Search Results - "Seymour, Christopher W"

Time to Treatment and Mortality during Mandated Emergency Care for Sepsis by Seymour, Christopher W, Gesten, Foster, Prescott, Hallie C, Friedrich, Marcus E, Iwashyna, Theodore J, Phillips, Gary S, Lemeshow, Stanley, Osborn, Tiffany, Terry, Kathleen M, Levy, Mitchell M

“…In an analysis including nearly 50,000 patients with sepsis treated at 149 New York hospitals, more rapid delivery of a 3-hour sepsis-care bundle (a protocol…”
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The global burden of sepsis: barriers and potential solutions by Rudd, Kristina E, Kissoon, Niranjan, Limmathurotsakul, Direk, Bory, Sotharith, Mutahunga, Birungi, Seymour, Christopher W, Angus, Derek C, West, T Eoin

“…Sepsis is a major contributor to the global burden of disease. The majority of sepsis cases and deaths are estimated to occur in low and middle-income…”
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Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis by Seymour, Christopher W, Kennedy, Jason N, Wang, Shu, Chang, Chung-Chou H, Elliott, Corrine F, Xu, Zhongying, Berry, Scott, Clermont, Gilles, Cooper, Gregory, Gomez, Hernando, Huang, David T, Kellum, John A, Mi, Qi, Opal, Steven M, Talisa, Victor, van der Poll, Tom, Visweswaran, Shyam, Vodovotz, Yoram, Weiss, Jeremy C, Yealy, Donald M, Yende, Sachin, Angus, Derek C

“…IMPORTANCE: Sepsis is a heterogeneous syndrome. Identification of distinct clinical phenotypes may allow more precise therapy and improve care. OBJECTIVE: To…”
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Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study by Rudd, Kristina E, Johnson, Sarah Charlotte, Agesa, Kareha M, Shackelford, Katya Anne, Tsoi, Derrick, Kievlan, Daniel Rhodes, Colombara, Danny V, Ikuta, Kevin S, Kissoon, Niranjan, Finfer, Simon, Fleischmann-Struzek, Carolin, Machado, Flavia R, Reinhart, Konrad K, Rowan, Kathryn, Seymour, Christopher W, Watson, R Scott, West, T Eoin, Marinho, Fatima, Hay, Simon I, Lozano, Rafael, Lopez, Alan D, Angus, Derek C, Murray, Christopher J L, Naghavi, Mohsen

“…Sepsis is life-threatening organ dysfunction due to a dysregulated host response to infection. It is considered a major cause of health loss, but data for the…”
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Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014 by Rhee, Chanu, Dantes, Raymund, Epstein, Lauren, Murphy, David J, Seymour, Christopher W, Iwashyna, Theodore J, Kadri, Sameer S, Angus, Derek C, Danner, Robert L, Fiore, Anthony E, Jernigan, John A, Martin, Greg S, Septimus, Edward, Warren, David K, Karcz, Anita, Chan, Christina, Menchaca, John T, Wang, Rui, Gruber, Susan, Klompas, Michael

“…IMPORTANCE: Estimates from claims-based analyses suggest that the incidence of sepsis is increasing and mortality rates from sepsis are decreasing. However,…”
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Association Between the New York Sepsis Care Mandate and In-Hospital Mortality for Pediatric Sepsis by Evans, Idris V. R, Phillips, Gary S, Alpern, Elizabeth R, Angus, Derek C, Friedrich, Marcus E, Kissoon, Niranjan, Lemeshow, Stanley, Levy, Mitchell M, Parker, Margaret M, Terry, Kathleen M, Watson, R. Scott, Weiss, Scott L, Zimmerman, Jerry, Seymour, Christopher W

“…IMPORTANCE: The death of a pediatric patient with sepsis motivated New York to mandate statewide sepsis treatment in 2013. The mandate included a 1-hour bundle…”
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Precision medicine for all? Challenges and opportunities for a precision medicine approach to critical illness by Seymour, Christopher W, Gomez, Hernando, Chang, Chung-Chou H, Clermont, Gilles, Kellum, John A, Kennedy, Jason, Yende, Sachin, Angus, Derek C

“…All of medicine aspires to be precise, where a greater understanding of individual data will lead to personalized treatment and improved outcomes. Prompted by…”
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Critical care bed growth in the United States. A comparison of regional and national trends by Wallace, David J, Angus, Derek C, Seymour, Christopher W, Barnato, Amber E, Kahn, Jeremy M

“…Although the number of intensive care unit (ICU) beds in the United States is increasing, it is unknown whether this trend is consistent across all regions. We…”
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Comparing the validity of different ICD coding abstraction strategies for sepsis case identification in German claims data by Fleischmann-Struzek, Carolin, Thomas-Rüddel, Daniel O, Schettler, Anna, Schwarzkopf, Daniel, Stacke, Angelika, Seymour, Christopher W, Haas, Christoph, Dennler, Ulf, Reinhart, Konrad

“…Administrative data are used to generate estimates of sepsis epidemiology and can serve as source for quality indicators. Aim was to compare estimates on…”
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COVID-19 Infection—Preventing Clinical Deterioration by Seymour, Christopher W, Bauchner, Howard, Golub, Robert M

