Search Results - "Sexton, Sandra"

Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature by Kokolus, Kathleen M., Capitano, Maegan L., Lee, Chen-Ting, Eng, Jason W.-L., Waight, Jeremy D., Hylander, Bonnie L., Sexton, Sandra, Hong, Chi-Chen, Gordon, Christopher J., Abrams, Scott I., Repasky, Elizabeth A.

“…We show here that fundamental aspects of antitumor immunity in mice are significantly influenced by ambient housing temperature. Standard housing temperature…”
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Nrf2 Amplifies Oxidative Stress via Induction of Klf9 by Zucker, Shoshanna N., Fink, Emily E., Bagati, Archis, Mannava, Sudha, Bianchi-Smiraglia, Anna, Bogner, Paul N., Wawrzyniak, Joseph A., Foley, Colleen, Leonova, Katerina I., Grimm, Melissa J., Moparthy, Kalyana, Ionov, Yurij, Wang, Jianmin, Liu, Song, Sexton, Sandra, Kandel, Eugene S., Bakin, Andrei V., Zhang, Yuesheng, Kaminski, Naftali, Segal, Brahm H., Nikiforov, Mikhail A.

“…Reactive oxygen species (ROS) activate NF-E2-related transcription factor 2 (Nrf2), a key transcriptional regulator driving antioxidant gene expression and…”
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Depleting receptor tyrosine kinases EGFR and HER2 overcomes resistance to EGFR inhibitors in colorectal cancer by Yang, Lu, Bhattacharya, Arup, Li, Yun, Sexton, Sandra, Ling, Xiang, Li, Fengzhi, Zhang, Yuesheng

“…Epidermal growth factor receptor (EGFR) inhibitors, including cetuximab and panitumumab, are valuable therapeutics for colorectal cancer (CRC), but resistance…”
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Robot‐assisted approach to ‘W’‐configuration urinary diversion: a step‐by‐step technique by Hussein, Ahmed A., Ahmed, Youssef E., Kozlowski, Justen D., May, Paul R., Nyquist, John, Sexton, Sandra, Curtin, Leslie, Peabody, James O., Abol‐Enein, Hassan, Guru, Khurshid A.

“…Objective To describe a detailed step‐by‐step approach of our technique for robot‐assisted intracorporeal ‘W’‐configuration orthotopic ileal neobladder…”
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Photobac derived from bacteriochlorophyll-a shows potential for treating brain tumor in animal models by photodynamic therapy with desired pharmacokinetics and limited toxicity in rats and dogs by Durrani, Farukh A., Cacaccio, Joseph, Turowski, Steven G., Dukh, Mykhaylo, Bshara, Wiam, Curtin, Leslie, Sexton, Sandra, Spernyak, Joseph A., Pandey, Ravindra K.

“…Photobac is a near infrared photosensitizer (PS) derived from naturally occurring bacteriochlorophyll- a, with a potential for treating a variety of cancer…”
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Using Mice to Model Human Disease: Understanding the Roles of Baseline Housing-Induced and Experimentally Imposed Stresses in Animal Welfare and Experimental Reproducibility by Hylander, Bonnie L, Repasky, Elizabeth A, Sexton, Sandra

“…Mice are the most common animal used to study disease, but there are real concerns about the reproducibility of many of these experiments. This review…”
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Spatiotemporal Optoacoustic Mapping of Tumor Hemodynamics in a Clinically Relevant Orthotopic Rabbit Model of Head and Neck Cancer by Rich, Laurie J, Sexton, Sandra, Curtin, Leslie, Seshadri, Mukund

“…The purpose of this study was to investigate the usefulness of photoacoustic imaging (PAI) for spatiotemporal mapping of tumor hemodynamics in a rabbit model…”
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The Development of Nonthermal Plasma and Tirapazamine as a Novel Combination Therapy to Treat Melanoma In Situ by Yehl, Matthew, Kucharski, Dominik, Eubank, Michelle, Gulledge, Brandon, Rayan, Gamal, Uddin, Md Gias, Remmers, Genevieve, Kandel, Eugene S, DuFaux, Douglas P, Hutcherson, Timothy C, Sexton, Sandra, Zucker, Shoshanna N

“…Although melanoma accounts for only 5.3% of skin cancer, it results in >75% of skin-cancer-related deaths. To avoid disfiguring surgeries on the head and neck…”
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Succinate dehydrogenase inversely regulates red cell distribution width and healthy life span in chronically hypoxic mice by Baysal, Bora E., Alahmari, Abdulrahman A., Rodrick, Tori C., Tabaczynski, Debra, Curtin, Leslie, Seshadri, Mukund, Jones, Drew R., Sexton, Sandra

“…Increased red cell distribution width (RDW), which measures erythrocyte mean corpuscular volume (MCV) variability (anisocytosis), has been linked to early…”
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Phospholipid Encapsulation of an Anti-Fibrotic Endopeptide to Enhance Cellular Uptake and Myocardial Retention by Sonkawade, Swati D, Xu, Shirley, Kim, Minhyung, Nepali, Sarmila, Karambizi, Victoire-Grace, Sexton, Sandra, Turowski, Steven G, Li, Kunpeng, Spernyak, Joseph A, Lovell, Jonathan F, George, Anthony, Suwal, Sujit, Sharma, Umesh C, Pokharel, Saraswati

