Search Results - "Sewastianik, Tomasz"

BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins by Jiang, Meng, Kang, Yue, Sewastianik, Tomasz, Wang, Jiao, Tanton, Helen, Alder, Keith, Dennis, Peter, Xin, Yu, Wang, Zhongqiu, Liu, Ruiyang, Zhang, Mengyun, Huang, Ying, Loda, Massimo, Srivastava, Amitabh, Chen, Runsheng, Liu, Ming, Carrasco, Ruben D.

“…Colorectal cancer (CRC) is the third most commonly diagnosed cancer, which despite recent advances in treatment, remains incurable due to molecular…”
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A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation by Lazarian, Gregory, Yin, Shanye, ten Hacken, Elisa, Sewastianik, Tomasz, Uduman, Mohamed, Font-Tello, Alba, Gohil, Satyen H., Li, Shuqiang, Kim, Ekaterina, Joyal, Heather, Billington, Leah, Witten, Elizabeth, Zheng, Mei, Huang, Teddy, Severgnini, Mariano, Lefebvre, Valerie, Rassenti, Laura Z., Gutierrez, Catherine, Georgopoulos, Katia, Ott, Christopher J., Wang, Lili, Kipps, Thomas J., Burger, Jan A., Livak, Kenneth J., Neuberg, Donna S., Baran-Marszak, Fanny, Cymbalista, Florence, Carrasco, Ruben D., Wu, Catherine J.

“…Hotspot mutation of IKZF3 (IKZF3-L162R) has been identified as a putative driver of chronic lymphocytic leukemia (CLL), but its function remains unknown. Here,…”
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FOXO1 activation is an effector of SYK and AKT inhibition in tonic BCR signal-dependent diffuse large B-cell lymphomas by Szydlowski, Maciej, Kiliszek, Przemyslaw, Sewastianik, Tomasz, Jablonska, Ewa, Bialopiotrowicz, Emilia, Gorniak, Patryk, Polak, Anna, Markowicz, Sergiusz, Nowak, Eliza, Grygorowicz, Monika A., Prochorec-Sobieszek, Monika, Szumera-Cieckiewicz, Anna, Malenda, Agata, Lech-Maranda, Ewa, Warzocha, Krzysztof, Juszczynski, Przemyslaw

“…Inhibition of spleen tyrosine kinase (SYK) in tonic B-cell receptor (BCR) signal-dependent diffuse large B-cell lymphomas (DLBCLs) inhibits cellular…”
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SIRT1 and HSP90α feed-forward circuit safeguards chromosome segregation integrity in diffuse large B cell lymphomas by Białopiotrowicz-Data, Emilia, Noyszewska-Kania, Monika, Jabłońska, Ewa, Sewastianik, Tomasz, Komar, Dorota, Dębek, Sonia, Garbicz, Filip, Wojtas, Magdalena, Szydłowski, Maciej, Polak, Anna, Górniak, Patryk, Juszczyński, Przemysław

“…Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-Hodgkin lymphoma in adults, exhibiting highly heterogenous clinical behavior and…”
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MEK Inhibition Sensitizes Precursor B-Cell Acute Lymphoblastic Leukemia (B-ALL) Cells to Dexamethasone through Modulation of mTOR Activity and Stimulation of Autophagy by Polak, Anna, Kiliszek, Przemysław, Sewastianik, Tomasz, Szydłowski, Maciej, Jabłońska, Ewa, Białopiotrowicz, Emilia, Górniak, Patryk, Markowicz, Sergiusz, Nowak, Eliza, Grygorowicz, Monika A, Prochorec-Sobieszek, Monika, Nowis, Dominika, Gołąb, Jakub, Giebel, Sebastian, Lech-Marańda, Ewa, Warzocha, Krzysztof, Juszczyński, Przemysław

“…Resistance to glucocorticosteroids (GCs) is a major adverse prognostic factor in B-ALL, but the molecular mechanisms leading to GC resistance are not…”
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Constitutive Ras signaling and Ink4a/Arf inactivation cooperate during the development of B-ALL in mice by Sewastianik, Tomasz, Jiang, Meng, Sukhdeo, Kumar, Patel, Sanjay S., Roberts, Kathryn, Kang, Yue, Alduaij, Ahmad, Dennis, Peter S., Lawney, Brian, Liu, Ruiyang, Song, Zeyuan, Xiong, Jessie, Zhang, Yunyu, Lemieux, Madeleine E., Pinkus, Geraldine S., Rich, Jeremy N., Weinstock, David M., Mullighan, Charles G., Sharpless, Norman E., Carrasco, Ruben D.

