Search Results - "Sezen, Sena"

Riluzole, a neuroprotective agent, preserves erectile function following bilateral cavernous nerve injury in male rats by Barut, Elif Nur, Engin, Seckin, Yasar, Yesim Kaya, Sezen, Sena F.

“…Neurogenic erectile dysfunction is a highly prevalent complication in men undergoing radical prostatectomy. The underlying mechanisms remain incompletely…”
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DL-EDOF: Novel Multi-Focus Image Data Set and Deep Learning-Based Approach for More Accurate and Specimen-Free Extended Depth of Focus by Dogan, Hulya, Dogan, Ramazan Ozgur, Ay, Ilyas, Sezen, Sena F

“…Depth of focus (DOF) is defined as the axial range in which the specimen stage moves without losing focus while the imaging apparatus remains stable. It may…”
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Trimetazidine attenuates cyclophosphamide-induced cystitis by inhibiting TLR4-mediated NFκB signaling in mice by Engin, Seçkin, Barut, Elif Nur, Yaşar, Yeşim Kaya, Soysal, Aysun Çelik, Arıcı, Tuğba, Kerimoğlu, Gökçen, Kadıoğlu, Mine, Sezen, Sena F.

“…Cyclophosphamide (CP)-induced cystitis is a challenging clinical problem involving inflammation and dysfunction of bladder. Trimetazidine (TMZ) is an…”
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Cyclic AMP-dependent phosphorylation of neuronal nitric oxide synthase mediates penile erection by Hurt, K. Joseph, Sezen, Sena F., Lagoda, Gwen F., Musicki, Biljana, Rameau, Gerald A., Snyder, Solomon H., Burnett, Arthur L.

“…Nitric oxide (NO) generated by neuronal NO synthase (nNOS) initiates penile erection, but has not been thought to participate in the sustained erection…”
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Niclosamide attenuates erectile dysfunction and corporal fibrosis via reversal of Smad signaling in diabetic rat model by Engin, Seçkin, Barut, Elif Nur, Kaya Yaşar, Yeşim, Işık, Semanur, Kerimoğlu, Gökçen, Burnett, Arthur L, Sezen, Sena F

“…Diabetes mellitus-induced erectile dysfunction (DMED) is a common urological complication of diabetes, and current drugs often fail to provide an effective…”
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The inhibitory effect of trimetazidine on detrusor contractility - a potential repositioning of trimetazidine for the treatment of overactive bladder by Engin, Seckin, Kaya Yasar, Yesim, Barut, Elif Nur, Getboga, Damla, Erac, Yasemin, Sezen, Sena F

“…This study aimed to identify the effect of trimetazidine (TMZ), an antianginal drug, on detrusor smooth muscle (DSM) contractility and its possible mechanisms…”
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Dual Strategy with Adipose-Derived Stem Cells and l-arginine Recovered Cavernosal Functions in a Rat Model of Radical Prostatectomy by Yilmaz-Oral, Didem, Sezen, Sena F, Turkcan, Damla, Asker, Heba, Kaya-Sezginer, Ecem, Kirlangic, Omer Faruk, Kopru, Cagla Zubeyde, Elci, Mualla Pınar, Ozen, Fatma Zeynep, Korkusuz, Petek, Oren, Sema, Oztekin, Cetin Volkan, Ates, Ilker, Gur, Serap

“…As standard therapy for prostate cancer, radical prostatectomy causes cavernous nerve (CN) injury and increases fibrosis and hypoxia-induced penile structural…”
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The contribution of the WNT pathway to the therapeutic effects of montelukast in experimental murine airway inflammation induced by ovalbumin and lipopolysaccharide by Kaya‐Yasar, Yesim, Engin, Seckin, Barut, Elif Nur, Inan, Cihan, Saygin, Ismail, Erkoseoglu, Ilknur, Sezen, Sena F.

“…The wingless/integrase‐1 (WNT) pathway involved in the pathogenesis of inflammatory airway diseases has recently generated considerable research interest…”
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Improved Endothelium-Dependent Relaxation of Thoracic Aorta in Niclosamide-Treated Diabetic Rats by Engin, Seckin, Yasar, Yesim Kaya, Barut, Elif Nur, Sezen, Sena F.

“…Diabetes‐induced endothelial dysfunction is critical for the development of diabetic cardiovascular complications. The aim of this study was to investigate the…”
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Alpha‐lipoic acid: A promising adjuvant for nonsteroidal anti‐inflammatory drugs therapy with improved efficacy and gastroprotection by Barut, Elif Nur, Engin, Seçkin, Saygın, İsmail, Kaya‐Yasar, Yesim, Arici, Seyma, Sezen, Sena F.