“…Cardioprotective effects of -acetyl-ser-asp-lys-pro (Ac-SDKP) have been reported in preclinical models of myocardial remodeling. However, the rapid degradation…”
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Novel mouse models of hepatic artery infusion by Kim, Minhyung, MD, Fisher, Daniel T., PhD, Powers, Colin A., MD, Gabriel, Emmanuel M., MD, PhD, Korman, Alexis M, Sexton, Sandra, DVM, Gudkov, Andrei V., PhD, Skitzki, Joseph J., MD, FACS

“…Abstract Background The liver has unique anatomy in that most blood flow to normal hepatocytes is derived from the portal venous system, whereas liver tumors…”
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Imaging of Tumor-Associated Vascular Prostate-Specific Membrane Antigen in Woodchuck Model of Hepatocellular Carcinoma by Sergeeva, Olga, Zhang, Yifan, Julian, Willian, Sasikumar, Arun, Awadallah, Amad, Kenyon, Jonathan, Shi, Wuxian, Sergeev, Maxim, Huang, Steve, Sexton, Sandra, Iyer, Renuka, Xin, Wei, Avril, Norbert, Chan, Ernest Ricky, Lee, Zhenghong

“…Radiolabeled short peptide ligands targeting prostate-specific membrane antigen (PSMA) were developed initially for imaging and treatment of prostate cancers…”
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PET imaging of hepatocellular carcinoma with anti-1-amino-3-[18F]fluorocyclobutanecarboxylic acid in comparison with l-[S-methyl-11C]methionine by Sergeeva, Olga, Zhang, Yifan, Kenyon, Jonathan D., Miller-Atkins, Galen A., Wu, Chunying, Iyer, Renuka, Sexton, Sandra, Wojtylak, Patrick, Awadallah, Amad, Xin, Wei, Chan, E. Ricky, O’Donnel, James K., Lee, Zhenghong

“…Purpose [ 11 C]methionine ([ 11 C]Met) was used for cancer imaging based on upregulated amino acid transport and protein synthesis in different tumor types…”
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Involvement of the renin–angiotensin system in the development of nephrogenic systemic fibrosis-like lesions in the RenTag mouse model by Sexton, Sandra, Tulowitzki, Ryan, Jones, Craig A., Shah, Silvi, Hajduczok, George, Gross, Kenneth W., Panesar, Mandip

“…Background Renin–angiotensin system (RAS) activation increases angiotensin II production stimulating profibrotic factors, especially in the setting of chronic…”
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Effects of a novel peptide Ac-SDKP in radiation-induced coronary endothelial damage and resting myocardial blood flow by Sharma, Umesh C, Sonkawade, Swati D, Baird, Andrew, Chen, Min, Xu, Shirley, Sexton, Sandra, Singh, Anurag K, Groman, Adrienne, Turowski, Steven G, Spernyak, Joseph A, Mahajan, Supriya D, Pokharel, Saraswati

“…Cancer survivors treated with thoracic ionizing radiation are at higher risk of premature death due to myocardial ischemia. No therapy is currently available…”
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How Much Stress Is Too Much? by Sexton, Sandra, Repasky, Elizabeth

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Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer by Alam, Aftab, Levanduski, Eric, Denz, Parker, Villavicencio, Helena Solleiro, Bhatta, Maulasri, Alhorebi, Lamees, Zhang, Yali, Gomez, Eduardo Cortes, Morreale, Brian, Senchanthisai, Sharon, Li, Jun, Turowski, Steven G., Sexton, Sandra, Sait, Sheila Jani, Singh, Prashant K., Wang, Jianmin, Maitra, Anirban, Kalinski, Pawel, DePinho, Ronald A., Wang, Huamin, Liao, Wenting, Abrams, Scott I., Segal, Brahm H., Dey, Prasenjit

“…TH2 cells and innate lymphoid cells 2 (ILC2) can stimulate tumor growth by secreting pro-tumorigenic cytokines such as interleukin-4 (IL-4), IL-5, and IL-13…”
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PET imaging with FAPI-ligands for non-cirrhotic hepatocellular carcinoma by Lee, Zhenghong, Lu, Zheng-Rong, Sexton, Sandra, Xin, Wei

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In Vivo Models for Studying Interstitial Photodynamic Therapy of Locally Advanced Cancer by Shafirstein, Gal, Oakley, Emily, Hamilton, Sasheen, Habitzruther, Michael, Chamberlain, Sarah, Sexton, Sandra, Curtin, Leslie, Bellnier, David A

“…Interstitial photodynamic therapy (I-PDT) is a promising therapy considered for patients with locally advanced cancer. In I-PDT, laser fibers are inserted into…”
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Irradiance controls photodynamic efficacy and tissue heating in experimental tumours: implication for interstitial PDT of locally advanced cancer by Shafirstein, Gal, Bellnier, David A., Oakley, Emily, Hamilton, Sasheen, Habitzruther, Michael, Tworek, Lawrence, Hutson, Alan, Spernyak, Joseph A., Sexton, Sandra, Curtin, Leslie, Turowski, Steven G., Arshad, Hassan, Henderson, Barbara

“…Background Currently delivered light dose (J/cm 2 ) is the principal parameter guiding interstitial photodynamic therapy (I-PDT) of refractory locally advanced…”
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