Search Results - "Sewing, Sabine"

Considerations in the Preclinical Assessment of the Safety of Antisense Oligonucleotides by Goyenvalle, Aurélie, Jimenez-Mallebrera, Cecilia, van Roon, Willeke, Sewing, Sabine, Krieg, Arthur M, Arechavala-Gomeza, Virginia, Andersson, Patrik

“…The nucleic acid therapeutics field has made tremendous progress in the past decades. Continuous advances in chemistry and design have led to many successful…”
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A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium by Adriaenssens, Alice, Lam, Brian Yee Hong, Billing, Lawrence, Skeffington, Katie, Sewing, Sabine, Reimann, Frank, Gribble, Fiona

“…The stomach epithelium contains a myriad of enteroendocrine cells that modulate a range of physiological functions, including postprandial secretion of…”
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Refining LNA safety profile by controlling phosphorothioate stereochemistry by Funder, Erik Daa, Albæk, Nanna, Moisan, Annie, Sewing, Sabine, Koch, Troels

“…Drug discovery with phosphorothioate oligonucleotides is an area of intensive research. In this study we have controlled the stereochemistry of the…”
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Fibroblast Growth Factor-21 Improves Pancreatic β-Cell Function and Survival by Activation of Extracellular Signal–Regulated Kinase 1/2 and Akt Signaling Pathways by WENTE, Wolf, EFANOV, Alexander M, BRENNER, Martin, KHARITONENKOV, Alexei, KÖSTER, Anja, SANDUSKY, George E, SEWING, Sabine, TREINIES, Iris, ZITZER, Heike, GROMADA, Jesper

“…Fibroblast Growth Factor-21 Improves Pancreatic β-Cell Function and Survival by Activation of Extracellular Signal–Regulated Kinase 1/2 and Akt Signaling…”
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Assessing single-stranded oligonucleotide drug-induced effects in vitro reveals key risk factors for thrombocytopenia by Sewing, Sabine, Roth, Adrian B, Winter, Michael, Dieckmann, Andreas, Bertinetti-Lapatki, Cristina, Tessier, Yann, McGinnis, Claudia, Huber, Sylwia, Koller, Erich, Ploix, Corinne, Reed, John C, Singer, Thomas, Rothfuss, Andreas

“…Single-stranded oligonucleotides (ON) comprise a promising therapeutic platform that enables selective modulation of currently undruggable targets. The…”
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Establishment of a Predictive In Vitro Assay for Assessment of the Hepatotoxic Potential of Oligonucleotide Drugs by Sewing, Sabine, Boess, Franziska, Moisan, Annie, Bertinetti-Lapatki, Cristina, Minz, Tanja, Hedtjaern, Maj, Tessier, Yann, Schuler, Franz, Singer, Thomas, Roth, Adrian B

“…Single stranded oligonucleotides (SSO) represent a novel therapeutic modality that opens new space to address previously undruggable targets. In spite of their…”
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Incretin-like effects of small molecule trace amine-associated receptor 1 agonists by Raab, Susanne, Wang, Haiyan, Uhles, Sabine, Cole, Nadine, Alvarez-Sanchez, Ruben, Künnecke, Basil, Ullmer, Christoph, Matile, Hugues, Bedoucha, Marc, Norcross, Roger D, Ottaway-Parker, Nickki, Perez-Tilve, Diego, Conde Knape, Karin, Tschöp, Matthias H, Hoener, Marius C, Sewing, Sabine

“…Abstract Objective Type 2 diabetes and obesity are emerging pandemics in the 21st century creating worldwide urgency for the development of novel and safe…”
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GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells by Sewing, Sabine, Gubler, Marcel, Gérard, Régine, Avignon, Blandine, Mueller, Yasmin, Braendli-Baiocco, Annamaria, Odin, Marielle, Moisan, Annie

“…Targeted delivery of antisense oligonucleotide (AON) drugs is a promising strategy to increase their concentration in the desired tissues and cell types while…”
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Glucose Inhibition of Glucagon Secretion From Rat α-Cells Is Mediated by GABA Released From Neighboring β-Cells by WENDT, Anna, BIRNIR, Bryndis, BUSCHARD, Karsten, GROMADA, Jesper, SALEHI, Albert, SEWING, Sabine, RORSMAN, Patrik, BRAUN, Matthias

“…Glucose Inhibition of Glucagon Secretion From Rat α-Cells Is Mediated by GABA Released From Neighboring β-Cells Anna Wendt 1 , Bryndis Birnir 1 , Karsten…”
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Investigating discovery strategies and pharmacological properties of stereodefined phosphorodithioate LNA gapmers by Duschmalé, Jörg, Schäublin, Adrian, Funder, Erik, Schmidt, Steffen, Kiełpiński, Łukasz J., Nymark, Helle, Jensen, Klaus, Koch, Troels, Duschmalé, Martina, Koller, Erich, Møller, Marianne Ravn, Schadt, Simone, Husser, Christophe, Brink, Andreas, Sewing, Sabine, Minz, Tanja, Wengel, Jesper, Bleicher, Konrad, Li, Meiling

“…The introduction of sulfur into the phosphate linkage of chemically synthesized oligonucleotides creates the stereocenters on phosphorus atoms. Researchers…”
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Liver X Receptor Activation Stimulates Insulin Secretion via Modulation of Glucose and Lipid Metabolism in Pancreatic Beta-Cells by EFANOV, Alexander M, SEWING, Sabine, BOKVIST, Krister, GROMADA, Jesper

