Search Results - "Sexton, P.M."

Mouse receptor-activity-modifying proteins 1, -2 and -3: amino acid sequence, expression and function by Husmann, Knut, Sexton, P.M, Fischer, J.A, Born, W

“…The calcitonin receptor-like receptor (CRLR) requires novel receptor-activity-modifying proteins (RAMPs) for its function as an adrenomedullin (ADM) or a…”
Get full text

In vitro autoradiographic localization of amylin binding sites in rat brain by Sexton, P M, Paxinos, G, Kenney, M A, Wookey, P J, Beaumont, K

“…Amylin is a recently discovered 37 amino acid peptide which is co-secreted from the pancreas with insulin and acts to modulate carbohydrate metabolism…”
Get more information

In vitro autoradiographic localization of calcitonin and amylin binding sites in monkey brain by Paxinos, G, Chai, S.Y, Christopoulos, G, Huang, X.-F, Toga, A.W, Wang, H.Q, Sexton, P.M

“…Calcitonin (CT) and amylin are related peptides with potent central actions, including suppression of appetite and gastric acid secretion. Little is known…”
Get full text

Calcitonin receptor antibodies in the identification of osteoclasts by Quinn, J.M.W, Morfis, M, Lam, M.H.C, Elliott, J, Kartsogiannis, V, Williams, E.D, Gillespie, M.T, Martin, T.J, Sexton, P.M

“…Osteoclasts are the cells responsible for bone resorption, and their number and rate of formation are critical in determining bone mass. To identify and…”
Get full text

Differential engagement of polar networks in the glucagon-like peptide 1 receptor by endogenous variants of the glucagon-like peptide 1 by Furness, S.G.B., Christopoulos, A., Sexton, P.M., Wootten, D.

“…[Display omitted] The glucagon-like peptide 1 receptor (GLP-1R) can be activated by a number of endogenous peptide hormones, including extended, processed,…”
Get full text

Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs by Bisson, W.H, Cheltsov, A.V, Bruey-Sedano, N, Lin, B, Chen, J, Goldberger, N, May, L.T, Christopoulos, A, Dalton, J.T, Sexton, P.M, Zhang, X.-K, Abagyan, R

“…Finding good drug leads de novo from large chemical libraries, real or virtual, is not an easy task. High-throughput screening is often plagued by low hit…”
Get full text

Amylin receptors: molecular composition and pharmacology by Hay, D L, Christopoulos, G, Christopoulos, A, Sexton, P M

“…Several receptors which bind the hormone AMY (amylin) with high affinity have now been identified. The minimum binding unit is composed of the CT (calcitonin)…”
Get more information

G-protein-coupled receptor allosterism: the promise and the problem(s) by Christopoulos, A, May, L T, Avlani, V A, Sexton, P M

“…Allosteric modulators of G-protein-coupled receptors interact with binding sites that are topographically distinct from the orthosteric site recognized by the…”
Get more information

The pharmacokinetics and pharmacodynamics of Procysteine in amyotrophic lateral sclerosis by Cudkowicz, M.E., Sexton, P.M., Ellis, T., Hayden, D.L., Gwilt, P.R., Whalen, J., Brown, R.H.

Get full text

In vitro autoradiographic localization of the calcitonin receptor isoforms, C1a and C1b, in rat brain by Hilton, J.M., Chai, S.Y., Sexton, P.M.

“…In this study the distribution of the calcitonin receptor isoforms, Cla and Clb, were mapped in rat brain using in vitro autoradiography and manipulation of…”
Get full text

The ontogeny of [125I]rat-alpha-CGRP binding sites in the spinal cord of sheep: a prenatal and postnatal study by Nitsos, I, Sexton, P M, Rees, S

“…In this study we describe the ontogeny of [125I]rat-alpha-calcitonin gene-related peptide binding sites in the spinal cord of fetal and postnatal sheep. The…”
Get more information

Localization of binding sites for calcitonin gene-related peptide in rat brain by in vitro autoradiography by Sexton, P M, McKenzie, J S, Mason, R T, Moseley, J M, Martin, T J, Mendelsohn, F A

“…The distribution of binding sites for calcitonin gene-related peptide (CGRP) in rat brain were studied using in vitro autoradiography. In a radioreceptor assay…”
Get more information

Chicken osteoclasts do not possess calcitonin receptors by Nicholson, G.C., Moseley, J.M., Sexton, P.M., Martin, T.J.

“…Osteoclasts freshly isolated from embryonic chicks have been examined for calcitonin receptors using radio‐iodine‐labeled salmon calcitonin. Calcitonin binding…”
Get full text

Localization and characterization of renal calcitonin receptors by in vitro autoradiography by Sexton, Patrick M., Adam, William R., Moseley, Jane M., Martin, T. John, Mendelsohn, Frederick A.O.

“…Localization and characterization of renal calcitonin receptors by in vitro autoradiography. Calcitonin receptor binding sites were identified in renal cortex…”
Get full text