Search Results - "Sevim, Cigdem"

Identifying disease-causing mutations in genomes of single patients by computational approaches by Sevim Bayrak, Cigdem, Itan, Yuval

“…Over the last decade next generation sequencing (NGS) has been extensively used to identify new pathogenic mutations and genes causing rare genetic diseases…”
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Cardiovascular disease and toxic metals by Sevim, Çiğdem, Doğan, Elif, Comakli, Selim

“…Heavy metal exposure can lead to death and disability. A variety of sources including soil, wastewater, mining activities, industrial waste, sewage wastes,…”
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RAG-3D: a search tool for RNA 3D substructures by Zahran, Mai, Sevim Bayrak, Cigdem, Elmetwaly, Shereef, Schlick, Tamar

“…To address many challenges in RNA structure/function prediction, the characterization of RNA's modular architectural units is required. Using the RNA-As-Graphs…”
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De novo variants in exomes of congenital heart disease patients identify risk genes and pathways by Sevim Bayrak, Cigdem, Zhang, Peng, Tristani-Firouzi, Martin, Gelb, Bruce D, Itan, Yuval

“…Congenital heart disease (CHD) affects ~ 1% of live births and is the most common birth defect. Although the genetic contribution to the CHD has been long…”
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Effects of chlorpyrifos-methyl, chlormequat, deltamethrin, glyphosate, pirimiphos-methyl, tebuconazole and their mixture on oxidative stress and toxicity in HUVEC cell line by Sevim,Çiğdem, Taghizadehghalehjoughi,Ali, Kara,Mehtap

“…Background and Aims: Humans and animals have daily contact with various chemicals, including food additives, pesticides, antibiotics, other veterinary drugs,…”
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Genome-wide prediction of pathogenic gain- and loss-of-function variants from ensemble learning of a diverse feature set by Stein, David, Kars, Meltem Ece, Wu, Yiming, Bayrak, Çiğdem Sevim, Stenson, Peter D, Cooper, David N, Schlessinger, Avner, Itan, Yuval

“…Gain-of-function (GOF) variants give rise to increased/novel protein functions whereas loss-of-function (LOF) variants lead to diminished protein function…”
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Apoptosis is induced by sub-acute exposure to 3-MCPD and glycidol on Wistar Albino rat brain cells by Sevim, Çiğdem, Özkaraca, Mustafa, Kara, Mehtap, Ulaş, Nergis, Mendil, Ali Sefa, Margina, Denisa, Tsatsakis, Aristidis

“…•3-MCPD and its metabolite glycidol are important food contaminats.•There was apoptosis in the cerebellum by the in 3-MCDP (10 mg/kg) and Glycidol (375 mg/kg)…”
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In Vitro Investigation of the Effects of Imidacloprid on AChE, LDH, and GSH Levels in the L-929 Fibroblast Cell Line by Sevİm, Çiğdem, Taghİzadehghalehjoughİ, Ali, Kara, Mehtap

“…There are several types of pesticides to control pests and several new types coming into use that could be less toxic compared to the old ones…”
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The sesquiterpenoid valerenic acid protects neuronal cells from the detrimental effects of the fungicide benomyl on apoptosis and DNA oxidation by Kara, Mehtap, Öztaş, Ezgi, Boran, Tuğçe, Sevim, Çiğdem, Keskin, Seda Eren, Veskoukis, Aristidis S, Kuzmin, Sergei V, Tsatsakis, Aristides M

“…Background Valerenic acid (VA), a sesquiterpenoid of the plant Valeriana officinalis, has attracted attention of the research community due to its potential…”
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Evaluation of pten and Pi3k/Akt expressions in stanozolol-treated rat kidneys by Kotil,Tuğba, Sevim,Çiğdem, Kara,Mehtap

“…Objective: Stanozolol is an anabolic androgenic steroid (AAS) that is widely used by teenagers and athletes in bodybuilding, sports, and athletics. The…”
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Cadmium sulfide-induced toxicity in the cortex and cerebellum: In vitro and in vivo studies by Varmazyari, Atefeh, Taghizadehghalehjoughi, Ali, Sevim, Cigdem, Baris, Ozlem, Eser, Gizem, Yildirim, Serkan, Hacimuftuoglu, Ahmet, Buha, Aleksandra, Wallace, David R., Tsatsakis, Aristidis, Aschner, Michael, Mezhuev, Yaroslav

“…[Display omitted] •CdS NPs were synthesized using living organisms Viridibacillus arenosi K64.•Morphology and size of NP were evaluated by XRD and SEM.•In…”
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Reproductive Effects of S. boulardii on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats by Sevim, Çiğdem, Akpınar, Erol, Aksu, Emrah Hicazi, Ömür, Ali Doğan, Yıldırım, Serkan, Kara, Mehtap, Bolat, İsmail, Tsatsakis, Aristides, Mesnage, Robin, Golokhvast, Kirill S, Uzunçakmak, Sevgi Karabulut, Ersoylu, Rabia Nilüfer

