Search Results - "Severgnini, Mariano"

Ipilimumab for Patients with Relapse after Allogeneic Transplantation by Davids, Matthew S, Kim, Haesook T, Bachireddy, Pavan, Costello, Caitlin, Liguori, Rebecca, Savell, Alexandra, Lukez, Alexander P, Avigan, David, Chen, Yi-Bin, McSweeney, Peter, LeBoeuf, Nicole R, Rooney, Michael S, Bowden, Michaela, Zhou, Chensheng W, Granter, Scott R, Hornick, Jason L, Rodig, Scott J, Hirakawa, Masahiro, Severgnini, Mariano, Hodi, F. Stephen, Wu, Catherine J, Ho, Vincent T, Cutler, Corey, Koreth, John, Alyea, Edwin P, Antin, Joseph H, Armand, Philippe, Streicher, Howard, Ball, Edward D, Ritz, Jerome, Bashey, Asad, Soiffer, Robert J

“…Hematologic cancers that recur after allogeneic hematopoietic stem-cell transplantation are often difficult to treat. A small pilot study suggests that…”
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Cytokine changes during immune-related adverse events and corticosteroid treatment in melanoma patients receiving immune checkpoint inhibitors by Tyan, Kevin, Baginska, Joanna, Brainard, Martha, Giobbie-Hurder, Anita, Severgnini, Mariano, Manos, Michael, Haq, Rizwan, Buchbinder, Elizabeth I., Ott, Patrick A., Hodi, F. Stephen, Rahma, Osama E.

“…Background Immune checkpoint inhibitors (ICIs) often cause immune-related adverse events (irAEs), most of which are treated with corticosteroids despite…”
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Plasma IL-6 changes correlate to PD-1 inhibitor responses in NSCLC by Keegan, Alissa, Ricciuti, Biagio, Garden, Padric, Cohen, Limor, Nishihara, Reiko, Adeni, Anika, Paweletz, Cloud, Supplee, Julianna, Jänne, Pasi A, Severgnini, Mariano, Awad, Mark M, Walt, David R

“…BackgroundBlood-based biomarkers of anti-solid tumor immune checkpoint blockade (ICB) response are lacking. We hypothesized that changes in systemic cytokine…”
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Clonal dynamics of alloreactive T cells in kidney allograft rejection after anti-PD-1 therapy by Dunlap, Garrett S., DiToro, Daniel, Henderson, Joel, Shah, Sujal I., Manos, Mike, Severgnini, Mariano, Weins, Astrid, Guleria, Indira, Ott, Patrick A., Murakami, Naoka, Rao, Deepak A.

“…Kidney transplant recipients are at particular risk for developing tumors, many of which are now routinely treated with immune checkpoint inhibitors (ICIs);…”
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Early plasma circulating tumor DNA (ctDNA) changes predict response to first-line pembrolizumab-based therapy in non-small cell lung cancer (NSCLC) by Ricciuti, Biagio, Jones, Greg, Severgnini, Mariano, Alessi, Joao V, Recondo, Gonzalo, Lawrence, Marissa, Forshew, Tim, Lydon, Christine, Nishino, Mizuki, Cheng, Michael, Awad, Mark

“…BackgroundCurrently available biomarkers are imperfect in their ability to predict responses to the multiple first-line treatment options available for…”
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Distinct predictive biomarker candidates for response to anti-CTLA-4 and anti-PD-1 immunotherapy in melanoma patients by Subrahmanyam, Priyanka B, Dong, Zhiwan, Gusenleitner, Daniel, Giobbie-Hurder, Anita, Severgnini, Mariano, Zhou, Jun, Manos, Michael, Eastman, Lauren M, Maecker, Holden T, Hodi, F Stephen

“…While immune checkpoint blockade has greatly improved clinical outcomes in diseases such as melanoma, there remains a need for predictive biomarkers to…”
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A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation by Lazarian, Gregory, Yin, Shanye, ten Hacken, Elisa, Sewastianik, Tomasz, Uduman, Mohamed, Font-Tello, Alba, Gohil, Satyen H., Li, Shuqiang, Kim, Ekaterina, Joyal, Heather, Billington, Leah, Witten, Elizabeth, Zheng, Mei, Huang, Teddy, Severgnini, Mariano, Lefebvre, Valerie, Rassenti, Laura Z., Gutierrez, Catherine, Georgopoulos, Katia, Ott, Christopher J., Wang, Lili, Kipps, Thomas J., Burger, Jan A., Livak, Kenneth J., Neuberg, Donna S., Baran-Marszak, Fanny, Cymbalista, Florence, Carrasco, Ruben D., Wu, Catherine J.

