Search Results - "Seyedi, Nahid"
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Interaction between sensory C-fibers and cardiac mast cells in ischemia/reperfusion: activation of a local renin-angiotensin system culminating in severe arrhythmic dysfunction
Published in The Journal of pharmacology and experimental therapeutics (01-10-2010)“…Renin, the rate-limiting enzyme in the activation of the renin-angiotensin system (RAS), is synthesized and stored in cardiac mast cells. In…”
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Histamine H3-receptor signaling in cardiac sympathetic nerves: Identification of a novel MAPK-PLA2-COX-PGE2-EP3R pathway
Published in Biochemical pharmacology (15-04-2007)“…We hypothesized that the histamine H(3)-receptor (H(3)R)-mediated attenuation of norepinephrine (NE) exocytosis from cardiac sympathetic nerves results not…”
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Chronic Exercise in Dogs Increases Coronary Vascular Nitric Oxide Production and Endothelial Cell Nitric Oxide Synthase Gene Expression
Published in Circulation research (01-02-1994)“…Recently, we have shown that chronic exercise increases endothelium-derived relaxing factor (EDRF)/nitric oxide (NO)-mediated epicardial coronary artery…”
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Histamine H3-receptor-induced attenuation of norepinephrine exocytosis: a decreased protein kinase a activity mediates a reduction in intracellular calcium
Published in The Journal of pharmacology and experimental therapeutics (01-01-2005)“…We had reported that activation of presynaptic histamine H(3)-receptors inhibits norepinephrine exocytosis from depolarized cardiac sympathetic nerve endings,…”
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Decreased Intracellular Calcium Mediates the Histamine H3-Receptor-Induced Attenuation of Norepinephrine Exocytosis from Cardiac Sympathetic Nerve Endings
Published in Proceedings of the National Academy of Sciences - PNAS (08-01-2002)“…Activation of presynatic histamine H3 receptors (H3R) down-regulates norepinephrine exocytosis from cardiac sympathetic nerve terminals, in both normal and…”
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Coronary Kinin Generation Mediates Nitric Oxide Release After Angiotensin Receptor Stimulation
Published in Hypertension (Dallas, Tex. 1979) (01-07-1995)“…Our goal was to determine whether angiotensin II (Ang II) and its metabolic fragments release nitric oxide and the mechanisms by which this occurs in blood…”
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Bradykinin activates a cross-signaling pathway between sensory and adrenergic nerve endings in the heart: a novel mechanism of ischemic norepinephrine release?
Published in The Journal of pharmacology and experimental therapeutics (01-08-1999)“…We had shown that bradykinin (BK) generated by cardiac sympathetic nerve endings (i.e., synaptosomes) promotes exocytotic norepinephrine (NE) release in an…”
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Norepinephrine release from the ischemic heart is greatly enhanced in mice lacking histamine H3 receptors
Published in Molecular pharmacology (01-02-2003)“…We previously reported that histamine H(3) receptors (H(3)Rs) are present in cardiac sympathetic nerve endings (cSNE) of animals and humans, where they…”
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Pharmacodynamics of plasma nitrate/nitrite as an indication of nitric oxide formation in conscious dogs
Published in Circulation (New York, N.Y.) (15-06-1995)“…The present investigation was undertaken to better understand the production of nitric oxide (NO) in vivo as measured by alterations in plasma nitrite or…”
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Regulation of nitric oxide production in human coronary microvessels and the contribution of local kinin formation
Published in Circulation (New York, N.Y.) (01-07-1996)“…The goal of this study was to define the regulation of nitric oxide release by coronary microvessels from the failing and nonfailing human heart and to…”
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Ischemia promotes renin activation and angiotensin formation in sympathetic nerve terminals isolated from the human heart: contribution to carrier-mediated norepinephrine release
Published in The Journal of pharmacology and experimental therapeutics (01-08-2002)“…We recently reported that in the ischemic human heart, locally formed angiotensin II activates angiotensin II type 1 (AT(1)) receptors on sympathetic nerve…”
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An Unsuspected Property of Natriuretic Peptides: Promotion of Calcium-Dependent Catecholamine Release Via Protein Kinase G-Mediated Phosphodiesterase Type 3 Inhibition
Published in Circulation (New York, N.Y.) (17-01-2012)“…Although natriuretic peptides are considered cardioprotective, clinical heart failure trials with recombinant brain natriuretic peptide (nesiritide) failed to…”
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Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion
Published in The Journal of clinical investigation (01-04-2006)“…Having identified renin in cardiac mast cells, we assessed whether its release leads to cardiac dysfunction. In Langendorff-perfused guinea pig hearts, mast…”
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Aldehyde dehydrogenase type 2 activation by adenosine and histamine inhibits ischemic norepinephrine release in cardiac sympathetic neurons: mediation by protein kinase Cε
Published in The Journal of pharmacology and experimental therapeutics (01-10-2012)“…During myocardial ischemia/reperfusion, lipid peroxidation leads to the formation of toxic aldehydes that contribute to ischemic dysfunction. Mitochondrial…”
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Proadrenergic effects of cardiac natriuretic peptides: inhibition by histamine H3‐receptor (H3R) activation
Published in The FASEB journal (01-04-2011)“…Natriuretic peptides (NP) are generally viewed as cardioprotective. Yet, NP were recently found to increase myocardial infarct size in mice, while their…”
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A novel proadrenergic effect of cardiac natriuretic peptides: inhibition by histamine H3‐receptor activation
Published in The FASEB journal (01-04-2010)“…Natriuretic peptides (NP) are generally viewed as cardioprotective. Yet, NP were recently found to increase myocardial infarct size in mice, while their…”
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Decreased intracellular calcium mediates the histamine H 3 -receptor-induced attenuation of norepinephrine exocytosis from cardiac sympathetic nerve endings
Published in Proceedings of the National Academy of Sciences - PNAS (08-01-2002)“…Activation of presynatic histamine H 3 receptors (H 3 R) down-regulates norepinephrine exocytosis from cardiac sympathetic nerve terminals, in both normal and…”
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Bradykinin B 2 -Receptor Activation Augments Norepinephrine Exocytosis From Cardiac Sympathetic Nerve Endings: Mediation by Autocrine/Paracrine Mechanisms
Published in Circulation research (01-11-1997)“…Abstract We determined whether local bradykinin production modulates cardiac adrenergic activity. Depolarization of guinea pig heart sympathetic nerve endings…”
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Histamine H 3-receptor signaling in cardiac sympathetic nerves: Identification of a novel MAPK-PLA 2-COX-PGE 2-EP 3R pathway
Published in Biochemical pharmacology (2007)“…We hypothesized that the histamine H 3-receptor (H 3R)-mediated attenuation of norepinephrine (NE) exocytosis from cardiac sympathetic nerves results not only…”
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