Search Results - "Severin, F. F."

Mild depolarization of the inner mitochondrial membrane is a crucial component of an anti-aging program by Vyssokikh, Mikhail Y., Holtze, Susanne, Averina, Olga A., Lyamzaev, Konstantin G., Panteleeva, Alisa A., Marey, Maria V., Zinovkin, Roman A., Severin, Fedor F., Skulachev, Maxim V., Fasel, Nicolas, Hildebrandt, Thomas B., Skulachev, Vladimir P.

“…The mitochondria of various tissues from mice, naked mole rats (NMRs), and bats possess two mechanistically similar systems to prevent the generation of…”
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Manipulating Cellular Energetics to Slow Aging of Tissues and Organs by Sokolov, S. S., Severin, F. F.

“…Up to now numerous studies in the field of gerontology have been published. Nevertheless, a well-known food restriction remains the most reliable and efficient…”
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Adaptive Role of Cell Death in Yeast Communities Stressed with Macrolide Antifungals by Kireeva, N A, Sokolov, S S, Smirnova, E A, Galkina, K V, Severin, F F, Knorre, D A

“…Microorganisms cooperate with each other to protect themselves from environmental stressors. An extreme case of such cooperation is regulated cell death for…”
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Role of mitochondria in the pheromone- and amiodarone-induced programmed death of yeast by Pozniakovsky, Andrei I, Knorre, Dmitry A, Markova, Olga V, Hyman, Anthony A, Skulachev, Vladimir P, Severin, Fedor F

“…Although programmed cell death (PCD) is extensively studied in multicellular organisms, in recent years it has been shown that a unicellular organism, yeast…”
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Mitochondrial-targeted plastoquinone derivatives. Effect on senescence and acute age-related pathologies by Skulachev, M V, Antonenko, Y N, Anisimov, V N, Chernyak, B V, Cherepanov, D A, Chistyakov, V A, Egorov, M V, Kolosova, N G, Korshunova, G A, Lyamzaev, K G, Plotnikov, E Y, Roginsky, V A, Savchenko, A Y, Severina, I I, Severin, F F, Shkurat, T P, Tashlitsky, V N, Shidlovsky, K M, Vyssokikh, M Y, Zamyatnin, Jr, A A, Zorov, D B, Skulachev, V P

“…Plastoquinone, a very effective electron carrier and antioxidant of chloroplasts, was conjugated with decyltriphenylphosphonium to obtain a cation easily…”
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Six Functions of Respiration: Isn’t It Time to Take Control over ROS Production in Mitochondria, and Aging Along with It? by Skulachev, Vladimir P, Vyssokikh, Mikhail Yu, Chernyak, Boris V, Mulkidjanian, Armen Y, Skulachev, Maxim V, Shilovsky, Gregory A, Lyamzaev, Konstantin G, Borisov, Vitaliy B, Severin, Fedor F, Sadovnichii, Victor A

“…Cellular respiration is associated with at least six distinct but intertwined biological functions. (1) biosynthesis of ATP from ADP and inorganic phosphate,…”
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Ergosterol Turnover in Yeast: An Interplay between Biosynthesis and Transport by Sokolov, S. S., Trushina, N. I., Severin, F. F., Knorre, D. A.

“…Sterols are important components of biological membranes that determine the physicochemical properties of lipid bilayer and regulate the functioning of…”
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Evolutionary Choice between Cholesterol and Ergosterol by Sokolov, S. S., Akimov, S. A., Severin, F. F.

“…Sterol biosynthesis has evolved early in the history of eukaryotes. In most animals, as well as in primitive fungi, the main sterol is cholesterol. During the…”
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Replicative aging as a source of cell heterogeneity in budding yeast by Knorre, Dmitry A., Azbarova, Aglaia V., Galkina, Kseniia V., Feniouk, Boris A., Severin, Fedor F.

“…•Sequential rounds of asymmetric division cause microbial heterogeneity.•Increased phenotypic variance can be beneficial under stressful conditions.•Microbial…”
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Mitochondrial depolarization in yeast zygotes inhibits clonal expansion of selfish mtDNA by Karavaeva, Iuliia E, Golyshev, Sergey A, Smirnova, Ekaterina A, Sokolov, Svyatoslav S, Severin, Fedor F, Knorre, Dmitry A

“…Non-identical copies of mitochondrial DNA (mtDNA) compete with each other within a cell and the ultimate variant of mtDNA present depends on their relative…”
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Mitochondrial Superoxide Dismutase and Yap1p Act as a Signaling Module Contributing to Ethanol Tolerance of the Yeast Saccharomyces cerevisiae by Zyrina, Anna N, Smirnova, Ekaterina A, Markova, Olga V, Severin, Fedor F, Knorre, Dmitry A

