Search Results - "Seyen, Sandrine"

Dominant-Negative Control of cAMP-Dependent IKs Upregulation in Human Long-QT Syndrome Type 1 by Heijman, Jordi, Spätjens, Roel L.H.M.G, Seyen, Sandrine R.M, Lentink, Viola, Kuijpers, Helma J.H, Boulet, Inge R, de Windt, Leon J, David, Miren, Volders, Paul G.A

“…RATIONALE:The mutation A341V in the S6 transmembrane segment of KCNQ1, the α-subunit of the slowly activating delayed-rectifier K (IKs) channel, predisposes to…”
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Mutation location and I  Ks regulation in the arrhythmic risk of long QT syndrome type 1: the importance of the KCNQ1 S6 region by Schwartz, Peter J, Moreno, Cristina, Kotta, Maria-Christina, Pedrazzini, Matteo, Crotti, Lia, Dagradi, Federica, Castelletti, Silvia, Haugaa, Kristina H, Denjoy, Isabelle, Shkolnikova, Maria A, Brink, Paul A, Heradien, Marshall J, Seyen, Sandrine R M, Spätjens, Roel L H M G, Spazzolini, Carla, Volders, Paul G A

“…Abstract Aims Mutation type, location, dominant-negative I  Ks reduction, and possibly loss of cyclic adenosine monophosphate (cAMP)-dependent I  Ks…”
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Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure by Dirkx, Ellen, Gladka, Monika M., Philippen, Leonne E., Armand, Anne-Sophie, Kinet, Virginie, Leptidis, Stefanos, el Azzouzi, Hamid, Salic, Kanita, Bourajjaj, Meriem, da Silva, Gustavo J. J., Olieslagers, Servé, van der Nagel, Roel, de Weger, Roel, Bitsch, Nicole, Kisters, Natasja, Seyen, Sandrine, Morikawa, Yuka, Chanoine, Christophe, Heymans, Stephane, Volders, Paul G. A., Thum, Thomas, Dimmeler, Stefanie, Cserjesi, Peter, Eschenhagen, Thomas, da Costa Martins, Paula A., De Windt, Leon J.

“…Although aberrant reactivation of embryonic gene programs is intricately linked to pathological heart disease, the transcription factors driving these gene…”
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Dominant-Negative Control of cAMP-Dependent I Ks Upregulation in Human Long-QT Syndrome Type 1 by Heijman, Jordi, Spätjens, Roel L.H.M.G., Seyen, Sandrine R.M., Lentink, Viola, Kuijpers, Helma J.H., Boulet, Inge R., de Windt, Leon J., David, Miren, Volders, Paul G.A.

“…Rationale: The mutation A341V in the S6 transmembrane segment of KCNQ1 , the α-subunit of the slowly activating delayed-rectifier K + (I Ks ) channel,…”
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The usefulness of operant conditioning procedures to assess long-lasting deficits following transient focal ischemia in mice by Ferrara, André, El Bejaoui, Sophie, Seyen, Sandrine, Tirelli, Ezio, Plumier, Jean-Christophe

“…In this study, we examined a number of short and long-term sensorimotor, behavioural and cognitive consequences of an experimental ischemia induced by a 60-min…”
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Long-QT mutation p.K557E-Kv7.1: dominant-negative suppression of IKs, but preserved cAMP-dependent up-regulation by Spätjens, Roel L.H.M.G., Bébarová, Markéta, Seyen, Sandrine R.M., Lentink, Viola, Jongbloed, Roselie J., Arens, Yvonne H.J.M., Heijman, Jordi, Volders, Paul G.A.

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Restoring Defective Camp-Dependent Upregulation in Long-QT Syndrome Type-1 through Interventions that Promote IKs Channel Opening by Moreno Vadillo, Cristina, Spätjens, Roel L.H.M.G., Seyen, Sandrine, Menini, Gabriele, Heijman, Jordi, Volders, Paul

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Restoring Defective Camp-Dependent Upregulation in Long-QT Syndrome Type-1 through Interventions that Promote I Ks Channel Opening by Moreno Vadillo, Cristina, Spätjens, Roel L.H.M.G., Seyen, Sandrine, Menini, Gabriele, Heijman, Jordi, Volders, Paul

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INA Loss-of-Function by Compound Variants in SCN5A from a Large Founder Population with Excess Sudden Cardiac Death by Altrocchi, Cristina, Spätjens, Roel R.L., Sutanto, Henry, ter Bekke, Rachel M.A., Seyen, Sandrine, Heijman, Jordi, Moreno, Cristina, Volders, Paul G.A.

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Mutation location and IKs regulation in the arrhythmic risk of long QT syndrome type 1: the importance of the KCNQ1 S6 region by Schwartz, Peter J, Moreno, Cristina, Kotta, Maria-Christina, Pedrazzini, Matteo, Crotti, Lia, Dagradi, Federica, Castelletti, Silvia, Haugaa, Kristina H, Denjoy, Isabelle, Shkolnikova, Maria A, Brink, Paul A, Heradien, Marshall J, Seyen, Sandrine R M, Spätjens, Roel L H M G, Spazzolini, Carla, Volders, Paul G A

“…Abstract Aims Mutation type, location, dominant-negative IKs reduction, and possibly loss of cyclic adenosine monophosphate (cAMP)-dependent IKs stimulation…”
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Abstract 242: Priming for Action: Interventions That Promote IKs-Channel Opening Restore Defective cAMP-Dependent Upregulation in Long-QT1 Syndrome by Volders, Paul G, Spätjens, Roel L, Seyen, Sandrine R, Menini, Gabriele, Moreno Vadillo, Cristina

“…Abstract only Introduction: Patients with the KCNQ1 mutation A341V show a high incidence of sympathetically-triggered ventricular tachyarrhythmias and sudden…”
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Benfotiamine, a synthetic S-acyl thiamine derivative, has different mechanisms of action and a different pharmacological profile than lipid-soluble thiamine disulfide derivatives by Volvert, Marie-Laure, Seyen, Sandrine, Piette, Marie, Evrard, Brigitte, Gangolf, Marjorie, Plumier, Jean-Christophe, Bettendorff, Lucien

“…Lipid-soluble thiamine precursors have a much higher bioavailability than genuine thiamine and therefore are more suitable for therapeutic purposes…”
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Long-QT mutation p.K557E-Kv7.1: dominant-negative suppression of IKs, but preserved cAMP-dependent up-regulation by Spätjens, Roel L H M G, Bébarová, Markéta, Seyen, Sandrine R M, Lentink, Viola, Jongbloed, Roselie J, Arens, Yvonne H J M, Heijman, Jordi, Volders, Paul G A

“…Mutations in KCNQ1, encoding for Kv7.1, the α-subunit of the IKs channel, cause long-QT syndrome type 1, potentially predisposing patients to ventricular…”
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