Search Results - "Seymour, MT"

DNA markers predicting benefit from adjuvant fluorouracil in patients with colon cancer: a molecular study by Barratt, PL, Seymour, MT, Stenning, SP, Georgiades, I, Walker, C, Birbeck, K, Quirke, P

“…Present clinical algorithms assign adjuvant chemotherapy according to prognosis, but clinical decisionmaking would be greatly improved if reliable predictive…”
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Comparison of intermittent and continuous palliative chemotherapy for advanced colorectal cancer: a multicentre randomised trial by Maughan, TS, James, RD, Kerr, DJ, Ledermann, JA, Seymour, MT, Topham, C, McArdle, C, Cain, D, Stephens, RJ

“…Policies of UK clinicians regarding the duration of chemotherapy for patients with advanced colorectal cancer are not consistent. We aimed to compare…”
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A 'modified de Gramont' regimen of fluorouracil, alone and with oxaliplatin, for advanced colorectal cancer by CHEESEMAN, S. L, JOEL, S. P, CHESTER, J. D, WILSON, G, DENT, J. T, RICHARDS, F. J, SEYMOUR, M. T

“…The standard de Gramont (dG) regimen of fortnightly leucovorin, bolus fluorouracil and 22-h infusion of fluorouracil, d1+2, and the same regimen plus…”
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Comparison of survival, palliation, and quality of life with three chemotherapy regimens in metastatic colorectal cancer: a multicentre randomised trial by Maughan, TS, James, RD, Kerr, DJ, Ledermann, JA, McArdle, C, Seymour, MT, Cohen, D, Hopwood, P, Johnston, C, Stephens, RJ

“…This randomised trial compared three chemotherapy regimens in the first-line treatment of advanced colorectal cancer, in terms of their effect on overall and…”
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Non-operative management of the primary tumour in patients with incurable stage IV colorectal cancer by Sarela, A. I., Guthrie, J. A., Seymour, M. T., Ride, E., Guillou, P. J., O'Riordain, D. S.

“…Background: Excision of primary colorectal cancer associated with irresectable synchronous metastases confers high morbidity and mortality with uncertain…”
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Prediction of the response of colorectal cancer to systemic therapy by Adlard, Julian W, Richman, Susan D, Seymour, Matthew T, Quirke, Phil

“…Adjuvant chemotherapy with fluorouracil and folinic acid improves overall survival for resected carcinoma of the colon of Dukes' stage C by 10-12%. In…”
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A phase I and II study of 2-weekly irinotecan with capecitabine in advanced gastroesophageal adenocarcinoma by BURGE, M. E, SMITH, D, TOPHAM, C, JACKSON, D. P, ANTHONEY, D. A, HALSTEAD, F, SEYMOUR, M. T

“…We investigated 2-weekly intravenous irinotecan combined with oral capecitabine in patients with advanced gastroesophageal adenocarcinoma. In phase I, doses…”
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Oxaliplatin: bimonthly, biweekly, or semimonthly? No, fortnightly by Seymour, Matthew T

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Phase II study of irinotecan with bolus and high dose infusional 5-FU and folinic acid (modified de Gramont) for first or second line treatment of advanced or metastatic colorectal cancer by LEONARD, P, SEYMOUR, M. T, JAMES, R, HOCHHAUSER, D, LEDERMANN, J. A

“…We investigated the activity of irinotecan given with a more convenient modified bimonthly de Gramont regimen of bolus and infusional 5-fluorouracil [IrMdG] in…”
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Phase I and Pharmacokinetic Study of Intravenous Irinotecan Plus Oral Ciclosporin in Patients With Fluorouracil-Refractory Metastatic Colon Cancer by CHESTER, John D, JOEL, Simon P, CHEESEMAN, Susan L, HALL, Geoffrey D, BRAUN, Michael S, PERRY, Jackie, DAVIS, Theresa, BUTTON, Christopher J, SEYMOUR, Matthew T

“…Purpose: To assess the safety and toxicity profile of escalating doses of intravenous irinotecan, in combination with a fixed dose of oral ciclosporin (Cs) and…”
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Lack of pharmacokinetic interaction between 5-fluorouracil and oxaliplatin by Joel, Simon P., Papamichael, Dimitri, Richards, Fiona, Davis, Theresa, Aslanis, Vassili, Chatelut, Etienne, Locke, Kathryn, Slevin, Maurice L., Seymour, Matthew T.

