Search Results - "Seynhaeve, Ann L. B."

Cationic Thermosensitive Liposomes: A Novel Dual Targeted Heat-Triggered Drug Delivery Approach for Endothelial and Tumor Cells by Dicheva, Bilyana M, Hagen, Timo L. M. ten, Li, Li, Schipper, Debby, Seynhaeve, Ann L. B, Rhoon, Gerard C. van, Eggermont, Alexander M. M, Lindner, Lars H, Koning, Gerben A

“…Developing selectively targeted and heat-responsive nanocarriers holds paramount promises in chemotherapy. We show that this can be achieved by designing…”
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An adapted dorsal skinfold model used for 4D intravital followed by whole-mount imaging to reveal endothelial cell–pericyte association by Seynhaeve, Ann L. B., ten Hagen, Timo L. M.

“…Endothelial cells and pericytes are highly dynamic vascular cells and several subtypes, based on their spatiotemporal dynamics or molecular expression, are…”
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Lipid-based nanosystems: the next generation of cancer immune therapy by Cheng, Ziyun, Fobian, Seth-Frerich, Gurrieri, Elena, Amin, Mohamadreza, D'Agostino, Vito Giuseppe, Falahati, Mojtaba, Zalba, Sara, Debets, Reno, Garrido, María J, Saeed, Mesha, Seynhaeve, Ann L B, Balcioglu, Hayri E, Ten Hagen, Timo L M

“…Immunotherapy has become an important part of the oncotherapy arsenal. Its applicability in various cancer types is impressive, as well as its use of…”
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Liposomal Drug Delivery Systems for Cancer Therapy: The Rotterdam Experience by Amin, Mohamadreza, Seynhaeve, Ann L. B, Sharifi, Majid, Falahati, Mojtaba, ten Hagen, Timo L. M

“…At the Nanomedicine Innovation Center (NICE) at the Erasmus MC in Rotterdam, we have approached the treatment of cancer by starting with a vision of first…”
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Enhanced Specificity and Drug Delivery in Tumors by cRGD - Anchoring Thermosensitive Liposomes by Dicheva, Bilyana M., ten Hagen, Timo L. M., Seynhaeve, Ann L. B., Amin, Mohamadreza, Eggermont, Alexander M. M., Koning, Gerben A.

“…Purpose To develop RGD-targeted thermosensitive liposomes with increased tumor retention, improving drug release efficiency upon mild hyperthermia (HT) in both…”
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Drug transport kinetics of intravascular triggered drug delivery systems by ten Hagen, Timo L. M., Dreher, Matthew R., Zalba, Sara, Seynhaeve, Ann L. B., Amin, Mohamadreza, Li, Li, Haemmerich, Dieter

“…Intravascular triggered drug delivery systems (IV-DDS) for local drug delivery include various stimuli-responsive nanoparticles that release the associated…”
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A microcarrier-based spheroid 3D invasion assay to monitor dynamic cell movement in extracellular matrix by Liu, Hui, Lu, Tao, Kremers, Gert-Jan, Seynhaeve, Ann L B, Ten Hagen, Timo L M

“…Cell invasion through extracellular matrix (ECM) is a critical step in tumor metastasis. To study cell invasion in vitro, the internal microenvironment can be…”
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Pharmacokinetics, Tissue Distribution and Therapeutic Effect of Cationic Thermosensitive Liposomal Doxorubicin Upon Mild Hyperthermia by Dicheva, Bilyana M., Seynhaeve, Ann L. B., Soulie, Thomas, Eggermont, Alexander M. M., ten Hagen, Timo L. M., Koning, Gerben A.

“…Purpose To evaluate pharmacokinetic profile, biodistribution and therapeutic effect of cationic thermosensitive liposomes (CTSL) encapsulating doxorubicin…”
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Tumor necrosis factor α mediates homogeneous distribution of liposomes in murine melanoma that contributes to a better tumor response by SEYNHAEVE, Ann L. B, HOVING, Saske, SCHIPPER, Debby, VERMEULEN, Cindy E, DE WIEL-AMBAGTSHEER, Gisela Aan, VAN TIEL, Sandra T, EGGERMONT, Alexander M. M, TEN HAGEN, Timo L. M

“…Successful treatment of solid tumors with chemotherapeutics requires that adequate levels reach the tumor cells. Tumor vascular normalization has been proposed…”
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Improving Intracellular Doxorubicin Delivery Through Nanoliposomes Equipped with Selective Tumor Cell Membrane Permeabilizing Short-Chain Sphingolipids by Pedrosa, Lília R. Cordeiro, van Hell, Albert, Süss, Regine, van Blitterswijk, Wim J., Seynhaeve, Ann L. B., van Cappellen, Wiggert A., Eggermont, Alexander M. M., ten Hagen, Timo L. M., Verheij, Marcel, Koning, Gerben A.