“…Despite recent advances in treatment, human precursor B-cell acute lymphoblastic leukemia (B-ALL) remains a challenging clinical entity. Recent genome-wide…”
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Nanoparticles for Immune Cytokine TRAIL-Based Cancer Therapy by Guimarães, Pedro P.G, Gaglione, Stephanie, Sewastianik, Tomasz, Carrasco, Ruben D, Langer, Robert, Mitchell, Michael J

“…The immune cytokine tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has received significant attention as a cancer therapeutic due to its…”
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MYC deregulation in lymphoid tumors: molecular mechanisms, clinical consequences and therapeutic implications by Sewastianik, Tomasz, Prochorec-Sobieszek, Monika, Chapuy, Bjoern, Juszczyński, Przemysław

“…MYC is one of the most frequently deregulated oncogenes in human malignancies. It encodes a leucine zipper transcription factor that modulates a broad spectrum…”
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ATTAC-MCC: Phase I/II study of autologous CD8+ and CD4+ transgenic T cells expressing a high affinity MCPyV-specific TCR combined with checkpoint inhibitors and class I MHC-upregulation in patients with metastatic MCC refractory to PD-1 axis blockade by Veatch, Joshua, Akkiraju, Ananth, Darwanto, Agus, Garrity, Sean, Hallet, Damien, Nguyen, Kim, Pierog, Piotr, Sewastianik, Tomasz, Vallaster, Markus P, Vincent, Loic, Chapuis, Aude

“…TPS9596 Background: Merkel cell carcinoma (MCC) is a highly aggressive skin cancer, with an incidence that has doubled in the last 20 years to approximately…”
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In vivo bone marrow microenvironment siRNA delivery using lipid-polymer nanoparticles for multiple myeloma therapy by Guimarães, Pedro P G, Figueroa-Espada, Christian G, Riley, Rachel S, Gong, Ningqiang, Xue, Lulu, Sewastianik, Tomasz, Dennis, Peter S, Loebel, Claudia, Chung, Amanda, Shepherd, Sarah J, Haley, Rebecca M, Hamilton, Alex G, El-Mayta, Rakan, Wang, Karin, Langer, Robert, Anderson, Daniel G, Carrasco, Ruben D, Mitchell, Michael J

“…Multiple myeloma (MM), a hematologic malignancy that preferentially colonizes the bone marrow, remains incurable with a survival rate of 3 to 6 mo for those…”
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Ubiquitin receptor PSMD4/Rpn10 is a novel therapeutic target in multiple myeloma by Du, Ting, Song, Yan, Ray, Arghya, Wan, Xueping, Yao, Yao, Samur, Mehmet K., Shen, Chen, Penailillo, Johany, Sewastianik, Tomasz, Tai, Yu-Tzu, Fulciniti, Mariateresa, Munshi, Nikhil C., Wu, Hao, Carrasco, Ruben D., Chauhan, Dharminder, Anderson, Kenneth C.

“…•Rpn10 plays a pivotal role in MM.•A novel Rpn10 inhibitor, SB, was identified via AlphaScreen. [Display omitted] PSMD4/Rpn10 is a subunit of the 19S…”
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MiR-17-92 represses PTPROt and PP2A phosphatases and amplifies tonic BCR signaling in DLBCL cells by Jablonska, Ewa, Gorniak, Patryk, Szydlowski, Maciej, Sewastianik, Tomasz, Bialopiotrowicz, Emilia, Polak, Anna, Warzocha, Krzysztof, Juszczynski, Przemyslaw

“…Abstract B-cell receptor (BCR) signaling plays pivotal role in the pathogenesis of diffuse large B-cell lymphomas (DLBCL), and targeting the BCR pathway is a…”
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Bortezomib induces anti-multiple myeloma immune response mediated by cGAS/STING pathway activation by Gulla, Annamaria, Morelli, Eugenio, Samur, Mehmet K, Botta, Cirino, Hideshima, Teru, Bianchi, Giada, Fulciniti, Mariateresa, Malvestiti, Stefano, Prabhala, Rao H, Talluri, Srikanth, Wen, Kenneth, Tai, Yu-Tzu, Richardson, Paul G, Chauhan, Dharminder, Sewastianik, Tomasz, Carrasco, Ruben D, Munshi, Nikhil C, Anderson, Kenneth C

“…Proteasome inhibitor bortezomib induces apoptosis in multiple myeloma (MM) cells, and has transformed patient outcome. Using as well as immunodeficient and…”
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Atypical Stem Cell, Pre-B-Cell, T-Cell and Myeloid Gene Expression Characterizes Early Waldenstrom's Macroglobulinemia Clones Which Diminishes with Advancing Disease and Has Therapeutic Implications by Hunter, Zachary R, Guerrera, Maria Luisa, Carrasco, Ruben D., Tsakmaklis, Nickolas, Richardson, Kris, Kofides, Amanda, Liu, Xia, Liu, Shirong, Flynn, Catherine A., Meid, Kirsten, Gustine, Joshua, Patterson, Christopher J, Fulciniti, Mariateresa, Samur, Mehmet K., Sewastianik, Tomasz, Anderson, Kenneth C., Munshi, Nikhil C, Sarosiek, Shayna R, Castillo, Jorge J., Treon, Steven P

