Search Results - "Sewell, Robert D. E."

A streptozotocin-induced diabetic neuropathic pain model for static or dynamic mechanical allodynia and vulvodynia: validation using topical and systemic gabapentin by Ali, Gowhar, Subhan, Fazal, Abbas, Muzaffar, Zeb, Jehan, Shahid, Muhammad, Sewell, Robert D. E.

“…Neuropathic vulvodynia is a state of vulval discomfort characterized by a burning sensation, diffuse pain, pruritus or rawness with an acute or chronic onset…”
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Efficacy of a topical gabapentin gel in a cisplatin paradigm of chemotherapy-induced peripheral neuropathy by Shahid, Muhammad, Subhan, Fazal, Ahmad, Nisar, Sewell, Robert D E

“…Chemotherapy induced peripheral neuropathy (CIPN) has been attributed to chemotherapeutic agents such as cisplatin which adversely affect disease outcome…”
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Antioxidants and Atherosclerosis: Mechanistic Aspects by Malekmohammad, Khojasteh, Sewell, Robert D E, Rafieian-Kopaei, Mahmoud

“…Atherosclerosis is a chronic inflammatory disease which is a major cause of coronary heart disease and stroke in humans. It is characterized by intimal plaques…”
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S100A9 Protein Aggregates Boost Hippocampal Glutamate Modifying Monoaminergic Neurochemistry: A Glutamate Antibody Sensitive Outcome on Alzheimer-like Memory Decline by Gruden, Marina A, Davydova, Tatiana V, Kudrin, Vladimir S, Wang, Chao, Narkevich, Victor B, Morozova-Roche, Ludmilla A, Sewell, Robert D. E

“…Alzheimer’s disease (AD) involves dementia conceivably arising from integrated inflammatory processes, amyloidogenesis, and neuronal apoptosis. Glutamate can…”
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Intranasal administration of alpha-synuclein aggregates: a Parkinson's disease model with behavioral and neurochemical correlates by Gruden, Marina A., Davydova, Tatiana V., Narkevich, Victor B., Fomina, Valentina G., Wang, Chao, Kudrin, Vladimir S., Morozova-Roche, Ludmilla A., Sewell, Robert D.E.

“…•α-Synuclein fibrils and/or oligomers were given intranasally for 14 days in mice.•Combined oligomers+fibrils caused rigidity and locomotor impairment.•Nigral…”
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Inflammasome Signaling and Other Factors Implicated in Atherosclerosis Development and Progression by Nazarian-Samani, Zeinab, Sewell, Robert D E, Rafieian-Kopaei, Mahmoud

“…Chronic inflammation plays an extensive role in the onset and progression of metabolic disorders such as atherosclerosis, type 2 diabetes, gout and obesity…”
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Fraxetin attenuates disrupted behavioral and central neurochemical activity in a model of chronic unpredictable stress by Ahmed, Zainab, Tokhi, Ahmed, Arif, Mehreen, Rehman, Naeem Ur, Sheibani, Vahid, Rauf, Khalid, Sewell, Robert D E

“…Chronic unpredictable stress (CUS) induces long-term neuronal and synaptic plasticity with a neurohormonal disbalance leading to the development of co-existing…”
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Diosgenin normalization of disrupted behavioral and central neurochemical activity after single prolonged stress by Malik, Hurmat, Usman, Muhammad, Arif, Mehreen, Ahmed, Zainab, Ali, Gowhar, Rauf, Khalid, Sewell, Robert D. E.

“…Introduction: Post-traumatic stress disorder (PTSD) is a chronic mental illness triggered by traumatic experiences such as wars, natural disasters, or…”
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A Review on the Most Important Medicinal Plants Effective in Cardiac Ischemia-Reperfusion Injury by Sedighi, Mehrnoosh, Sewell, Robert D E, Nazari, Afshin, Abbaszadeh, Saber, Cheraghi, Mostafa, Amini, Abdolhakim, Heydari, Zahra, Rafieian-Kopaei, Mahmoud

“…Ischemia, referring to reduction and restriction of perfusion to myocardial tissue which involves coronary artery through the formation of misplaced clots and…”
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5,7-Dimethoxycoumarin ameliorates vincristine induced neuropathic pain: potential role of 5HT3 receptors and monoamines by Usman, Muhammad, Malik, Hurmat, Tokhi, Ahmed, Arif, Mehreen, Huma, Zilli, Rauf, Khalid, Sewell, Robert D. E.

