Search Results - "Seydel, Karl B"
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School-Age Children Are a Reservoir of Malaria Infection in Malawi
Published in PloS one (24-07-2015)“…Malaria surveillance and interventions in endemic countries often target young children at highest risk of malaria morbidity and mortality. We aimed to…”
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Cerebral malaria is associated with differential cytoadherence to brain endothelial cells
Published in EMBO molecular medicine (01-02-2019)“…Sequestration of Plasmodium falciparum ‐infected erythrocytes (IE) within the brain microvasculature is a hallmark of cerebral malaria (CM). Using a…”
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Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children
Published in Blood (01-08-2013)“…Cerebral malaria (CM) is a major cause of mortality in African children and the mechanisms underlying its development, namely how malaria-infected erythrocytes…”
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Aggressive antipyretics in central nervous system malaria: Study protocol of a randomized-controlled trial assessing antipyretic efficacy and parasite clearance effects (Malaria FEVER study)
Published in PloS one (07-10-2022)“…Malaria remains a major public health challenge in Africa where annually, ~250,000 children with malaria experience a neurologic injury with subsequent…”
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Protocol for a magnetic resonance imaging study of participants in the fever RCT: Does fever control prevent brain injury in malaria?
Published in PloS one (19-04-2024)“…Despite eradication efforts, ~135,000 African children sustained brain injuries as a result of central nervous system (CNS) malaria in 2021. Newer antimalarial…”
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The ability of Interleukin-10 to negate haemozoin-related pro-inflammatory effects has the potential to restore impaired macrophage function associated with malaria infection
Published in Malaria journal (14-04-2023)“…Although pro-inflammatory cytokines are involved in the clearance of Plasmodium falciparum during the early stages of the infection, increased levels of these…”
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Cerebral malaria: insight into pathology from optical coherence tomography
Published in Scientific reports (03-08-2021)“…We aimed to investigate structural retinal changes in malarial retinopathy (MR) using hand-held optical coherence tomography (HH-OCT) to assess its diagnostic…”
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Blantyre Malaria Project Epilepsy Study (BMPES) of neurological outcomes in retinopathy-positive paediatric cerebral malaria survivors: a prospective cohort study
Published in Lancet neurology (01-12-2010)“…Summary Background Cerebral malaria, a disorder characterised by coma, parasitaemia, and no other evident cause of coma, is challenging to diagnose…”
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Simulation models predict that school-age children are responsible for most human-to-mosquito Plasmodium falciparum transmission in southern Malawi
Published in Malaria journal (03-04-2018)“…Malaria persists in some high-transmission areas despite extensive control efforts. Progress toward elimination may require effective targeting of specific…”
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Quantitative Assessment of Multiorgan Sequestration of Parasites in Fatal Pediatric Cerebral Malaria
Published in The Journal of infectious diseases (15-10-2015)“…Children in sub-Saharan Africa continue to acquire and die from cerebral malaria, despite efforts to control or eliminate the causative agent, Plasmodium…”
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Genotyping Plasmodium falciparum gametocytes using amplicon deep sequencing
Published in Malaria journal (06-04-2024)“…Understanding the dynamics of gametocyte production in polyclonal Plasmodium falciparum infections requires a genotyping method that detects distinct…”
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Retinal imaging technologies in cerebral malaria: a systematic review
Published in Malaria journal (26-04-2023)“…Cerebral malaria (CM) continues to present a major health challenge, particularly in sub-Saharan Africa. CM is associated with a characteristic malarial…”
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Comparison of CD8 + T Cell Accumulation in the Brain During Human and Murine Cerebral Malaria
Published in Frontiers in immunology (24-07-2019)“…CD8 T cells have been shown to play a critical role in the pathogenesis of experimental cerebral malaria (ECM) in mice, but their role in development of human…”
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Risk factors for acute kidney injury at presentation among children with CNS malaria: a case control study
Published in Malaria journal (01-11-2022)“…Recent research has established that acute kidney injury (AKI) is a common problem in severe paediatric malaria. Limited access to kidney diagnostic studies in…”
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Binding Heterogeneity of Plasmodium falciparum to Engineered 3D Brain Microvessels Is Mediated by EPCR and ICAM-1
Published in mBio (28-05-2019)“…Cerebral malaria is a severe neurological complication associated with sequestration of -infected erythrocytes (IE) in the brain microvasculature, but the…”
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Post hospital admission blood lactate measurements are associated with mortality but not neurologic morbidity in children with cerebral malaria
Published in Malaria journal (19-01-2024)“…In children with cerebral malaria (CM) admission blood lactate has previously guided intravenous fluid therapy and been validated as a prognostic biomarker…”
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School-based screening and treatment may reduce P. falciparum transmission
Published in Scientific reports (25-03-2021)“…In areas where malaria remains entrenched, novel transmission-reducing interventions are essential for malaria elimination. We report the impact…”
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Endothelium-based biomarkers are associated with cerebral malaria in Malawian children: a retrospective case-control study
Published in PloS one (29-12-2010)“…Differentiating cerebral malaria (CM) from other causes of serious illness in African children is problematic, owing to the non-specific nature of the clinical…”
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A systems serology approach to identifying key antibody correlates of protection from cerebral malaria in Malawian children
Published in BMC medicine (12-09-2024)“…Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) proteins are expressed on the surface of infected erythrocytes, mediating parasite sequestration…”
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