“…Liver X receptors (LXRs) alpha and beta, transcription factors of a nuclear hormone receptor family, are expressed in pancreatic islets as well as…”
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Inhibition of EGF Uptake by Nephrotoxic Antisense Drugs In Vitro and Implications for Preclinical Safety Profiling by Moisan, Annie, Gubler, Marcel, Zhang, Jitao David, Tessier, Yann, Dumong Erichsen, Kamille, Sewing, Sabine, Gérard, Régine, Avignon, Blandine, Huber, Sylwia, Benmansour, Fethallah, Chen, Xing, Villaseñor, Roberto, Braendli-Baiocco, Annamaria, Festag, Matthias, Maunz, Andreas, Singer, Thomas, Schuler, Franz, Roth, Adrian B.

“…Antisense oligonucleotide (AON) therapeutics offer new avenues to pursue clinically relevant targets inaccessible with other technologies. Advances in…”
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A Novel Glucokinase Activator Modulates Pancreatic Islet and Hepatocyte Function by Efanov, Alexander M, Barrett, David G, Brenner, Martin B, Briggs, Stephen L, Delaunois, Annie, Durbin, Jim D, Giese, Ulrich, Guo, Haihong, Radloff, Mark, Gil, Gema Sanz, Sewing, Sabine, Wang, Yong, Weichert, Andreas, Zaliani, Andrea, Gromada, Jesper

“…The glucose-sensing enzyme glucokinase (GK) plays a key role in glucose metabolism. We report here the effects of a novel glucokinase activator, LY2121260. The…”
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SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells by Eliasson, Lena, Ma, Xiaosong, Renström, Erik, Barg, Sebastian, Berggren, Per-Olof, Galvanovskis, Juris, Gromada, Jesper, Jing, Xingjun, Lundquist, Ingmar, Salehi, Albert, Sewing, Sabine, Rorsman, Patrik

“…Measurements of membrane capacitance were applied to dissect the cellular mechanisms underlying PKA-dependent and -independent stimulation of insulin secretion…”
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Immunohistochemical localization of five members of the Kv1 channel subunits: contrasting subcellular locations and neuron-specific co-localizations in rat brain by Veh, R W, Lichtinghagen, R, Sewing, S, Wunder, F, Grumbach, I M, Pongs, O

“…A large variety of potassium channels is involved in regulating integration and transmission of electrical signals in the nervous system. Different types of…”
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Heteromultimeric channels formed by rat brain potassium-channel proteins by Ruppersberg, J. Peter, Schröter, Klaus H, Sakmann, Bert, Stocker, Martin, Sewing, Sabine, Pongs, Olaf

“…An important step towards understanding the molecular basis of the functional diversity of voltage-gated K+ channels in the mammalian brain has been the…”
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In Vitro Assessment of the Hepatotoxicity Potential of Therapeutic Oligonucleotides by Sewing, Sabine, Minz, Tanja, Boess, Franziska

“…The mechanisms of antisense oligonucleotide-induced liver toxicity are still poorly understood. Assessment of the hepatic safety profile is currently mostly…”
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Safety, Tissue Distribution, and Metabolism of LNA-Containing Antisense Oligonucleotides in Rats by Romero-Palomo, Fernando, Festag, Matthias, Lenz, Barbara, Schadt, Simone, Brink, Andreas, Kipar, Anja, Steinhuber, Bernd, Husser, Christophe, Koller, Erich, Sewing, Sabine, Tessier, Yann, Dzygiel, Pawel, Fischer, Guy, Winter, Michael, Hetzel, Udo, Mihatsch, Michael J., Braendli-Baiocco, Annamaria

“…Antisense oligonucleotides (ASOs) are chemically modified nucleic acids with therapeutic potential, some of which have been approved for marketing. We…”
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Evaluation of bovine milk extracellular vesicles for the delivery of locked nucleic acid antisense oligonucleotides by Grossen, Philip, Portmann, Michaela, Koller, Erich, Duschmalé, Martina, Minz, Tanja, Sewing, Sabine, Pandya, Nikhil Janak, van Geijtenbeek, Sabine Kux, Ducret, Axel, Kusznir, Eric-André, Huber, Sylwia, Berrera, Marco, Lauer, Matthias E., Ringler, Philippe, Nordbo, Bettina, Jensen, Marianne Lerbech, Sladojevich, Filippo, Jagasia, Ravi, Alex, Rainer, Gamboni, Remo, Keller, Michael

“…[Display omitted] The natural capacity of extracellular vesicles (EVs) to transport their payload to recipient cells has raised big interest to repurpose EVs…”
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Combining In Vivo and Organotypic In Vitro Approaches to Assess the Human Relevance of Basimglurant (RG7090), a Potential CAR Activator by Nudischer, Ramona, Renggli, Kasper, Bertinetti-Lapatki, Cristina, Hoflack, Jean-Christophe, Flint, Nicholas, Sewing, Sabine, Pedersen, Lykke, Schadt, Simone, Higgins, Larry G, Vardy, Audrey, Lenz, Barbara, Gand, Laurent, Boess, Franziska, Elcombe, Barbara M, Hierlemann, Andreas, Roth, Adrian B

“…Abstract Basimglurant (RG7090), a small molecule under development to treat certain forms of depression, demonstrated foci of altered hepatocytes in a…”
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