Search Results - "Severin, S E"

Telomerase as a tumor marker in diagnosis of prostatic intraepithelial neoplasia and prostate cancer by Glybochko, P.V., Zezerov, E.G., Glukhov, A.I., Alyaev, Yu.G., Severin, S.E., Polyakovsky, K.A., Varshavsky, V.A., Severin, E.S., Vinarov, A.Z.

“…BACKGROUND Early diagnosis of prostate cancer (CaP) can be addressed by studying prostatic intraepithelial neoplasia (PIN) as precancer (high‐grade PIN or…”
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Targeted delivery of anti-cancer growth inhibitory peptides derived from human α-fetoprotein: review of an International Multi-Center Collaborative Study by Mizejewski, GJ, Mirowski, M, Garnuszek, P, Maurin, M, Cohen, BD, Poiesz, BJ, Posypanova, GA, Makarov, VA, Severin, ES, Severin, SE

“…The α-fetoprotein derived growth inhibitory peptide (GIP) is a 34-amino acid peptide composed of three biologically active subfragments. GIP-34 and its three…”
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Toxicological studies of doxorubicin bound to polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles in healthy rats and rats with intracranial glioblastoma by Gelperina, S.E, Khalansky, A.S, Skidan, I.N, Smirnova, Z.S, Bobruskin, A.I, Severin, S.E, Turowski, B, Zanella, F.E, Kreuter, J

“…Polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles (NP) were shown to enable the transport of a number of drugs including the anti-tumour antibiotic…”
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Proliferative and Differentiation Potential of Multipotent Mesenchymal Stem Cells Cultured on Biocompatible Polymer Scaffolds with Various Physicochemical Characteristics by Rodina, A. V., Tenchurin, T. Kh, Saprykin, V. P., Shepelev, A. D., Mamagulashvili, V. G., Grigor’ev, T. E., Moskaleva, E. Yu, Chvalun, S. N., Severin, S. E.

“…Biocompatibility of film and fibrous scaffolds from polylactide-based polymers and the relationship between their architecture and the functional…”
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Targeted delivery of paclitaxel-loaded recombinant α-fetoprotein fragment-conjugated nanoparticles to tumor cells by Godovannyi, A. V., Vorontsov, E. A., Gukasova, N. V., Pozdnyakova, N. V., Vasilenko, E. A., Yabbarov, N. G., Dubovik, E. G., Severin, S. E., Severin, E. S., Gnuchev, N. V.

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Telomerase inhibitors as novel antitumor drugs by Glukhov, A. I, Svinareva, L. V, Severin, S. E, Shvets, V. I

“…Telomerase activity is detected in most types of human tumors, but it is almost undetectable in normal somatic cells; therefore, telomerase is a promising…”
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High-efficient renaturation of immobilized recombinant C-terminal fragment of human alpha-fetoprotein by Sharapova, O. A., Yurkova, M. S., Andronova, S. M., Fedorov, A. N., Severin, S. E., Severin, E. S.

“…C-terminal fragment of a human oncofetal alpha-fetoprotein (AFP) may be used in targeted cytostatics delivery to malignant cells of many tumors. AFP fragment…”
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The distribution of iodine-125 labeled alpha-fetoprotein in the animal organism and its accumulation in the tumor by Severin, S E, Kulakov, V N, Moskaleva, E Iu, Severin, E S, Slobodianik, I I, Klimova, T P

“…The distribution of iodine-125 labeled human alpha-fetoprotein in mice was studied after its intravenous injection. The maximal accumulation of…”
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Purification and characterization of recombinant human alpha-fetoprotein fragment, corresponding to the C-terminal structural domain by Sharapova, O A, Pozdniakova, N V, Laurinavichiute, D K, Iurkova, M S, Posypanova, G A, Andronova, S M, Fedorov, A N, Severin, S E, Severin, E S

“…Human alpha-fetoprotein (hAFP) is the main human oncofetal protein. Receptor of hAFP is expressed on the surface of different types of cancer cells, but not…”
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Isolation and characterization of the recombinant human α-fetoprotein fragment corresponding to the C-terminal structural domain by Sharapova, O. A, Pozdnyakova, N. V, Laurinavichyute, D. K, Yurkova, M. S, Posypanova, G. A, Andronova, S. M, Fedorov, A. N, Severin, S. E, Severin, E. S

“…Alpha-fetoprotein (AFP) is the major human oncofetal protein. The receptor of AFP is expressed by cells of various tumors and is not produced by normal cells…”
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A new system for targeted delivery of doxorubicin into tumor cells by Yabbarov, N.G., Posypanova, G.A., Vorontsov, E.A., Obydenny, S.I., Severin, E.S.