“…There are two superoxide dismutases in the yeast Saccharomyces cerevisiae-cytoplasmic and mitochondrial enzymes. Inactivation of the cytoplasmic enzyme, Sod1p,…”
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Penetrating cation/fatty acid anion pair as a mitochondria-targeted protonophore by Severin, Fedor F, Severina, Inna I, Antonenko, Yury N, Rokitskaya, Tatiana I, Cherepanov, Dmitry A, Mokhova, Elena N, Vyssokikh, Mikhail Yu, Pustovidko, Antonina V, Markova, Olga V, Yaguzhinsky, Lev S, Korshunova, Galina A, Sumbatyan, Nataliya V, Skulachev, Maxim V, Skulachev, Vladimir P

“…A unique phenomenon of mitochondria-targeted protonophores is described. It consists in a transmembrane H⁺-conducting fatty acid cycling mediated by…”
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Penetrating cations induce pleiotropic drug resistance in yeast by Galkina, Kseniia V., Besedina, Elizaveta G., Zinovkin, Roman A., Severin, Fedor F., Knorre, Dmitry A.

“…Substrates of pleiotropic drug resistance (PDR) transporters can induce the expression of corresponding transporter genes by binding to their transcription…”
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Structural Role of Plasma Membrane Sterols in Osmotic Stress Tolerance of Yeast Saccharomyces cerevisiae by Sokolov, Svyatoslav S, Popova, Marina M, Pohl, Peter, Horner, Andreas, Akimov, Sergey A, Kireeva, Natalia A, Knorre, Dmitry A, Batishchev, Oleg V, Severin, Fedor F

“…Yeast has been shown to suppress a sterol biosynthesis as a response to hyperosmotic stress. In the case of sodium stress, the failure to suppress biosynthesis…”
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The Membrane-Water Partition Coefficients of Antifungal, but Not Antibacterial, Membrane-Active Compounds Are Similar by Volynsky, Pavel E., Smirnova, Alexandra I., Akimov, Sergey A., Sokolov, Svyatoslav S., Severin, Fedor F.

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Pheromone Induces Programmed Cell Death in S. cerevisiae by Severin, F.F., Hyman, A.A.

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LAM Genes Contribute to Environmental Stress Tolerance but Sensibilize Yeast Cells to Azoles by Sokolov, Svyatoslav S, Vorobeva, Margarita A, Smirnova, Alexandra I, Smirnova, Ekaterina A, Trushina, Nataliya I, Galkina, Kseniia V, Severin, Fedor F, Knorre, Dmitry A

“…Lam proteins transport sterols between the membranes of different cellular compartments. In the gene family consists of three pairs of paralogs. Because the…”
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The Role of LAM Genes in the Pheromone-Induced Cell Death of S. cerevisiae Yeast by Sokolov, S. S., Galkina, K. V., Litvinova, E. A., Knorre, D. A., Severin, F. F.

“…Lam1–4 proteins perform non-vesicular transport of sterols from the plasma membrane to the endoplasmic reticulum. Disruption of their function leads to an…”
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Prevention of cardiolipin oxidation and fatty acid cycling as two antioxidant mechanisms of cationic derivatives of plastoquinone (SkQs) by Skulachev, Vladimir P., Antonenko, Yury N., Cherepanov, Dmitry A., Chernyak, Boris V., Izyumov, Denis S., Khailova, Ludmila S., Klishin, Sergey S., Korshunova, Galina A., Lyamzaev, Konstantin G., Pletjushkina, Olga Yu, Roginsky, Vitaly A., Rokitskaya, Tatiana I., Severin, Fedor F., Severina, Inna I., Simonyan, Ruben A., Skulachev, Maxim V., Sumbatyan, Natalia V., Sukhanova, Evgeniya I., Tashlitsky, Vadim N., Trendeleva, Tatyana A., Vyssokikh, Mikhail Yu, Zvyagilskaya, Renata A.

“…The present state of the art in studies on the mechanisms of antioxidant activities of mitochondria-targeted cationic plastoquinone derivatives (SkQs) is…”
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Uncouplers of oxidation and phosphorylation as antiaging compounds by Knorre, D. A., Severin, F. F.

“…Food restriction causes a set of physiological changes that reduce the rate of aging. At the level of an organism, these changes are initiated by a hormonal…”
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