Search Results - "Seyfert, Carsten E."

Thermo-amplifier circuit in probiotic E. coli for stringently temperature-controlled release of a novel antibiotic by Dey, Sourik, Seyfert, Carsten E., Fink-Straube, Claudia, Kany, Andreas M., Müller, Rolf, Sankaran, Shrikrishnan

“…Peptide drugs have seen rapid advancement in biopharmaceutical development, with over 80 candidates approved globally. Despite their therapeutic potential, the…”
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Improved broad-spectrum antibiotics against Gram-negative pathogens via darobactin biosynthetic pathway engineering by Groß, Sebastian, Panter, Fabian, Pogorevc, Domen, Seyfert, Carsten E., Deckarm, Selina, Bader, Chantal D., Herrmann, Jennifer, Müller, Rolf

“…The development of new antibiotics is imperative to fight increasing mortality rates connected to infections caused by multidrug-resistant (MDR) bacteria. In…”
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Darobactins Exhibiting Superior Antibiotic Activity by Cryo‐EM Structure Guided Biosynthetic Engineering by Seyfert, Carsten E., Porten, Christoph, Yuan, Biao, Deckarm, Selina, Panter, Fabian, Bader, Chantal D., Coetzee, Janetta, Deschner, Felix, Tehrani, Kamaleddin H. M. E., Higgins, Paul G., Seifert, Harald, Marlovits, Thomas C., Herrmann, Jennifer, Müller, Rolf

“…Over recent decades, the pipeline of antibiotics acting against Gram‐negative bacteria is running dry, as most discovered candidate antibiotics suffer from…”
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Investigation of the Odilorhabdin Biosynthetic Gene Cluster Using NRPS Engineering by Präve, Leonard, Seyfert, Carsten E., Bozhüyük, Kenan A. J., Racine, Emilie, Müller, Rolf, Bode, Helge B.

“…The recently identified natural product NOSO‐95A from entomopathogenic Xenorhabdus bacteria, derived from a biosynthetic gene cluster (BGC) encoding a…”
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New Genetically Engineered Derivatives of Antibacterial Darobactins Underpin Their Potential for Antibiotic Development by Seyfert, Carsten E., Müller, Alison V., Walsh, Danica J., Birkelbach, Joy, Kany, Andreas M., Porten, Christoph, Yuan, Biao, Krug, Daniel, Herrmann, Jennifer, Marlovits, Thomas C., Hirsch, Anna K. H., Müller, Rolf

“…Biosynthetic engineering of bicyclic darobactins, selectively sealing the lateral gate of the outer membrane protein BamA, leads to active analogues, which are…”
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Harnessing Gram‐negative bacteria for novel anti‐Gram‐negative antibiotics by Birkelbach, Joy, Seyfert, Carsten E., Walesch, Sebastian, Müller, Rolf

“…Natural products have proven themselves as a valuable resource for antibiotics. However, in view of increasing antimicrobial resistance, there is an urgent…”
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Investigation of the Odilorhabdin Biosynthetic Gene Cluster Using NRPS Engineering by Präve, Leonard, Seyfert, Carsten E., Bozhüyük, Kenan A. J., Racine, Emilie, Müller, Rolf, Bode, Helge B.

“…The recently identified natural product NOSO‐95A from entomopathogenic Xenorhabdus bacteria, derived from a biosynthetic gene cluster (BGC) encoding a…”
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In Vivo Activity Profiling of Biosynthetic Darobactin D22 against Critical Gram-Negative Pathogens by Kany, Andreas M., Fries, Franziska, Seyfert, Carsten E., Porten, Christoph, Deckarm, Selina, Chacón Ortiz, María, Dubarry, Nelly, Vaddi, Swapna, Große, Miriam, Bernecker, Steffen, Sandargo, Birthe, Müller, Alison V., Bacqué, Eric, Stadler, Marc, Herrmann, Jennifer, Müller, Rolf

“…In recent years, naturally occurring darobactins have emerged as a promising compound class to combat infections caused by critical Gram-negative pathogens. In…”
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Darobactine: eine neue Antibiotikaklasse in Entwicklung by Seyfert, Carsten E., Porten, Christoph, Müller, Rolf

“…The discovery pipeline for novel antibiotics runs dry, while antimicrobial resistances increase, causing 1.3 million deaths per year globally. Even in the…”
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Innentitelbild: Darobactine mit Überlegener Antibiotischer Aktivität Generiert durch Strukturgeleitetes Kryo‐EM‐Biosynthese‐Design (Angew. Chem. 2/2023) by Seyfert, Carsten E., Porten, Christoph, Yuan, Biao, Deckarm, Selina, Panter, Fabian, Bader, Chantal D., Coetzee, Janetta, Deschner, Felix, Tehrani, Kamaleddin H. M. E., Higgins, Paul G., Seifert, Harald, Marlovits, Thomas C., Herrmann, Jennifer, Müller, Rolf

“…Darobactins bind to the novel antibiotic target BamA in the outer membrane BAM‐complex of Gram‐negative pathogens. The renewal of the outer membrane proteins…”
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Darobactine mit Überlegener Antibiotischer Aktivität Generiert durch Strukturgeleitetes Kryo‐EM‐Biosynthese‐Design by Seyfert, Carsten E., Porten, Christoph, Yuan, Biao, Deckarm, Selina, Panter, Fabian, Bader, Chantal D., Coetzee, Janetta, Deschner, Felix, Tehrani, Kamaleddin H. M. E., Higgins, Paul G., Seifert, Harald, Marlovits, Thomas C., Herrmann, Jennifer, Müller, Rolf

“…In den letzten Jahrzehnten ist die Entwicklungspipeline neuer Antibiotika gegen Gram‐negative Bakterien nahezu zum Erliegen gekommen, da die meisten entdeckten…”
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Darobactine: eine neue Antibiotikaklasse in Entwicklung by Seyfert, Carsten E., Porten, Christoph, Müller, Rolf

“…The discovery pipeline for novel antibiotics runs dry, while antimicrobial resistances increase, causing 1.3 million deaths per year globally. Even in the…”
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Inside Cover: Darobactins Exhibiting Superior Antibiotic Activity by Cryo‐EM Structure Guided Biosynthetic Engineering (Angew. Chem. Int. Ed. 2/2023) by Seyfert, Carsten E., Porten, Christoph, Yuan, Biao, Deckarm, Selina, Panter, Fabian, Bader, Chantal D., Coetzee, Janetta, Deschner, Felix, Tehrani, Kamaleddin H. M. E., Higgins, Paul G., Seifert, Harald, Marlovits, Thomas C., Herrmann, Jennifer, Müller, Rolf

“…Darobactins bind to the novel antibiotic target BamA in the outer membrane BAM‐complex of Gram‐negative pathogens. The renewal of the outer membrane proteins…”
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Improved broad-spectrum antibiotics against Gram-negative pathogens darobactin biosynthetic pathway engineering by Groß, Sebastian, Panter, Fabian, Pogorevc, Domen, Seyfert, Carsten E, Deckarm, Selina, Bader, Chantal D, Herrmann, Jennifer, Müller, Rolf

“…The development of new antibiotics is imperative to fight increasing mortality rates connected to infections caused by multidrug-resistant (MDR) bacteria. In…”
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