Search Results - "Severina, I. S."

Role of soluble guanylate cyclase in the molecular mechanism underlying the physiological effects of nitric oxide by Severina, I S

“…In this review the molecular mechanisms underlying the antihypertensive and antiaggregatory actions of nitric oxide (NO) are discussed. It has been shown that…”
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Carnosine as a regulator of soluble guanylate cyclase by Severina, I S, Bussygina, O G, Pyatakova, N V

“…The molecular mechanism of the participation of carnosine in the functioning of soluble guanylate cyclase is discussed. It is shown that carnosine inhibits the…”
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YC-1-like potentiation of NO-dependent activation of soluble guanylate cyclase by derivatives of protoporphyrin IX by Severina, I S, Pyatakova, N V, Shchegolev, A Yu, Ponomarev, G V

“…The influence of protoporphyrin IX derivatives--2,4-di(1-methoxyethyl)-deuteroporphyrin IX disodium salt (dimegin) and hematoporphyrin IX (HP)--on the…”
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The history of renalase from amine oxidase to α-NAD(P)H-oxidase/anomerase by Severina, I. S., Fedchenko, V. I., Veselovsky, A. V., Medvedev, A. E.

“…Renalase is a recently discovered secretory protein, which plays a certain (still poorly understood) role in regulation of blood pressure. The review…”
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Nonselective inhibition of monoamine oxidases A and B by activators of soluble guanylate cyclase by Severina, I S, Axenova, L N, Veselovsky, A V, Pyatakova, N V, Buneeva, O A, Ivanov, A S, Medvedev, A E

“…Several activators of soluble guanylate cyclase were investigated as potential inhibitors of rat liver mitochondrial monoamine oxidases (MAO) A and B. They all…”
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Soluble guanylate cyclase in molecular mechanisms underlying the therapeutic action of drugs by Pyatakova, N. V., Severina, I. S.

“…The influence of ambroxol (a mucolytic agent) on the activity of human platelet soluble guanylate cyclase and rat lung soluble guanylate cyclase and activation…”
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Potentiation of NO-dependent activation of soluble guanylate cyclase by 5-nitroisatin and the antiviral agent arbidol by Severina, I. S., Schegolev, A. Yu, Medvedev, A. E.

“…Isatin (indole-dione-2,3) is an endogenous indole that exhibits a wide spectrum of biological and pharmacological activities. The effect of isatin derivatives,…”
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Derivatives of benzotetrazine-1,3-dioxide are new NO-donors, activators of soluble guanylate cyclase, and inhibitors of platelet aggregation by Pyatakova, N V, Khropov, Yu V, Churakov, A M, Tarasova, N I, Serezhenkov, V A, Vanin, A F, Tartakovsky, V A, Severina, I S

“…The ability of 5-nitro-, 7-nitro-, and 5,7-dinitrobenzotetrazine-1,3-dioxides to generate nitric oxide (NO) and activate soluble guanylate cyclase was…”
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Potentiation of activation of soluble guanylate cyclase by YC-1, NO-donors and increase of the synergistic effect of YC-1 on NO-dependent activation of the enzyme by 1,2,3-triazolyl-1,2,5-oxadiazole derivatives by Severina, I S, Pyatakova, N V, Shchegolev, A Yu, Rozhkov, V Yu, Batog, L V, Makhova, N N

“…The influence of (1H-1,2,3-triazol-1-yl)-1,2,5-oxadiazole derivatives: 4-amino-3-(5-methyl-4- ethoxycarbonyl-(1H-1,2,3-triazol-1-yl)-1,2,5-oxadiazole (TF4CH3)…”
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Potentiation of YC-1 activation of soluble guanylate cyclase by NO donors and the increase of the synergistic effect of YC-1 on the NO-dependent activation of the enzyme by 1,2,3-triazolyl-1,2,5-oxadiazole derivatives by Severina, I. S., Pyatakova, N. V., Shchegolev, A. Yu, Rozhkov, V. Yu, Batog, L. V., Makhova, N. N.