“…Objective Our objective was to investigate the influence of oxaliplatin on the pharmacokinetics of 5‐fluorouracil (5FU) administered in a bolus plus infusional…”
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Protracted infusional 5-fluorouracil (5-FU) with bolus mitomycin in 5-FU-resistant colorectal cancer by Chester, J.D., Dent, J.T., Wilson, G., Ride, E., Seymour, M.T.

“…Background: MF (protracted infusion 5-fluorouracil (5-FU), 300 mg/m2/24 hours plus bolus mitomycin, 7 mg/m2 every 6 weeks, maximum 4 doses), was recently shown…”
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Intravenous Irinotecan Plus Oral Ciclosporin by Vasudev, N.S., Jagdev, S., Anthoney, D.A., Seymour, M.T.

“…We previously reported a phase I study of intravenous irinotecan plus oral ciclosporin, in which dose-limiting diarrhoea was not observed, supporting the…”
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Modified de Gramont with oxaliplatin in the first-line treatment of advanced colorectal cancer by BRAUN, M. S, ADAB, F, MACMILLAN, C, SAUNDERS, M. P, COUNSELL, R, ANDERSON, H, MCDONALD, A, STEWART, J, ROBINSON, A, DAVIES, S, RICHARDS, F. J, SEYMOUR, M. T, BRADLEY, C, MCADAM, K, THOMAS, G, WADD, N. J, REA, D, PHILIPS, R, TWELVES, C, BOZZINO, J

“…We previously reported high activity for oxaliplatin and a modified de Gramont regimen (OxMdG) in a single centre study of patients with metastatic colorectal…”
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Colorectal cancer: treatment of advanced disease by Seymour, M.T.

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Protracted oral etoposide in epithelial ovarian cancer: a phase II study in patients with relapsed or platinum-resistant disease by Seymour, M T, Mansi, J L, Gallagher, C J, Gore, M E, Harper, P G, Evans, T R, Edmonds, P M, Slevin, M L

“…This phase II study evaluates the efficacy and toxicity of a prolonged schedule of oral etoposide in patients with measurable advanced ovarian cancer resistant…”
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Randomized phase II trial of infusional fluorouracil, epirubicin, and cyclophosphamide versus infusional fluorouracil, epirubicin, and cisplatin in patients with advanced breast cancer by Eisen, T, Smith, I E, Johnston, S, Ellis, P A, Prendiville, J, Seymour, M T, Walsh, G, Ashley, S

“…We previously developed an inpatient regimen that consisted of infusional fluorouracil (5-FU), epirubicin, and cisplatin (ECisF), with a response rate of 86%…”
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Epirubicin, cisplatin and oral UFT with leucovorin ('ECU') : A phase I-II study in patients with advanced upper gastrointestinal tract cancer by SEYMOUR, M. T, DENT, J. T, PAPAMICHAEL, D, WILSON, G, CRESSWELL, H, SLEVIN, M. L

“…ECF (epirubicin, cisplatin, protracted venous fluorouracil) is superior to FAMTX in gastroesophageal cancer, but protracted fluorouracil adds to its morbidity…”
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Lack of effect of interferon α2a upon fluorouracil pharmacokinetics by Seymour, MT, Patel, N, Johnston, A, Joel, SP, Slevin, ML

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Ultrasound assessment of residual abnormalities following primary chemotherapy for breast cancer by SEYMOUR, M. T, MOSKOVIC, E. C, WALSH, G, TROTT, P, SMITH, I. E

“…The purpose of this study was to assess the usefulness of ultrasonography (US) in the assessment of the breast following primary medical therapy (PMT) of large…”
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