Search Results - "Sevilla, Lisa M."

Roles of the Glucocorticoid and Mineralocorticoid Receptors in Skin Pathophysiology by Sevilla, Lisa M, Pérez, Paloma

“…The nuclear hormone receptor (NR) superfamily comprises approximately 50 evolutionarily conserved proteins that play major roles in gene regulation by…”
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Glucocorticoids and Glucocorticoid-Induced-Leucine-Zipper (GILZ) in Psoriasis by Sevilla, Lisa M, Pérez, Paloma

“…Psoriasis is a prevalent chronic inflammatory human disease initiated by impaired function of immune cells and epidermal keratinocytes, resulting in increased…”
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Glucocorticoid Resistance: Interference between the Glucocorticoid Receptor and the MAPK Signalling Pathways by Sevilla, Lisa M., Jiménez-Panizo, Alba, Alegre-Martí, Andrea, Estébanez-Perpiñá, Eva, Caelles, Carme, Pérez, Paloma

“…Endogenous glucocorticoids (GCs) are steroid hormones that signal in virtually all cell types to modulate tissue homeostasis throughout life. Also, synthetic…”
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Glucocorticoid receptor controls atopic dermatitis inflammation via functional interactions with P63 and autocrine signaling in epidermal keratinocytes by Sevilla, Lisa M., Pons-Alonso, Omar, Gallego, Andrea, Azkargorta, Mikel, Elortza, Félix, Pérez, Paloma

“…Atopic dermatitis (AD), a prevalent chronic inflammatory disease with multifactorial etiology, features epidermal barrier defects and immune overactivation…”
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Epidermal Inactivation of the Glucocorticoid Receptor Triggers Skin Barrier Defects and Cutaneous Inflammation by Sevilla, Lisa M., Latorre, Víctor, Sanchis, Ana, Pérez, Paloma

“…The glucocorticoid (GC) receptor (GR) mediates the effects of physiological and pharmacological GC ligands and has a major role in cutaneous pathophysiology…”
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Glucocorticoid receptor and Klf4 co-regulate anti-inflammatory genes in keratinocytes by Sevilla, Lisa M., Latorre, Víctor, Carceller, Elena, Boix, Julia, Vodák, Daniel, Mills, Ian Geoffrey, Pérez, Paloma

“…•GR ChIP-Seq identified primary targets in GC-treated mouse primary keratinocytes.•Binding motifs for GR and Klf4 were over represented in GR ChIP-seq…”
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Primary aldosteronism patients show skin alterations and abnormal activation of glucocorticoid receptor in keratinocytes by Boix, Julia, Bigas, Judit, Sevilla, Lisa M., Iacobone, Maurizio, Citton, Marilisa, Torresan, Francesca, Caroccia, Brasilina, Rossi, Gian Paolo, Pérez, Paloma

“…Primary aldosteronism (PA) is a disease characterized by high aldosterone levels caused by benign adrenal tumors being the most frequent cause of secondary…”
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Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier by Sevilla, Lisa M, Nachat, Rachida, Groot, Karen R, Klement, John F, Uitto, Jouni, Djian, Philippe, Määttä, Arto, Watt, Fiona M

“…The cornified envelope is assembled from transglutaminase cross-linked proteins and lipids in the outermost epidermal layers and is essential for skin barrier…”
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Selective Ablation of Glucocorticoid Receptor in Mouse Keratinocytes Increases Susceptibility to Skin Tumorigenesis by Latorre, Víctor, Sevilla, Lisa M., Sanchis, Ana, Pérez, Paloma

“…We recently demonstrated that mice lacking the epidermal glucocorticoid (GC) receptor (GR) (GR epidermal knockout (GREKO) mice) have developmental defects and…”
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Keratinocyte-targeted overexpression of the glucocorticoid receptor delays cutaneous wound healing by Sanchis, Ana, Alba, Lorena, Latorre, Víctor, Sevilla, Lisa M, Pérez, Paloma

“…Delayed wound healing is one of the most common secondary adverse effects associated to the therapeutic use of glucocorticoid (GC) analogs, which act through…”
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Kazrin regulates keratinocyte cytoskeletal networks, intercellular junctions and differentiation by Sevilla, Lisa M, Nachat, Rachida, Groot, Karen R, Watt, Fiona M