“…Nonsteroidal anti‐inflammatory drugs (NSAIDs) are commonly used in a wide variety of diseases due to their analgesic and anti‐inflammatory effects, but their…”
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Double benefit of metformin treatment: improved bladder function in cyclophosphamide-induced cystitis and enhanced cytotoxicity in cancer cells by Engin, Seckin, Barut, Elif Nur, Soysal, Aysun Celik, Keskin, Oguzhan, Kerimoglu, Gokcen, Kadioglu, Mine, Sezen, Sena

“…Cyclophosphamide (CP) is a widely used anti-neoplastic drug; however, it leads to bladder dysfunction in the form of hemorrhagic cystitis that is a serious…”
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Photodynamic therapy effect of morpholinium containing silicon (IV) phthalocyanine on HCT-116 cells by Yalçın, Can Özgür, Barut, Burak, Barut, Elif Nur, Demirbaş, Ümit, Dinçer, Tuba, Engin, Seçkin, Özel, Arzu, Sena Sezen, F.

“…[Display omitted] •SiPc has a high singlet oxygen quantum yield and photodegradation quantum yield.•SiPc has a phototoxic effect on HCT-116 cells.•SiPc induced…”
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Molecular analysis of erection regulatory factors in sickle cell disease associated priapism in the human penis by Lagoda, Gwen, Sezen, Sena F, Cabrini, Marcelo R, Musicki, Biljana, Burnett, Arthur L

“…Priapism is a vasculopathy that occurs in approximately 40% of patients with sickle cell disease. Mouse models suggest that dysregulated nitric oxide synthase…”
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Hypercholesterolemia-Induced Erectile Dysfunction: Endothelial Nitric Oxide Synthase (eNOS) Uncoupling in the Mouse Penis by NAD(P)H Oxidase by Musicki, Biljana, Liu, Tongyun, Lagoda, Gwen A., Strong, Travis D., Sezen, Sena F., Johnson, Justin M., Burnett, Arthur L.

“…Hypercholesterolemia induces erectile dysfunction (ED) mostly by increasing oxidative stress and impairing endothelial function in the penis, but the…”
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Losartan preserves erectile function after bilateral cavernous nerve injury via antifibrotic mechanisms in male rats by Canguven, Onder, Lagoda, Gwen, Sezen, Sena F, Burnett, Arthur L

“…Angiotensin II is a known mediator of smooth muscle vasoconstriction and fibrosis. It up-regulates thrombospondin-1, a major activator of latent transforming…”
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Sustained nitric oxide (NO)‐releasing compound reverses dysregulated NO signal transduction in priapism by Lagoda, Gwen, Sezen, Sena F., Hurt, K. Joseph, Cabrini, Marcelo R., Mohanty, Dillip K., Burnett, Arthur L.

“…We evaluated the therapeutic potential of a sustained nitric oxide (NO)‐releasing compound to correct the molecular hallmarks and pathophysiology of priapism,…”
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Hydroxyl Fasudil, an Inhibitor of Rho Signaling, Improves Erectile Function in Diabetic Rats: A Role for Neuronal ROCK by Sezen, Sena F., Lagoda, Gwen, Musicki, Biljana, Burnett, Arthur L.

“…The pathogenesis of diabetic erectile dysfunction (ED) includes neuropathy, but the molecular basis for neurogenic ED is incompletely understood. The RhoA/ROCK…”
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Targeting NADPH Oxidase Decreases Oxidative Stress in the Transgenic Sickle Cell Mouse Penis by Musicki, Biljana, Liu, Tongyun, Sezen, Sena F., Burnett, Arthur L.

“…Sickle cell disease (SCD) is a state of chronic vasculopathy characterized by endothelial dysfunction and increased oxidative stress, but the sources and…”
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Investigation of the Antioxidant, α-Glucosidase Inhibitory, Anti-inflammatory, and DNA Protective Properties of Vaccinium arctostaphylos L by Barut, Burak, Barut, Elif Nur, Engin, Seçkin, Özel, Arzu, Sezen, Feride Sena

“…The scope of this study was to investigate the total phenolic, anthocyanin, and flavonoid contents and the biological properties of ethanol extract (EE),…”
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Neuronal nitric oxide signaling regulates erection recovery after cavernous nerve injury by Sezen, Sena F, Lagoda, Gwen, Burnett, Arthur L

“…Nitric oxide is the major neuronal mediator of penile erection but its role in erectile function status after cavernous nerve injury is uncertain. We…”
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