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Time to treatment and mortality for clinical sepsis subtypes by Yang, Anne, Kennedy, Jason N, Reitz, Katherine M, Phillips, Gary, Terry, Kathleen M, Levy, Mitchell M, Angus, Derek C, Seymour, Christopher W

“…Sepsis is common, deadly, and heterogenous. Prior analyses of patients with sepsis and septic shock in New York State showed a risk-adjusted association…”
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A manifesto for the future of ICU trials by Goligher, Ewan C, Zampieri, Fernando, Calfee, Carolyn S, Seymour, Christopher W

“…1 Think Bayesian Bayesian analysis is an alternate statistical paradigm that answers the question “what is the probability of treatment effect” in contrast to…”
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Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care. NHLBI Working Group Report by Semler, Matthew W, Bernard, Gordon R, Aaron, Shawn D, Angus, Derek C, Biros, Michelle H, Brower, Roy G, Calfee, Carolyn S, Colantuoni, Elizabeth A, Ferguson, Niall D, Gong, Michelle N, Hopkins, Ramona O, Hough, Catherine L, Iwashyna, Theodore J, Levy, Bruce D, Martin, Thomas R, Matthay, Michael A, Mizgerd, Joseph P, Moss, Marc, Needham, Dale M, Self, Wesley H, Seymour, Christopher W, Stapleton, Renee D, Thompson, B Taylor, Wunderink, Richard G, Aggarwal, Neil R, Reineck, Lora A

“…Preventing, treating, and promoting recovery from critical illness due to pulmonary disease are foundational goals of the critical care community and the…”
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Variation in Identifying Sepsis and Organ Dysfunction Using Administrative Versus Electronic Clinical Data and Impact on Hospital Outcome Comparisons by Rhee, Chanu, Jentzsch, Maximilian S., Kadri, Sameer S., Seymour, Christopher W., Angus, Derek C., Murphy, David J., Martin, Greg S., Dantes, Raymund B., Epstein, Lauren, Fiore, Anthony E., Jernigan, John A., Danner, Robert L., Warren, David K., Septimus, Edward J., Hickok, Jason, Poland, Russell E., Jin, Robert, Fram, David, Schaaf, Richard, Wang, Rui, Klompas, Michael

“…OBJECTIVES:Administrative claims data are commonly used for sepsis surveillance, research, and quality improvement. However, variations in diagnosis,…”
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Arguing for Adaptive Clinical Trials in Sepsis by Talisa, Victor B, Yende, Sachin, Seymour, Christopher W, Angus, Derek C

“…Sepsis is life-threatening organ dysfunction due to dysregulated response to infection. Patients with sepsis exhibit wide heterogeneity stemming from genetic,…”
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Identification of a hyperinflammatory sepsis phenotype using protein biomarker and clinical data in the ProCESS randomized trial by DeMerle, Kimberley M., Kennedy, Jason N., Chang, Chung-Chou H., Delucchi, Kevin, Huang, David T., Kravitz, Max S., Shapiro, Nathan I., Yealy, Donald M., Angus, Derek C., Calfee, Carolyn S., Seymour, Christopher W.

“…Sepsis is a heterogeneous syndrome and phenotypes have been proposed using clinical data. Less is known about the contribution of protein biomarkers to…”
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Circulating hypoxia-dependent miR-210 is increased in clinical sepsis subtypes: A cohort study by Powell, Rachel E, Tai, Yi Yin, Kennedy, Jason N, Seymour, Christopher W, Chan, Stephen Y

“…Because ischemic end-organ damage and endothelial dysfunction may contribute to differences in sepsis [2], we hypothesize that treatment-response subtypes may…”
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Hospital-Level Variation in ICU Admission and Critical Care Procedures for Patients Hospitalized for Pulmonary Embolism by Admon, Andrew J., MD, MPH, Seymour, Christopher W., MD, Gershengorn, Hayley B., MD, Wunsch, Hannah, MD, Cooke, Colin R., MD

“…Abstract BACKGROUND: Variation in the use of ICUs for low-risk conditions contributes to health system inefficiency. We sought to examine the relationship…”
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The Burden of Influenza-Associated Critical Illness Hospitalizations by Ortiz, Justin R, Neuzil, Kathleen M, Shay, David K, Rue, Tessa C, Neradilek, Moni B, Zhou, Hong, Seymour, Christopher W, Hooper, Laura G, Cheng, Po-Yung, Goss, Christopher H, Cooke, Colin R

“…OBJECTIVE:Influenza is the most common vaccine-preventable disease in the United States; however, little is known about the burden of critical illness due to…”
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Murine sepsis phenotypes and differential treatment effects in a randomized trial of prompt antibiotics and fluids by Seymour, Christopher W, Kerti, Samantha J, Lewis, Anthony J, Kennedy, Jason, Brant, Emily, Griepentrog, John E, Zhang, Xianghong, Angus, Derek C, Chang, Chung-Chou H, Rosengart, Matthew R

“…Clinical and biologic phenotypes of sepsis are proposed in human studies, yet it is unknown whether prognostic or drug response phenotypes are present in…”
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