Search Results - "Seyfried, T N"

Ketone supplementation decreases tumor cell viability and prolongs survival of mice with metastatic cancer by Poff, A.M., Ari, C., Arnold, P., Seyfried, T.N., D'Agostino, D.P.

“…Cancer cells express an abnormal metabolism characterized by increased glucose consumption owing to genetic mutations and mitochondrial dysfunction. Previous…”
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Non-Toxic Metabolic Management of Metastatic Cancer in VM Mice: Novel Combination of Ketogenic Diet, Ketone Supplementation, and Hyperbaric Oxygen Therapy by Poff, A M, Ward, N, Seyfried, T N, Arnold, P, D'Agostino, D P

“…The Warburg effect and tumor hypoxia underlie a unique cancer metabolic phenotype characterized by glucose dependency and aerobic fermentation. We previously…”
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Alpha-2 macroglobulin in Alzheimer’s disease: a marker of neuronal injury through the RCAN1 pathway by Varma, V R, Varma, S, An, Y, Hohman, T J, Seddighi, S, Casanova, R, Beri, A, Dammer, E B, Seyfried, N T, Pletnikova, O, Moghekar, A, Wilson, M R, Lah, J J, O'Brien, R J, Levey, A I, Troncoso, J C, Albert, M S, Thambisetty, M

“…Preclinical changes that precede the onset of symptoms and eventual diagnosis of Alzheimer’s disease (AD) are a target for potential preventive interventions…”
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Sex-Related Abnormalities in Substantia Nigra Lipids in Parkinson’s Disease by Seyfried, T. N., Choi, H., Chevalier, A., Hogan, D., Akgoc, Z., Schneider, J. S.

“…Parkinson’s disease (PD) is a neurodegenerative movement disorder involving the selective loss of dopamine-producing neurons in the substantia nigra (SN)…”
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Role of glucose and ketone bodies in the metabolic control of experimental brain cancer by SEYFRIED, T. N, SANDERSON, T. M, EL-ABBADI, M. M, MCGOWAN, R, MUKHERJEE, P

“…Brain tumours lack metabolic versatility and are dependent largely on glucose for energy. This contrasts with normal brain tissue that can derive energy from…”
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Complete Correction of Enzymatic Deficiency and Neurochemistry in the GM1-gangliosidosis Mouse Brain by Neonatal Adeno-associated Virus–mediated Gene Delivery by Broekman, M L D, Baek, R C, Comer, L A, Fernandez, J L, Seyfried, T N, Sena-Esteves, M

“…GM1-gangliosidosis is a glycosphingolipid (GSL) lysosomal storage disease caused by autosomal recessive deficiency of lysosomal acid β-galactosidase (βgal),…”
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Substrate reduction reduces gangliosides in postnatal cerebrum-brainstem and cerebellum in GM1 gangliosidosis mice by Kasperzyk, J.L., d'Azzo, A., Platt, F.M., Alroy, J., Seyfried, T.N.

“…II3NeuAc-GgOse4Cer (GM1) gangliosidosis is an incurable lysosomal storage disease caused by a deficiency in acid β-galactosidase (β-gal), resulting in the…”
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Cancer as a metabolic disease: implications for novel therapeutics by Seyfried, Thomas N, Flores, Roberto E, Poff, Angela M, D'Agostino, Dominic P

“…Emerging evidence indicates that cancer is primarily a metabolic disease involving disturbances in energy production through respiration and fermentation. The…”
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Expression of cyclooxygenase 2 (COX-2) in human glioma and in vitro inhibition by a specific COX-2 inhibitor, NS-398 by JOKI, Tatsuhiro, HEESE, Oliver, BLACK, Peter M, NIKAS, Demetrios C, BELLO, Lorenzo, JIANPING ZHANG, KRAEFT, Stine-Kathrein, SEYFRIED, Nicholas T, ABE, Toshiaki, LAN BO CHEN, CARROLL, Rona S

“…The up-regulation of cyclooxygenase 2 (COX-2) expression is a frequent occurrence in a variety of different tumors. In this study, COX-2 protein expression was…”
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Dietary restriction reduces angiogenesis and growth in an orthotopic mouse brain tumour model by MUKHERJEE, P, EL-ABBADI, M. M, KASPERZYK, J. L, RANES, M. K, SEYFRIED, T. N

“…Diet and lifestyle produce major effects on tumour incidence, prevalence, and natural history. Moderate dietary restriction has long been recognised as a…”
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The Ketogenic Diet Inhibits Epileptogenesis in EL Mice: A Genetic Model for Idiopathic Epilepsy by Todorova, M. T., Tandon, P., Madore, R. A., Stafstrom, C. E., Seyfried, T. N.