“…The use of vector molecules for the targeted delivery of antitumor drugs provides their selectivity for cancer cells. The recombinant receptor-binding fragment…”
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Inhibition of telomerase activity of melanoma cells in vitro by antisense oligonucleotides by Glukhov, A I, Zimnik, O V, Gordeev, S A, Severin, S E

“…The effect of antisense oligonucleotides complementary to the RNA component of human telomerase on telomerase activity in cell extracts of the melanoma cell…”
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Preparation and characterization of monoclonal antibodies to human adiponectin for its quantitative measurement in serum by Rodina, A. V., Gorokhovets, N. V., Makarov, V. A., Sologub, V. K., Koromyslova, I. A., Pozdniakova, L. P., Andreev, D. A., Ermakov, N. V., Severin, S. E.

“…Mouse Monoclonal antibodies against human adiponectin were produced by the routine method and the specificity of antibodies was verified. These monoclonal…”
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Functional characterization of recombinant human HSP70 domains and interdomain interactions by Chernikov, V. A., Gorokhovets, N. V., Savvateeva, L. V., Severin, S. E.

“…ATPase and peptide-binding activity of recombinant human heat shock proteins HSP70 A1B and HSC70 and two hybrid proteins derived from them was investigated…”
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Tumor angiogenesis inhibitors by Kiselev, S M, Lutsenko, S V, Severin, S E, Severin, E S

“…Formation of the blood supply system is a critical step in malignant transformation of neoplasms which results in the penetration of tumor cells into…”
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Regulation of the Physiological Functions of Human Dendritic Cells by Recombinant Heat Shock Protein Hsp70 by Paltsev, M. A., Severin, S. E., Danilevskii, M. I., Moskaleva, E. Yu

“…Dendritic cells (DC) are the most important antigen-presenting cells in the body. They are the target of action of various vaccines and dendritic cells have…”
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Targeted delivery of doxorubicin: Drug delivery system based on PAMAM dendrimers by Yabbarov, N. G., Posypanova, G. A., Vorontsov, E. A., Popova, O. N., Severin, E. S.

“…Polyamidoamine (PAMAM) dendrimers of the second generation (G2) are branched polymers containing 16 surface amino groups that allow them to be used as…”
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Formulation of perspective hepatoprotector polymeric forms based on silybin and ursodeoxycholic acid by Tereshchenko, O. G., Nikolskaya, E. D., Zhunina, O. A., Zavarzina, V. V., Yabbarov, N. G., Fomicheva, M. V., Zubkov, E. V., Sokol, M. B., Gukasova, N. V., Severin, E. S.

“…Silybin (Slb) and ursodeoxycholic acid (UDCA) are hepatoprotectors used in the pathogenetic therapy of liver and biliary tract. However, low bioavailability of…”
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The neuroleptic activity of haloperidol increases after its solubilization in surfactant micelles: Micelles as microcontainers for drug targeting by Kabanov, A.V., Chekhonin, V.P., Alakhov, V.Yu, Batrakova, E.V., Lebedev, A.S., Melik-Nubarov, N.S., Arzhakov, S.A., Levashov, A.V., Morozov, G.V., Severin, E.S., Kabanov, V.A.

“…It has been suggested to use surfactant micelles as microcontainers for increasing the efficiency of neuroleptic targeting from blood flow into the brain. The…”
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Polymer nanoparticles loaded with FeCl-tetraphenylporphyrin for binary catalytic therapy of neoplasms by Faustova, M. R., Nikolskaya, E. D., Zhunina, O. A., Mollaev, M. D., Yabbarov, N. G., Lobanov, A. V., Melnikov, M. Ya, Severin, E. S.

“…In order to study the possibility of using a metal complex of the porphyrin series, Fe III Cl-tetraphenylporphyrin (FeClTPP), and its polymeric form as…”
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