“…Hotspot mutation of IKZF3 (IKZF3-L162R) has been identified as a putative driver of chronic lymphocytic leukemia (CLL), but its function remains unknown. Here,…”
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Immune modulating activity of the CHK1 inhibitor prexasertib and anti-PD-L1 antibody LY3300054 in patients with high-grade serous ovarian cancer and other solid tumors by Do, Khanh T., Manuszak, Claire, Thrash, Emily, Giobbie-Hurder, Anita, Hu, Jiani, Kelland, Sarah, Powers, Allison, de Jonge, Adrienne, Shapiro, Geoffrey I., Severgnini, Mariano

“…Background Checkpoint kinase 1 (CHK1) has dual roles in both the DNA damage response and in the innate immune response to genotoxic stress. The combination of…”
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Pneumonitis resulting from radiation and immune checkpoint blockade illustrates characteristic clinical, radiologic and circulating biomarker features by Schoenfeld, Jonathan D, Nishino, Mizuki, Severgnini, Mariano, Manos, Michael, Mak, Raymond H, Hodi, F Stephen

“…Pneumonitis is a potential consequence of both lung-directed radiation and immune checkpoint blockade (ICB), particularly treatment with PD-1/PD-L1 inhibitors…”
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Molecular correlates of response to eribulin and pembrolizumab in hormone receptor-positive metastatic breast cancer by Keenan, Tanya E., Guerriero, Jennifer L., Barroso-Sousa, Romualdo, Li, Tianyu, O’Meara, Tess, Giobbie-Hurder, Anita, Tayob, Nabihah, Hu, Jiani, Severgnini, Mariano, Agudo, Judith, Vaz-Luis, Ines, Anderson, Leilani, Attaya, Victoria, Park, Jihye, Conway, Jake, He, Meng Xiao, Reardon, Brendan, Shannon, Erin, Wulf, Gerburg, Spring, Laura M., Jeselsohn, Rinath, Krop, Ian, Lin, Nancy U., Partridge, Ann, Winer, Eric P., Mittendorf, Elizabeth A., Liu, David, Van Allen, Eliezer M., Tolaney, Sara M.

“…Immune checkpoint inhibitors (ICIs) have minimal therapeutic effect in hormone receptor-positive (HR+ ) breast cancer. We present final overall survival (OS)…”
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Definitive chemoradiation alters the immunologic landscape and immune checkpoints in head and neck cancer by Sridharan, Vishwajith, Margalit, Danielle N, Lynch, Stephanie A, Severgnini, Mariano, Zhou, Jun, Chau, Nicole G, Rabinowits, Guilherme, Lorch, Jochen H, Hammerman, Peter S, Hodi, F Stephen, Haddad, Robert I, Tishler, Roy B, Schoenfeld, Jonathan D

“…Background: Preclinical and clinical studies suggest potential synergy between high dose per fraction focal radiation and immunotherapy. However,…”
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Angiopoietin-2 as a Biomarker and Target for Immune Checkpoint Therapy by Wu, Xinqi, Giobbie-Hurder, Anita, Liao, Xiaoyun, Connelly, Courtney, Connolly, Erin M, Li, Jingjing, Manos, Michael P, Lawrence, Donald, McDermott, David, Severgnini, Mariano, Zhou, Jun, Gjini, Evisa, Lako, Ana, Lipschitz, Mikel, Pak, Christine J, Abdelrahman, Sara, Rodig, Scott, Hodi, F Stephen

“…Immune checkpoint therapies targeting CTLA-4 and PD-1 have proven effective in cancer treatment. However, the identification of biomarkers for predicting…”
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Molecular and cellular features of CTLA-4 blockade for relapsed myeloid malignancies after transplantation by Penter, Livius, Zhang, Yi, Savell, Alexandra, Huang, Teddy, Cieri, Nicoletta, Thrash, Emily M., Kim-Schulze, Seunghee, Jhaveri, Aashna, Fu, Jingxin, Ranasinghe, Srinika, Li, Shuqiang, Zhang, Wandi, Hathaway, Emma S., Nazzaro, Matthew, Kim, Haesook T., Chen, Helen, Thurin, Magdalena, Rodig, Scott J., Severgnini, Mariano, Cibulskis, Carrie, Gabriel, Stacey, Livak, Kenneth J., Cutler, Corey, Antin, Joseph H., Nikiforow, Sarah, Koreth, John, Ho, Vincent T., Armand, Philippe, Ritz, Jerome, Streicher, Howard, Neuberg, Donna, Hodi, F. Stephen, Gnjatic, Sacha, Soiffer, Robert J., Liu, X. Shirley, Davids, Matthew S., Bachireddy, Pavan, Wu, Catherine J.

