid fibrils in various…”
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Keratinocyte growth factor and dexamethasone plus elevated cAMP levels synergistically support pluripotent stem cell differentiation into alveolar epithelial type II cells by Schmeckebier, Sabrina, Mauritz, Christina, Katsirntaki, Katherina, Sgodda, Malte, Puppe, Verena, Duerr, Julia, Schubert, Susanne C, Schmiedl, Andreas, Lin, Qiong, Paleček, Jiri, Draeger, Gerald, Ochs, Matthias, Zenke, Martin, Cantz, Tobias, Mall, Marcus A, Martin, Ulrich

“…Alveolar epithelial type II (ATII)-like cells can be generated from murine embryonic stem cells (ESCs), although to date, no robust protocols applying specific…”
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Hepatic differentiation of pluripotent stem cells by Loya, Komal, Eggenschwiler, Reto, Ko, Kinarm, Sgodda, Malte, André, Francoise, Bleidissel, Martina, Schöler, Hans R, Cantz, Tobias

“…In regenerative medicine pluripotent stem cells are considered to be a valuable self-renewing source for therapeutic cell transplantations, given that a…”
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Improved lentiviral gene transfer into human embryonic stem cells grown in co-culture with murine feeder and stroma cells by Wurm, Melanie, Gross, Benjamin, Sgodda, Malte, Ständker, Ludger, Müller, Thomas, Forssmann, Wolf-Georg, Horn, Peter A, Blasczyk, Rainer, Cantz, Tobias

“…Genetic modification of human embryonic stem cells (hESCs) using biophysical DNA transfection methods are hampered by the very low single cell survival rate…”
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