“…Kazrin is an evolutionarily conserved protein that is upregulated during keratinocyte terminal differentiation. Kazrin localizes to desmosomes and binds the…”
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Epidermal glucocorticoid and mineralocorticoid receptors act cooperatively to regulate epidermal development and counteract skin inflammation by Bigas, Judit, Sevilla, Lisa M., Carceller, Elena, Boix, Julia, Pérez, Paloma

“…Endogenous and synthetic glucocorticoids (GCs) regulate epidermal development and combat skin inflammatory diseases. GC actions can be mediated through the GC…”
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Epidermal Mineralocorticoid Receptor Inactivation Affects the Homeostasis of All Skin Layers in Chronologically Aged Mice by Bigas, Judit, Sevilla, Lisa M., Pérez, Paloma

“…The increased production of endogenous glucocorticoids (GCs) in the skin of the elderly population contributes to age-related defects strikingly similar to…”
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Epidermal Mineralocorticoid Receptor Plays Beneficial and Adverse Effects in Skin and Mediates Glucocorticoid Responses by Boix, Julia, Sevilla, Lisa M., Sáez, Zara, Carceller, Elena, Pérez, Paloma

“…Glucocorticoids (GCs) regulate skin homeostasis and combat cutaneous inflammatory diseases; however, adverse effects of chronic GC treatments limit their…”
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The mineralocorticoid receptor modulates timing and location of genomic binding by glucocorticoid receptor in response to synthetic glucocorticoids in keratinocytes by Carceller‐Zazo, Elena, Sevilla, Lisa M., Pons‐Alonso, Omar, Chiner‐Oms, Álvaro, Amazit, Larbi, An Vu, Thi, Vitellius, Géraldine, Viengchareun, Say, Comas, Iñaki, Jaszczyszyn, Yan, Abella, Montserrat, Alegre‐Martí, Andrea, Estébanez‐Perpiñá, Eva, Lombès, Marc, Pérez, Paloma

“…Glucocorticoids (GCs) exert potent antiproliferative and anti‐inflammatory properties, explaining their therapeutic efficacy for skin diseases. GCs act by…”
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Glucocorticoid-dependent transcription in skin requires epidermal expression of the glucocorticoid receptor and is modulated by the mineralocorticoid receptor by Sevilla, Lisa M., Bigas, Judit, Chiner-Oms, Álvaro, Comas, Iñaki, Sentandreu, Vicente, Pérez, Paloma

“…Glucocorticoid (GC) actions are mediated through two closely related ligand-dependent transcription factors, the GC receptor (GR) and the mineralocorticoid…”
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The mineralocorticoid receptor plays a transient role in mouse skin development by Boix, Julia, Carceller, Elena, Sevilla, Lisa M., Marcos-Garcés, Víctor, Pérez, Paloma

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KazrinE is a desmosome-associated liprin that colocalises with acetylated microtubules by Nachat, Rachida, Cipolat, Sara, Sevilla, Lisa M, Chhatriwala, Mariya, Groot, Karen R, Watt, Fiona M

“…Kazrin is a widely expressed, evolutionarily conserved cytoplasmic protein that binds the cytolinker protein periplakin. Multiple functions of kazrin have been…”
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Glucocorticoid Receptor Regulates Overlapping and Differential Gene Subsets in Developing and Adult Skin by Sevilla, Lisa M, Bayo, Pilar, Latorre, Víctor, Sanchis, Ana, Pérez, Paloma

“…We have previously shown that the glucocorticoid receptor (GR) is required for skin homeostasis and epidermal barrier competence. To understand the…”
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Exons 5–15 of Kazrin Are Dispensable for Murine Epidermal Morphogenesis and Homeostasis by Chhatriwala, Mariya K., Cipolat, Sara, Sevilla, Lisa M., Nachat, Rachida, Watt, Fiona M.

“…Kazrin binds to periplakin and ARVCF catenin, and regulates adhesion and differentiation of cultured human keratinocytes. To explore kazrin function in vivo,…”
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