“…Relapsed myeloid disease after allogeneic stem cell transplantation (HSCT) remains largely incurable. We previously demonstrated the potent activity of immune…”
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A rapid two-step method for isolation of functional primary mouse hepatocytes: cell characterization and asialoglycoprotein receptor based assay development by Severgnini, Mariano, Sherman, Jennifer, Sehgal, Alfica, Jayaprakash, Narayanannair K., Aubin, Justin, Wang, Gang, Zhang, Ligang, Peng, Chang G., Yucius, Kristina, Butler, Jim, Fitzgerald, Kevin

“…Primary mouse hepatocytes are an important tool in the biomedical research field for the assessment of hepatocyte function. Several methods for hepatocyte…”
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Phase II trial of vaccination with autologous, irradiated melanoma cells engineered by adenoviral mediated gene transfer to secrete granulocyte-macrophage colony stimulating factor in patients with stage III and IV melanoma by Sussman, Tamara A, Severgnini, Mariano, Giobbie-Hurder, Anita, Friedlander, Philip, Swanson, Scott J, Jaklitsch, Michael, Clancy, Thomas, Goguen, Laura A, Lautz, David, Swanson, Richard, Daley, Heather, Ritz, Jerome, Dranoff, Glenn, Hodi, F Stephen

“…In the era of immune checkpoint blockade, the role of cancer vaccines in immune priming has provided additional potential for therapeutic improvements. Prior…”
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Anti-CTLA-4 based therapy elicits humoral immunity to galectin-3 in patients with metastatic melanoma by Wu, Xinqi, Giobbie-Hurder, Anita, Connolly, Erin M., Li, Jingjing, Liao, Xiaoyun, Severgnini, Mariano, Zhou, Jun, Rodig, Scott, Hodi, F. Stephen

“…The combination of CTLA-4 blockade ipilimumab (Ipi) with VEGF-A blocking antibody bevacizumab (Bev) has demonstrated favorable clinical outcomes in patients…”
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Anti‐PD‐1 Immunotherapy‐Induced Flare of a Known Underlying Relapsing Vasculitis Mimicking Recurrent Cancer by Nabel, Christopher S., Severgnini, Mariano, Hung, Yin P., Cunningham‐Bussel, Amy, Gjini, Evisa, Kleinsteuber, Katja, Seymour, Lake J., Holland, Martha K., Cunningham, Rachel, Felt, Kristin D., Vivero, Marina, Rodig, Scott J., Massarotti, Elena M., Rahma, Osama E., Harshman, Lauren C.

“…Safe use of immune checkpoint blockade in patients with cancer and autoimmune disorders requires a better understanding of the pathophysiology of immunologic…”
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Development of an 8-color antibody panel for functional phenotyping of human CD8+ cytotoxic T cells from peripheral blood mononuclear cells by Patel, Tara, Cunningham, Amy, Holland, Martha, Daley, John, Lazo, Suzan, Hodi, F. Stephen, Severgnini, Mariano

“…The study of CD8 positive cells in peripheral blood has become an essential part of research in the field of cancer immunotherapies, vaccine development,…”
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Phase IB study of ziv-aflibercept plus pembrolizumab in patients with advanced solid tumors by Rahma, Osama E, Tyan, Kevin, Giobbie-Hurder, Anita, Brohl, Andrew S, Bedard, Philippe L, Renouf, Daniel J, Sharon, Elad, Streicher, Howard, Hathaway, Emma, Cunningham, Rachel, Manos, Michael, Severgnini, Mariano, Rodig, Scott, Stephen Hodi, F

“…BackgroundThe combination of antiangiogenic agents with immune checkpoint inhibitors could potentially overcome immune suppression driven by tumor…”
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Airway Epithelial STAT3 Is Required for Allergic Inflammation in a Murine Model of Asthma by Simeone-Penney, Marina C, Severgnini, Mariano, Tu, Powen, Homer, Robert J, Mariani, Thomas J, Cohn, Lauren, Simon, Amy R

“…The STAT3 transcription factor is critical for cytokine signaling and the acute phase response, but its role in allergic asthma is largely undefined. To…”
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