Search Results - "Sevarino, Kevin A."

Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits by Lipton, Stuart A, Zhang, Dongxian, Chatterton, Jon E, Awobuluyi, Marc, Premkumar, Louis S, Takahashi, Hiroto, Talantova, Maria, Shin, Yeonsook, Cui, Jiankun, Tu, Shichun, Sevarino, Kevin A, Nakanishi, Nobuki, Tong, Gang

“…The N-methyl-d-aspartate subtype of glutamate receptor (NMDAR) serves critical functions in physiological and pathological processes in the central nervous…”
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The thyrotropin-releasing hormone (TRH) hypothesis of homeostatic regulation: implications for TRH-based therapeutics by Gary, Keith A, Sevarino, Kevin A, Yarbrough, George G, Prange, Jr, Arthur J, Winokur, Andrew

“…The functions of thyrotropin-releasing hormone (TRH) in the central nervous system (CNS) can be conceptualized as performed by four anatomically distinct…”
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Concurrent Alcohol and Tobacco Treatment: Effect on Daily Process Measures of Alcohol Relapse Risk by Cooney, Ned L., Litt, Mark D., Sevarino, Kevin A., Levy, Lucienne, Kranitz, Linda S., Sackler, Helen, Cooney, Judith L.

“…Objective: The aim of this study was to compare the effects of alcohol treatment along with concurrent smoking treatment or delayed smoking treatment on…”
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Mecamylamine treatment for alcohol dependence: a randomized controlled trial by Petrakis, Ismene L., Ralevski, Elizabeth, Gueorguieva, Ralitza, O'Malley, Stephanie S., Arias, Albert, Sevarino, Kevin A., Jane, Jane S., O'Brien, Erin, Krystal, John H.

“…Background and aims The nicotinic acetylcholine receptor antagonist, mecamylamine, is a potential novel pharmacotherapy for alcohol use disorder. The aims were…”
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Efficacy of dose and contingency management procedures in LAAM-maintained cocaine-dependent patients by Oliveto, Alison, Poling, James, Sevarino, Kevin A., Gonsai, Kishorchandra R., McCance-Katz, Elinore F., Stine, Susan M., Kosten, Thomas R.

“…Opioid- and cocaine-dependent participants ( N = 140) were randomly assigned to one of the following in a 12-week clinical trial: LAAM (30, 30, 39 mg/MWF) with…”
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A general role for adaptations in G-proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function by Terwilliger, R Z, Beitner-Johnson, D, Sevarino, K A, Crain, S M, Nestler, E J

“…Previous studies have shown that chronic morphine increases levels of the G-protein subunits Gia and Goa, adenylate cyclase, cyclic AMP-dependent protein…”
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Ketoconazole increases cocaine and opioid use in methadone maintained patients by Kosten, Thomas R., Oliveto, Alison, Sevarino, Kevin A., Gonsai, Kishor, Feingold, Alan

“…Stress plays an important role in substance abuse problems. For example, in studies with rodents stress induces reinstatement of opioid and cocaine…”
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Management of psychiatric issues in patients with intellectual disability by Trestman, Robert L, Sevarino, Kevin A, Kelly, Martin

“…The psychiatric treatment of people with intellectual disability and mental illness has progressed substantially. Not only have our interventions improved, the…”
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The Biology of pro-Thyrotropin-Releasing Hormone-Derived Peptides by Nillni, Eduardo A., Sevarino, Kevin A.

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An anti- χ-1 antibody recognizes a heavily glycosylated protein in rat brain by Ciabarra, Anthony M, Sevarino, Kevin A

“…The χ-1 subunit is a recently identified member of a new class of the ionotropic glutamate receptor family that attenuates NMDA receptor current. We have…”
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Cloning and characterization of chi-1: a developmentally regulated member of a novel class of the ionotropic glutamate receptor family by Ciabarra, AM, Sullivan, JM, Gahn, LG, Pecht, G, Heinemann, S, Sevarino, KA

“…Ionotropic glutamate receptors are composed of homomeric or heteromeric configurations of glutamate receptor subunits. We have cloned a member of a novel class…”
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Comparison of intravenous cocaethylene and cocaine in humans by HART, C. L, JATLOW, P, SEVARINO, K. A, MCCANCE-KATZ, E. F

“…Cocaethylene is a pharmacologically active homolog and metabolite of cocaine, formed by transesterification of cocaine in the presence of ethanol. Here we…”
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The Biology of pro-Thyrotropin-Releasing Hormone-Derived Peptides1 by Nillni, Eduardo A, Sevarino, Kevin A

“…I. Introduction II. Biosynthesis of TRH and Other pro-TRH-Derived Peptides A. Biosynthesis and processing of pro-TRH B. Intracellular sites of pro-TRH…”
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Identification of a Cyclic-AMP-Responsive Element within the Rat Somatostatin Gene by Montminy, Marc R., Sevarino, Kevin A., Wagner, John A., Mandel, Gail, Goodman, Richard H.

“…We have examined the regulation of somatostatin gene expression by cAMP in PC12 rat pheochromocytoma cells transfected with the rat somatostatin gene…”
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Chronic cocaine treatment decreases levels of the G protein subunits Gi alpha and Go alpha in discrete regions of rat brain by Nestler, E J, Terwilliger, R Z, Walker, J R, Sevarino, K A, Duman, R S

“…A possible role for G proteins in contributing to the chronic actions of cocaine was investigated in three rat brain regions known to exhibit…”
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Neurobiological Adaptations to Psychostimulants and Opiates as a Basis of Treatment Development by SEVARINO, KEVIN A., OLIVETO, ALISON, KOSTEN, THOMAS R.

“…: Abuse of illicit substances, in particular psychostimulants and opiates, is a worldwide public health issue. Chronic use of cocaine and amphetamine causes…”
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Cytochrome-c oxidase from Saccharomyces cerevisiae by Poyton, R O, Goehring, B, Droste, M, Sevarino, K A, Allen, L A, Zhao, X J

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Processing of proTRH to its intermediate products occurs before the packing into secretory granules of transfected AtT20 cells by Nillni, E A, Sevarino, K A, Jackson, I M

“…The intracellular compartments where posttranslational processing of proTRH takes place have not been identified. Using AtT20 cells transfected with a…”
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Amino-terminal sequences of prosomatostatin direct intracellular targeting but not processing specificity by Sevarino, K A, Stork, P, Ventimiglia, R, Mandel, G, Goodman, R H

“…Rat preprosomatostatin (rPPSS) is processed to two bioactive peptides, somatostatin-14 and somatostatin-28. In anglerfish islets, the two peptides are…”
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Identification of the thyrotropin-releasing hormone-prohormone and its posttranslational processing in a transfected AtT20 tumoral cell line by Nillni, E A, Sevarino, K A, Jackson, I M

“…By using an AtT20 cell line transfected with complementary DNA for preproTRH, we have identified the proTRH polyeptide precursor [26 kilodaltons (kDa)] and…”
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