“…The potential health-promoting effects of probiotics against intoxication by pesticides is a topic of increasing commercial interest with limited scientific…”
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The Immunostimulatory Effect of Lactic Acid Bacteria in a Rat Model by Karamese, Murat, Aydin, Hakan, Sengul, Emin, Gelen, Volkan, Sevim, Cigdem, Ustek, Duran, Karakus, Emre

“…Probiotics are "live", beneficial microbes that provide important health benefits in their hosts. There is significant interest in the modulation and…”
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An imazamox-based herbicide causes apoptotic changes in rat liver and pancreas by Sevim, Çiğdem, Çomaklı, Selim, Taghizadehghalehjoughi, Ali, Özkaraca, Mustafa, Mesnage, Robin, Kovatsi, Leda, Burykina, Tatyana I., Kalogeraki, Alexandra, Antoniou, Michael N., Tsatsakis, Aristidis

“…[Display omitted] •Toxicity of an imazamox-based herbicide was evaluated in rats.•Blood samples were collected and serum ALP, AST, glucose, calcium and…”
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Corrigendum to “Cadmium sulfide-induced toxicity in the cortex and cerebellum: In vitro and in vivo studies” [Toxicol. Rep. 7 (2020) 637–648] by Varmazyari, Atefeh, Taghizadehghalehjoughi, Ali, Sevim, Cigdem, Baris, Ozlem, Eser, Gizem, Yildirim, Serkan, Hacimuftuoglu, Ahmet, Buha, Aleksandra, Wallace, David R., Tsatsakis, Aristidis, Aschner, Michael, Mezhuev, Yaroslav

“…[This corrects the article DOI: 10.1016/j.toxrep.2020.04.011.]…”
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Acute glufosinate-based herbicide treatment in rats leads to increased ocular interleukin-1β and c-Fos protein levels, as well as intraocular pressure by Çomaklı, Selim, Sevim, Çiğdem, Kontadakis, George, Doğan, Elif, Taghizadehghalehjoughi, Ali, Özkaraca, Mustafa, Aschner, Michael, Nikolouzakis, Taxiarchis Konstantinos, Tsatsakis, Aristides

“…[Display omitted] •Acute glufosinate-based herbicide (120 μM) treatment induced optic nerve damage.•There is a link between exposure to glufosinate and…”
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Identification of discriminative gene-level and protein-level features associated with pathogenic gain-of-function and loss-of-function variants by Sevim Bayrak, Cigdem, Stein, David, Jain, Aayushee, Chaudhary, Kumardeep, Nadkarni, Girish N., Van Vleck, Tielman T., Puel, Anne, Boisson-Dupuis, Stephanie, Okada, Satoshi, Stenson, Peter D., Cooper, David N., Schlessinger, Avner, Itan, Yuval

“…Identifying whether a given genetic mutation results in a gene product with increased (gain-of-function; GOF) or diminished (loss-of-function; LOF) activity is…”
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Patient subtyping analysis of baseline multi-omic data reveals distinct pre-immune states associated with antibody response to seasonal influenza vaccination by Sevim Bayrak, Cigdem, Forst, Christian V., Jones, Drew R., Gresham, David J., Pushalkar, Smruti, Wu, Shaohuan, Vogel, Christine, Mahal, Lara K., Ghedin, Elodie, Ross, Ted, García-Sastre, Adolfo, Zhang, Bin

“…Understanding the molecular mechanisms underpinning diverse vaccination responses is critical for developing efficient vaccines. Molecular subtyping can offer…”
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Investigation of the Effects of Probiotics on Sub-Chronic Neonicotinoid Toxicity in Rats by Sevim, Cigdem, Akpinar, Erol, Tsatsakis, Aristides, Yildirim, Serkan, Tzatzarakis, Manolis, Vardavas, Alexander I., Vardavas, Constantine I., Kara, Mehtap, Gul, Zulfiye

“…Probiotics have been shown to have positive effects when it comes to combating various health issues when consumed, preventing even the absorption of…”
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Protective effect of CDP-choline on hypotension and tissue injury in septic shock model by Sevim,Çiğdem, Altınbaş,Burçin, Yalçın,Murat, Özyiğit,Musa Özgür, Arıcan,İlker, Yılmaz,Mustafa Sertaç

“…CDP-choline is an endogen molecule and also a drug that is used in several trauma and ischemic conditions. It has been demonstrated that it improves the…”
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