“…Background: In previous studies using multi-omic data for 253 treatment-naive patients with Waldenstrom's Macroglobulinemia (WM), we identified three subtypes…”
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Expression of PIM kinases in Reed-Sternberg cells fosters immune privilege and tumor cell survival in Hodgkin lymphoma by Szydłowski, Maciej, Prochorec-Sobieszek, Monika, Szumera-Ciećkiewicz, Anna, Derezińska, Edyta, Hoser, Grażyna, Wasilewska, Danuta, Szymańska-Giemza, Olga, Jabłońska, Ewa, Białopiotrowicz, Emilia, Sewastianik, Tomasz, Polak, Anna, Czardybon, Wojciech, Gałęzowski, Michał, Windak, Renata, Zaucha, Jan Maciej, Warzocha, Krzysztof, Brzózka, Krzysztof, Juszczyński, Przemysław

“…Reed-Sternberg (RS) cells of classical Hodgkin lymphoma (cHL) express multiple immunoregulatory proteins that shape the cHL microenvironment and allow tumor…”
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Super-Enhancer-Driven PIM Kinase Upregulation in Multiple Myeloma Maintains the Plasma Cell-Specific Oncogenic and Microenvironmental Circuits, and Can be Efficiently Targeted By the Pan-PIM Inhibitor MEN1703 by Garbicz, Filip, Debek, Sonia, Szumera-Ciećkiewicz, Anna, Barankiewicz, Joanna, Komar, Dorota, Pawlak, Michał, Matrejek, Aleksandra, Stuehmer, Thorsten, Salomon-Perzynski, Aleksander, Malenda, Agata, Ostrowska, Julia, Dudkiewicz, Julia, Brzózka, Krzysztof, Rzymski, Tomasz, Bellarosa, Daniela, Lech-Marańda, Ewa, Prochorec-Sobieszek, Monika, Pilch, Zofia, Nowis, Dominika, Golab, Jakub, Tanton, Helen, Hideshima, Teru, Dorfman, David M., Misiewicz-Krzeminska, Irena, Sewastianik, Tomasz, Carrasco, Ruben D., Szydlowski, Maciej, Juszczynski, Przemyslaw

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The ERK1/2 Regulator WNK2 Shows Novel Alternative Splicing Aberrations That Support Tumor Growth in MYD88 Mutated Waldenström's Macroglobulinemia by Guerrera, Maria Luisa, Liu, Xia, Morelli, Eugenio, Richardson, Kris, Tsakmaklis, Nickolas, Kofides, Amanda, Munshi, Manit, Liu, Shirong, Yang, Guang, Patterson, Christopher J, Castillo, Jorge J., Sarosiek, Shayna, Flynn, Catherine A., Meid, Kirsten, Gustine, Joshua, Branagan, Andrew R., Trojani, Alessandra, Tedeschi, Alessandra, Cairoli, Roberto, Sewastianik, Tomasz, Carrasco, Ruben D., Anderson, Kenneth C., Munshi, Nikhil C, Treon, Steven P, Hunter, Zachary R

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SIRT1 and HSP90alpha Are Functionally Linked and Control Mitotic Chromosome Segregation and Cell Viability in a Subset of Dlbcls by Bialopiotrowicz, Emilia, Noyszewska-Kania, Monika, Jabłońska, Ewa, Sewastianik, Tomasz, Stańczak, Monika, Szumera-Ciećkiewicz, Anna, Borg, Katarzyna, Bluszcz, Aleksandra, Dębek, Sonia, Prochorec-Sobieszek, Monika, Polak, Anna, Górniak, Patryk, Szydlowski, Maciej, Juszczynski, Przemyslaw

“…Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-Hodgkin lymphoma in adults, exhibiting highly heterogenous clinical behavior and…”
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Overexpression of BCL9, a Wnt/β-Catenin Transcriptional Co-Activator, in Transgenic Mice Promotes Spontaneous Development of B-Cell Malignancies by Sewastianik, Tomasz, Zhao, Jianjun, Jiang, Meng, Dennis, Peter S., Brown, Myles, Wong, Kwok, Carrasco, Ruben D.

“…Dysregulation of the Wnt signaling pathway underlies the pathogenesis of a wide range of human cancers, including hematological malignancies such as multiple…”
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The ERK1/2 Regulator WNK2 Shows Differential Expression and Isoform Usage, Primarily Driven By Aberrant Methylation, in MYD88 Mutated Waldenström's Macroglobulinemia by Guerrera, Maria Luisa, Yang, Guang, Liu, Xia, Tsakmaklis, Nickolas, Demos, Maria G, Kofides, Amanda, Munshi, Manit, Xu, Lian, Patterson, Christopher J, Castillo, Jorge J., Sarosiek, Shayna, Flynn, Catherine A, Meid, Kirsten, Gustine, Joshua, Sewastianik, Tomasz, Carrasco, Ruben D., Treon, Steven P, Hunter, Zachary R

“…MYD88 mutations (MYD88 MUT) are present in 95-97% of patients with Waldenström's Macroglobulinemia (WM). Transgenic mouse studies show that MYD88 MUT alone is…”
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