“…The influence of (1H-1,2,3-triazol-1-yl)-1,2,5-oxadiazole derivatives: 4-amino-3-(5-methyl-4-ethoxycarbonyl-(1H-1,2,3-triazol-1-yl)-1,2,5-oxadiazole (TF 4 CH 3…”
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Nitric oxide. Potentiation of NO-dependent activation of soluble guanylate cyclase: (Patho)physiological and pharmacotherapeutic importance by Severina, I. S.

“…The review highlights the molecular mechanism underlying the physiological effects of nitric oxide (NO), the role of signaling system: NO-soluble guanylate…”
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Inhibition of NO-dependent soluble human platelet guanylate cyclase by isatin by Severina, I. S., Schegolev, A. Yu, Ponomarev, G. V., Medvedev, A. E.

“…Isatin (indole-dione-2,3) is an endogenous indole that exhibits a wide spectrum of biological and pharmacological activities. Physiologically relevant…”
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Benzodifuroxan as an NO-dependent activator of soluble guanylate cyclase and a novel highly effective inhibitor of platelet aggregation by Bussygina, O G, Pyatakova, N V, Khropov, Y V, Ovchinnikov, I V, Makhova, N N, Severina, I S

“…The ability of benzodifuroxan (BDF) to activate human platelet guanylate cyclase was investigated. The maximal stimulatory effect (1160 +/- 86%) was observed…”
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Role of soluble guanylate cyclase in reactivation of choline esterase inhibited by phosphoorganic compounds by Pyatakova, N V, Grigoryev, N B, Severina, I S

“…The effects of possible activators of soluble guanylate cyclase were studied. Hydroxylamine and some oxime derivatives such as pyridinium aldoximes and…”
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Increase in reactivity of human platelet guanylate cyclase during aggregation potentiates the disaggregating capacity of sodium nitroprusside by Chirkov, Y Y, Belushkina, N N, Tyshchuk, I A, Severina, I S, Horowitz, J D

“…1. Basal and stimulated guanylate cyclase activity during ADP-induced human platelet aggregation in comparison with the actions of sodium nitroprusside (SNP)…”
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YC-1-like potentiation of nitric oxide-dependent activation of soluble guanylate cyclase by adrenochrom by Severina, I. S., Pyatakova, N. V., Shchegolev, A. Y., Sidorova, T. A.

“…The influence of adrenochrome and YC-1 activation of human platelet soluble guanylate cyclase was investigated. Adrenochrome (0.1–10.0 μM) had no effect on the…”
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Potentiation of NO-dependent activation of soluble guanylate cyclase by polyamines by Severina, I. S., Pyatakova, N. V., Shchegolev, A. Ya

“…The influence of polyamines (putrescine, spermidine, and spermine) on the activity of human platelet soluble guanylate cyclase and the stimulation of the…”
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Vasorelaxant and antiplatelet activity of 4,7‐dimethyl‐1,2,5‐oxadiazolo[3,4‐d]pyridazine 1,5,6‐trioxide: role of soluble guanylate cyclase, nitric oxide and thiols by Kots, Alexander Ya, Grafov, Mikhail A, Khropov, Yuri V, Betin, Vasily L, Belushkina, Natalya N, Busygina, Olga G, Yazykova, Marina Yu, Ovchinnikov, Igor V, Kulikov, Alexander S, Makhova, Nina N, Medvedeva, Natalya A, Bulargina, Tamara V, Severina, Irina S

“…Certain heterocyclic N‐oxides are vasodilators and inhibitors of platelet aggregation. The pharmacological activity of the furoxan derivative condensed with…”
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Guanylate cyclase in human platelets with different aggregability by Chirkov YuYu, Tyshchuk, I A, Severina, I S

“…The activity of human platelet guanylate cyclase, and the activation of the enzyme by sodium nitroprusside were decreased in platelets with increased…”
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Ambroxol as an inhibitor of nitric oxide-dependent activation of soluble guanylate cyclase by Severina, Irina S, Bussygina, Olga G, Pyatakova, Natalya V, Khropov, Yuri V, Krasnoperov, Renat A

“…The influence of ambroxol on the activity of human platelet soluble guanylate cyclase and rat lung soluble guanylate cyclase was investigated. Ambroxol in the…”
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