Search Results - "Sevigny, Mary B."

Poly(ADP-ribose) Glycohydrolase Mediates Oxidative and Excitotoxic Neuronal Death by Ying, Weihai, Sevigny, Mary B., Chen, Yongmei, Swanson, Raymond A.

“…Excessive activation of poly(ADP-ribose) polymerase 1 (PARP1) leads to NAD+depletion and cell death during ischemia and other conditions that generate…”
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Acute and chronic cadmium exposure promotes E-cadherin degradation in MCF7 breast cancer cells by Ponce, Esmeralda, Louie, Maggie C., Sevigny, Mary B.

“…Cadmium is an environmental carcinogen that usually enters the body at minute concentrations through diet or cigarette smoke and bioaccumulates in soft…”
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Steroid hormone receptors as prognostic markers in breast cancer by Louie, Maggie C, Sevigny, Mary B

“…Despite the existence of many promising anti-cancer therapies, not all breast cancers are equally treatable, due partly to the fact that focus has been…”
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Novel flexible heteroarotinoid, SL-1-39, inhibits HER2-positive breast cancer cell proliferation by promoting lysosomal degradation of HER2 by Zou, Hongye, Sevigny, Mary B., Liu, Shengquan, Madden, David T., Louie, Maggie C.

“…SL-1-39 [1-(4-chloro-3-methylphenyl)-3-(4-nitrophenyl)thiourea] is a new flexible heteroarotinoid (Flex-Het) analog derived from the parental compound, SHetA2,…”
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Enantiomer of the novel flexible heteroarotinoid, SL-1-09, blocks cell cycle progression in breast cancer cells by Ginn, Emily, Baek, Jihyun, Zou, Hongye, Fallatah, Maryam M.J., Liu, Shengquan, Sevigny, Mary B., Louie, Maggie

“…Flexible heteroarotinoids (Flex-Hets) are compounds with promising anti-cancer activities. SHetA2, a first-generation Flex-Het, has been shown to inhibit the…”
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Novel flexible heteroarotinoid, SL-1-18, promotes ERα degradation to inhibit breast cancer cell growth by Fallatah, Maryam M., Liu, Shengquan, Sevigny, Mary B., Zou, Hongye, Louie, Maggie C.

“…SL-1-18 (1-(chrysen-6-yl)-3-(4-nitrophenyl)thiourea) is new flexible heteroarotinoid (Flex-Het) analog derived from the parent compound, SHetA2, and our…”
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Antibacterial activity of native California medicinal plant extracts isolated from Rhamnus californica and Umbellularia californica by Carranza, Maria G, Sevigny, Mary B, Banerjee, Debashree, Fox-Cubley, Lacie

“…Antimicrobial resistance (AMR) is a major threat to global public health. Medicinal plants have long been used as remedies for infectious diseases by native…”
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Glycosylation of human cyclooxygenase-2 (COX-2) decreases the efficacy of certain COX-2 inhibitors by Sevigny, Mary B., Graham, Kamara, Ponce, Esmeralda, Louie, Maggie C., Mitchell, Kylie

“…Prostanoids play an important role in a variety of physiological and pathophysiological processes including inflammation and cancer. The rate-limiting step in…”
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Glycosylation regulates turnover of cyclooxygenase-2 by Sevigny, Mary B., Li, Chai-Fei, Alas, Monika, Hughes-Fulford, Millie

“…Cyclooxygenase-2 (COX-2) catalyzes the rate-limiting step in the prostanoid biosynthesis pathway, converting arachidonic acid into prostaglandin H 2. COX-2…”
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Role of Cadmium and Nickel in Estrogen Receptor Signaling and Breast Cancer: Metalloestrogens or Not? by AQUINO, NATALIE B, SEVIGNY, MARY B, SABANGAN, JACKIELYN, LOUIE, MAGGIE C

“…During the past half-century, incidences of breast cancer have increased globally. Various factors—genetic and environmental—have been implicated in the…”
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Expression and activity of poly(ADP-ribose) glycohydrolase in cultured astrocytes, neurons, and C6 glioma cells by Sevigny, Mary B, Silva, Jillian M, Lan, Wen-Chun, Alano, Conrad C, Swanson, Raymond A

“…Poly(ADP-ribose) metabolism plays a major role in DNA repair, transcription, replication, and recombination. Poly(ADP-ribose) polymerases are localized…”
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Effect of glycosylation of cyclooxygenase‐2 (COX‐2) on homodimerization by Vann‐Victorino, Daniel DeWayne Colbert, Cunanan, Jelaine, Chen, Mindy, Chan, Rena, Hall, Randall W., Sevigny, Mary B.

“…Abstract only Prostaglandins are a group of fatty acid cell signals made from arachidonic acid. The prostaglandins have many roles in the body including…”
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The Role of Glycosylation in the Efficacy of Cyclooxygenase‐2 Inhibitors by Graham, Kamara Whitney, Sevigny, Mary B

“…Cyclooxygenase‐2 (COX‐2) is an enzyme that catalyzes the rate‐limiting step in the prostanoid synthesis pathway, which plays an important role in a variety of…”
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Glycosylation of cyclooxygenase‐2 (COX‐2) influences effectiveness of COX‐2 inhibitors by Graham, Kamara Whitney, Sevigny, Mary B., Gabriel, Bianca S

“…Abstract only Cyclooxygenase‐2 (COX‐2) is an enzyme that catalyzes the rate‐limiting step in the prostanoid synthesis pathway, which plays an important role in…”
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Differential glycosylation regulates turnover of cyclooxygenase‐2 by Sevigny, Mary B., Hughes‐Fulford, Millie

“…Cyclooxygenase‐2 (COX‐2) converts arachidonic acid (AA) into prostaglandin H2 and thus plays a key role in various physiological and pathophysiological…”
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Developmental expression and characterization of the α2,8-polysialyltransferase activity in embryonic chick brain by Sevigny, Mary B., Ye, Jean, Kitazume-Kawaguchi, Shinobu, Troy, Frederic A.

“…The α2,8-polysialyltransferases (polySTs) from embryonic chick brain catalyze the α2,8-specific polysialylation of endogenous neural cell adhesion molecules…”
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Heat shock - induced Hsp70 expression in murine astrocytes does not require poly(ADP-ribose) polymerase activity by Sevigny, Mary, Garnier, Philippe, Kauppinen, Tiina, Swanson, Raymond

“…Poly(ADP-ribose) polymerase (PARP) activity is involved in DNA repair, replication, recombination, and transcription. Extensive activation of the most abundant…”
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