Search Results - "Seznec, H."

Advances in microbeam technologies and applications to radiation biology by Barberet, P, Seznec, H

“…Charged-particle microbeams (CPMs) allow the targeting of sub-cellular compartments with a counted number of energetic ions. While initially developed in the…”
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Electric Fields in Liquid Water Irradiated with Protons at Ultrahigh Dose Rates by Gobet, F., Barberet, P., Delville, M.-H., Devès, G., Guérin, T., Liénard, R., Tran, H. N., Vecco-Garda, C., Würger, A., Zein, S., Seznec, H.

“…We study the effects of irradiating water with 3 MeV protons at high doses by observing the motion of charged polystyrene beads outside the proton beam. By…”
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X-ray photons produced from a plasma-cathode electron beam for radiation biology applications by Gobet, F., Barberet, P., Courtois, L., Deves, G., Gardelle, J., Leblanc, S., Plawinski, L., Seznec, H.

“…A compact low-energy and high-intensity x-ray source for radiation biology applications is presented. A laser-induced plasma moves inside a 30 kV diode and…”
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Development and applications of STIM- and PIXE-tomography: A review by Michelet, C., Barberet, P., Moretto, P., Seznec, H.

“…In combination with nuclear microprobes, STIM and PIXE tomography offer non-destructive quantitative three-dimensional characterization of microscopic samples…”
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Monte-Carlo dosimetry on a realistic cell monolayer geometry exposed to alpha particles by Barberet, Ph, Vianna, F, Karamitros, M, Brun, T, Gordillo, N, Moretto, Ph, Incerti, S, Seznec, H

“…The energy and specific energy absorbed in the main cell compartments (nucleus and cytoplasm) in typical radiobiology experiments are usually estimated by…”
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Advances in microbeam technologies and applications to radiation biology: Table 1 by Barberet, P., Seznec, H.

“…Charged-particle microbeams (CPMs) allow the targeting of sub-cellular compartments with a counted number of energetic ions. While initially developed in the…”
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Idebenone delays the onset of cardiac functional alteration without correction of Fe-S enzymes deficit in a mouse model for Friedreich ataxia by Seznec, Hervé, Simon, Delphine, Monassier, Laurent, Criqui-Filipe, Paola, Gansmuller, Anne, Rustin, Pierre, Koenig, Michel, Puccio, Hélène

“…Friedreich ataxia (FRDA), a progressive neurodegenerative disorder associated with cardiomyopathy, is caused by severely reduced frataxin, a mitochondrial…”
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Comparison of experimental proton-induced fluorescence spectra for a selection of thin high-Z samples with Geant4 Monte Carlo simulations by Incerti, S., Barberet, Ph, Dévès, G., Michelet, C., Francis, Z., Ivantchenko, V., Mantero, A., El Bitar, Z., Bernal, M.A., Tran, H.N., Karamitros, M., Seznec, H.

“…The general purpose Geant4 Monte Carlo simulation toolkit is able to simulate radiative and non-radiative atomic de-excitation processes such as fluorescence…”
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Simulating radial dose of ion tracks in liquid water simulated with Geant4-DNA: A comparative study by Incerti, S., Psaltaki, M., Gillet, P., Barberet, Ph, Bardiès, M., Bernal, M.A., Bordage, M.-C., Breton, V., Davidkova, M., Delage, E., El Bitar, Z., Francis, Z., Guatelli, S., Ivanchenko, A., Ivanchenko, V., Karamitros, M., Lee, S.B., Maigne, L., Meylan, S., Murakami, K., Nieminen, P., Payno, H., Perrot, Y., Petrovic, I., Pham, Q.T., Ristic-Fira, A., Santin, G., Sasaki, T., Seznec, H., Shin, J.I., Stepan, V., Tran, H.N., Villagrasa, C.

“…An accurate modeling of radial energy deposition around ion tracks is a key requirement of radiation transport software used for simulations in radiobiology at…”
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First results obtained using the CENBG nanobeam line: Performances and applications by Barberet, Ph, Daudin, L., Gordillo, N., Sorieul, S., Simon, M., Seznec, H., Idarraga, I., Incerti, S., Balana, A., Moretto, Ph

“…A high resolution focused beam line has been recently installed on the AIFIRA (“Applications Interdisciplinaires des Faisceaux d’Ions en Région Aquitaine”)…”
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Monte Carlo dosimetry for targeted irradiation of individual cells using a microbeam facility by Incerti, S., Seznec, H., Simon, M., Barberet, Ph, Habchi, C., Moretto, Ph