“…Purpose: The ketogenic diet (KD) is a high‐fat, low‐carbohydrate and ‐protein diet that has been used to treat refractory seizures in children for more than 75…”
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FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage by Deng, Qiudong, Holler, Christopher J, Taylor, Georgia, Hudson, Kathryn F, Watkins, William, Gearing, Marla, Ito, Daisuke, Murray, Melissa E, Dickson, Dennis W, Seyfried, Nicholas T, Kukar, Thomas

“…Abnormal cytoplasmic accumulation of Fused in Sarcoma (FUS) in neurons defines subtypes of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar…”
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An interim exploratory proteomics biomarker analysis of a phase 2 clinical trial to assess the impact of CT1812 in Alzheimer's disease by Lizama, B.N., North, H.A., Pandey, K., Williams, C., Duong, D., Cho, E., Di Caro, V., Ping, L., Blennow, K., Zetterberg, H., Lah, J., Levey, A.I., Grundman, M., Caggiano, A.O., Seyfried, N.T., Hamby, M.E.

“…CT1812 is a novel, brain penetrant small molecule modulator of the sigma-2 receptor (S2R) that is currently in clinical development for the treatment of…”
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RGS14 limits seizure-induced mitochondrial oxidative stress and pathology in hippocampus by Harbin, N.H., Lustberg, D.J., Hurst, C., Pare, J., Crotty, K.M., Waters, A.L., Yeligar, S.M., Smith, Y., Seyfried, N.T., Weinshenker, D., Hepler, J.R.

“…RGS14 is a complex multifunctional scaffolding protein that is highly enriched within pyramidal cells (PCs) of hippocampal area CA2. In these neurons, RGS14…”
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N-butyldeoxynojirimycin reduces growth and ganglioside content of experimental mouse brain tumours by RANES, M. K, EL-ABBADI, M, MANFREDI, M. G, MUKHERJEE, P, PLATT, F. M, SEYFRIED, T. N

“…Abnormalities in glycosphingolipid (GSL) biosynthesis have been implicated in the oncogenesis and malignancy of brain tumours. GSLs comprise the gangliosides…”
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Widespread correction of central nervous system disease after intracranial gene therapy in a feline model of Sandhoff disease by McCurdy, V J, Rockwell, H E, Arthur, J R, Bradbury, A M, Johnson, A K, Randle, A N, Brunson, B L, Hwang, M, Gray-Edwards, H L, Morrison, N E, Johnson, J A, Baker, H J, Cox, N R, Seyfried, T N, Sena-Esteves, M, Martin, D R

“…Sandhoff disease (SD) is caused by deficiency of N-acetyl-β-hexosaminidase (Hex) resulting in pathological accumulation of GM2 ganglioside in lysosomes of the…”
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Genetic and environmental interactions determine seizure susceptibility in epileptic EL mice by Todorova, M. T., Mantis, J. G., Le, M., Kim, C. Y., Seyfried, T. N.

“…Gene identification has progressed rapidly for monogenic epilepsies, but complex gene–environmental interactions have hindered progress in gene identification…”
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Tissue-type plasminogen activator regulates the neuronal uptake of glucose in the ischemic brain by Wu, Fang, Wu, Jialing, Nicholson, Andrew D, Echeverry, Ramiro, Haile, Woldeab B, Catano, Marcela, An, Jie, Lee, Andrew K, Duong, Duc, Dammer, Eric B, Seyfried, Nicholas T, Tong, Frank C, Votaw, John R, Medcalf, Robert L, Yepes, Manuel

“…The ability to sense and adapt to hypoxic conditions plays a pivotal role in neuronal survival. Hypoxia induces the release of tissue-type plasminogen…”
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Stimulation-dependent release of adenosine triphosphate from hippocampal slices by Wieraszko, A, Goldsmith, G, Seyfried, T N

“…Schaffer collaterals of rat and mouse hippocampal slices were stimulated with bursts of pulses (300 Hz for 50 ms, 2-s intervals) for 30-s which caused a stable…”
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Ganglioside composition and histology of a spontaneous metastatic brain tumour in the VM mouse by EL-ABBADI, M, SEYFRIED, T. N, YATES, A. J, OROSZ, C, LEE, M. C

“…Glycosphingolipid abnormalities have long been implicated in tumour malignancy and metastasis. Gangliosides are a family of sialic acid-containing…”
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