“…Purpose To improve nanoliposomal-doxorubicin (DoxNL) delivery in tumor cells using liposome membrane-incorporated short-chain sphingolipids (SCS) with…”
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Red wine extract protects against oxidative-stress-induced endothelial senescence by Botden, Ilse P G, Oeseburg, Hisko, Durik, Matej, Leijten, Frank P J, Van Vark-Van Der Zee, Leonie C, Musterd-Bhaggoe, Usha M, Garrelds, Ingrid M, Seynhaeve, Ann L B, Langendonk, Janneke G, Sijbrands, Eric J G, Danser, A H Jan, Roks, Anton J M

“…Red wine polyphenols may preserve endothelial function during aging. Endothelial cell senescence enhances age-related endothelial dysfunction. We investigated…”
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Hyperthermia and Temperature-Sensitive Nanomaterials for Spatiotemporal Drug Delivery to Solid Tumors by Amin, Mohamadreza, Huang, Wenqiu, Seynhaeve, Ann L B, Ten Hagen, Timo L M

“…Nanotechnology has great capability in formulation, reduction of side effects, and enhancing pharmacokinetics of chemotherapeutics by designing stable or long…”
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Targeted and heat-triggered doxorubicin delivery to tumors by dual targeted cationic thermosensitive liposomes by Dicheva, Bilyana M., ten Hagen, Timo L.M., Schipper, Debby, Seynhaeve, Ann L.B., van Rhoon, Gerard C., Eggermont, Alexander M.M., Koning, Gerben A.

“…Liposomal nanoparticles can circumvent toxicity of encapsulated chemotherapeutic drugs, but fall short in tumor-specific and efficient intracellular drug…”
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Liposomes targeted to MHC-restricted antigen improve drug delivery and antimelanoma response by Saeed, Mesha, Zalba, Sara, Seynhaeve, Ann L B, Debets, Reno, Ten Hagen, Timo L M

“…Melanoma is the most aggressive form of skin cancer. Chemotherapy at a late stage fails due to low accumulation in tumors, indicating the need for targeted…”
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Differential TIMP3 expression affects tumor progression and angiogenesis in melanomas through regulation of directionally persistent endothelial cell migration by Das, Asha M., Seynhaeve, Ann L. B., Rens, Joost A. P., Vermeulen, Cindy E., Koning, Gerben A., Eggermont, Alexander M. M., ten Hagen, Timo L. M.

“…The angiogenic potential of solid tumors, or the ability to initiate neovasculature development from pre-existing host vessels, is facilitated by soluble…”
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Angiogenesis: A prognostic determinant in pancreatic cancer? by van der Zee, Jill A, van Eijck, Casper H.J, Hop, Wim C.J, van Dekken, Herman, Dicheva, Bilyana M, Seynhaeve, Ann L.B, Koning, Gerben A, Eggermont, Alexander M.M, ten Hagen, Timo L.M

“…Abstract Angiogenesis has been associated with disease progression in many solid tumours, however the statement that tumours need angiogenesis to grow, invade…”
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Vasoactive peptides upregulate mRNA expression and secretion of vascular endothelial growth factor in human airway smooth muscle cells by Alagappan, Vijay K T, Willems-Widyastuti, Anna, Seynhaeve, Ann L B, Garrelds, Ingrid M, ten Hagen, Timo L M, Saxena, Pramod R, Sharma, Hari S

“…Airway remodeling and associated angiogenesis are documented features of asthma, of which the molecular mechanisms are not fully understood. Angiotensin…”
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Daily Red Wine Consumption Improves Vascular Function by a Soluble Guanylyl Cyclase-Dependent Pathway by Botden, Ilse P.G., Langendonk, Janneke G., Meima, Marcel E., Boomsma, Frans, Seynhaeve, Ann L.B., Hagen, Timo L.M. ten, Danser, A.H. Jan, Sijbrands, Eric J.G.

“…Background Polyphenols in red wine are supposed to improve endothelial function. We investigated whether daily red wine consumption improves in-vivo vascular…”
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Bcl-2 associated anthanogen-1 (Bag-1) expression and prognostic value in pancreatic head and periampullary cancer by van der Zee, Jill A, ten Hagen, Timo L.M, Hop, Wim C.J, van Dekken, Herman, Dicheva, Bilyana M, Seynhaeve, Ann L.B, Koning, Gerben A, Eggermont, Alexander M.M, van Eijck, Casper H.J

“…Abstract The expression of anti-apoptosis gene Bcl-2 associated anthanogen-1 (Bag-1), has been associated with outcome in several cancer types, however its…”
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Differential expression and prognostic value of HMGA1 in pancreatic head and periampullary cancer by van der Zee, Jill A, ten Hagen, Timo L.M, Hop, Wim C.J, van Dekken, Herman, Dicheva, Bilyana M, Seynhaeve, Ann L.B, Koning, Gerben A, Eggermont, Alexander M.M, van Eijck, Casper H.J

“…Abstract The high mortality rate and minimal progress made in the treatment of pancreatic cancer over the last few decades, warrant an alternative approach…”
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