“…Microbeam facilities provide a unique opportunity to investigate the effects of ionising radiation on living biological cells with a precise control of the…”
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Cobalt distribution in keratinocyte cells indicates nuclear and perinuclear accumulation and interaction with magnesium and zinc homeostasis by Ortega, Richard, Bresson, Carole, Fraysse, Aurélien, Sandre, Caroline, Devès, Guillaume, Gombert, Clémentine, Tabarant, Michel, Bleuet, Pierre, Seznec, Hervé, Simionovici, Alexandre, Moretto, Philippe, Moulin, Christophe

“…Cobalt is known to be toxic at high concentration, to induce contact dermatosis, and occupational radiation skin damage because of its use in nuclear industry…”
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An ImageJ plugin for ion beam imaging and data processing at AIFIRA facility by Devès, G., Daudin, L., Bessy, A., Buga, F., Ghanty, J., Naar, A., Sommar, V., Michelet, C., Seznec, H., Barberet, P.

“…Quantification and imaging of chemical elements at the cellular level requires the use of a combination of techniques such as micro-PIXE, micro-RBS, STIM,…”
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Quantitative reconstruction of PIXE-tomography data for thin samples using GUPIX X-ray emission yields by Michelet, C., Barberet, Ph, Devès, G., Bouguelmouna, B., Bourret, S., Delville, M.-H., Le Trequesser, Q., Gordillo, N., Beasley, D.G., Marques, A.C., Farau, R., Toko, B.R., Campbell, J., Maxwell, J., Moretto, Ph, Seznec, H.

“…We present here a new development of the TomoRebuild software package, to perform quantitative Particle Induced X-ray Emission Tomography (PIXET)…”
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A comparison of quantitative reconstruction techniques for PIXE-tomography analysis applied to biological samples by Beasley, D.G., Alves, L.C., Barberet, Ph, Bourret, S., Devès, G., Gordillo, N., Michelet, C., Le Trequesser, Q., Marques, A.C., Seznec, H., da Silva, R.C.

“…The tomographic reconstruction of biological specimens requires robust algorithms, able to deal with low density contrast and low element concentrations. At…”
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Mice transgenic for the human myotonic dystrophy region with expanded CTG repeats display muscular and brain abnormalities by SEZNEC, Hervé, AGBULUT, Onnik, FOUQUET, Coralie, BUTLER-BROWNE, Gillian, DELACOURTE, André, JUNIEN, Claudine, GOURDON, Geneviève, SERGEANT, Nicolas, SAVOURET, Cédric, GHESTEM, Antoine, TABTI, Nacira, WILLER, Jean-Claude, OURTH, Lucie, DUROS, Chantal, BRISSON, Edith

“…The autosomal dominant mutation causing myotonic dystrophy (DM1) is a CTG repeat expansion in the 3'-UTR of the DM protein kinase (DMPK) gene. This…”
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Technical developments for computed tomography on the CENBG nanobeam line by Gordillo, N., Habchi, C., Daudin, L., Sakellariou, A., Delalée, F., Barberet, Ph, Incerti, S., Seznec, H., Moretto, Ph

“…The use of ion microbeams as probes for computed tomography has proven to be a powerful tool for the three-dimensional characterization of specimens a few tens…”
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Friedreich ataxia: the oxidative stress paradox by Seznec, Hervé, Simon, Delphine, Bouton, Cécile, Reutenauer, Laurence, Hertzog, Ariane, Golik, Pawel, Procaccio, Vincent, Patel, Manisha, Drapier, Jean-Claude, Koenig, Michel, Puccio, Hélène

“…Friedreich ataxia (FRDA) results from a generalized deficiency of mitochondrial and cytosolic iron–sulfur protein activity initially ascribed to mitochondrial…”
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Transgenic mice carrying large human genomic sequences with expanded CTG repeat mimic closely the DM CTG repeat intergenerational and somatic instability by SEZNEC, H, LIA-BALDINI, A.-S, DUROS, C, FOUQUET, C, LACROIX, C, HOFMANN-RADVANYI, H, JUNIEN, C, GOURDON, G

“…Myotonic dystrophy (DM) is caused by a CTG repeat expansion in the 3'UTR of the DM protein kinase (DMPK) gene. A very high level of instability is observed…”
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Monte Carlo simulation of the CENBG microbeam and nanobeam lines with the Geant4 toolkit by Incerti, S., Zhang, Q., Andersson, F., Moretto, Ph, Grime, G.W., Merchant, M.J., Nguyen, D.T., Habchi, C., Pouthier, T., Seznec, H.

“…A single-ended HVEE ® 3.5 MV Singletron electrostatic accelerator has been installed since October 2005 at the Centre d’Etudes Nucléaires de Bordeaux-Gradignan…”
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