“…Vincristine is the drug of choice for Hodgkin’s lymphoma, acute lymphoblastic leukemia, and non-Hodgkin lymphoma. Despite its significant anticancer effects,…”
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Effects of 1-methyl-1, 2, 3, 4-tetrahydroisoquinoline on a diabetic neuropathic pain model by Tokhi, Ahmed, Ahmed, Zainab, Arif, Mehreen, Rehman, Naeem Ur, Sheibani, Vahid, Sewell, Robert D E, Rauf, Khalid

“…Neuropathy is a prevalent and debilitating complication of poorly managed diabetes, contributing towards poor quality of life, amputation risk, and increased…”
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Pharmacological evaluation of the gabapentin salicylaldehyde derivative, gabapentsal, against tonic and phasic pain models, inflammation, and pyrexia by Ahmad, Nisar, Subhan, Fazal, Islam, Nazar Ul, Shahid, Muhammad, Ullah, Naseem, Ullah, Rahim, Khurram, Muhammad, Amin, Muhammad Usman, Akbar, Shehla, Ullah, Ihsan, Sewell, Robert D. E.

“…Gabapentinoids are effective drugs in most animal models of pain and inflammation with variable effects in humans. The current study evaluated the…”
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The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer's disease model by Ostrovskaya, Rita U., Gruden, Marina A., Bobkova, Natalya A., Sewell, Robert D. E., Gudasheva, Tatyana A., Samokhin, Alexander N., Seredinin, Sergey B., Noppe, Wim, Sherstnev, Vladimir V., Morozova-Roche, Ludmilla A.

“…The effects of the novel proline-containing nootropic and neuroprotective dipeptide, noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) were…”
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A Bacoside Containing Bacopa monnieri Extract Reduces Both Morphine Hyperactivity Plus the Elevated Striatal Dopamine and Serotonin Turnover by Rauf, Khalid, Subhan, Fazal, Sewell, Robert D. E.

“…Bacopa monnieri (BM) has been used in Ayurvedic medicine as a nootropic, anxiolytic, antiepileptic and antidepressant. An n‐butanol extract of the plant…”
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Selected Thiadiazine-Thione Derivatives Attenuate Neuroinflammation in Chronic Constriction Injury Induced Neuropathy by Qureshi, Sonia, Ali, Gowhar, Idrees, Muhammad, Muhammad, Tahir, Kong, Il-Keun, Abbas, Muzaffar, Shah, Muhammad Ishaq Ali, Ahmad, Sajjad, Sewell, Robert D E, Ullah, Sami

“…Neuropathic pain refers to a lesion or disease of peripheral and/or central somatosensory neurons and is an important body response to actual or potential…”
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Synthetic and natural antioxidants attenuate cisplatin-induced vomiting by Alam, Javaid, Subhan, Fazal, Ullah, Ihsan, Shahid, Muhammad, Ali, Gowhar, Sewell, Robert D E

“…Synthetic and natural antioxidants including Bacopa monnieri (L.) Pennell (Scrophulariaceae) which also possess anti-dopaminergic properties, have been…”
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Intranasally Administered S100A9 Amyloids Induced Cellular Stress, Amyloid Seeding, and Behavioral Impairment in Aged Mice by Iashchishyn, Igor A, Gruden, Marina A, Moskalenko, Roman A, Davydova, Tatiana V, Wang, Chao, Sewell, Robert D. E, Morozova-Roche, Ludmilla A

“…Amyloid formation and neuroinflammation are major features of Alzheimer’s disease pathology. Proinflammatory mediator S100A9 was shown to act as a link between…”
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Effect of Gabapentin-Fluoxetine Derivative GBP1F in a Murine Model of Depression, Anxiety and Cognition by Gohar, Aneela, Ali, Gowhar, Rashid, Umer, Rauf, Khalid, Arif, Mehreen, Khan, Muhammad Sona, Alkahramaan, Yasser M S A, Sewell, Robert D E

“…Gabapentin is a commonly prescribed antiepileptic agent for seizures, which is also used for pain and addiction management. Due to growing evidence of its…”
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The misfolded pro-inflammatory protein S100A9 disrupts memory via neurochemical remodelling instigating an Alzheimer’s disease-like cognitive deficit by Gruden, Marina A., Davydova, Tatiana V., Wang, Chao, Narkevich, Victor B., Fomina, Valentina G., Kudrin, Vladimir S., Morozova-Roche, Ludmilla A., Sewell, Robert D.E.

“…•Protein S100A9 oligomers and/or fibrils were given intranasally for 14 days in mice.•S100A9 oligomers and fibrils but not their mixture evoked passive…”
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Comparative evaluation of gastroulcerogenic potential of nitrogen isoforms of salicyl alcohol and aspirin in rats: biochemical and histological study by Ali, Gowhar, Subhan, Fazal, Islam, Nazar Ul, Ullah, Nasir, Shahid, Muhammad, Ullah, Sami, Ullah, Ihsan, Shah, Rehmat, Khan, Ikhtiar, Sewell, Robert D. E, Abbas, Ghulam

“…The aim of the current study was to explore in vivo any relative gastroulcerogenic prospective propensity of newly synthesized nitrogen containing derivatives…”
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