Search Results - "Seungyeon Yang"

Mitochondrial GPT2 plays a pivotal role in metabolic adaptation to the perturbation of mitochondrial glutamine metabolism by Kim, Minjoong, Gwak, Jihye, Hwang, Sunsook, Yang, Seungyeon, Jeong, Seung Min

“…Cancer cells exhibit metabolic dependence on mitochondrial glutamine metabolism that provides them with the substrates required for rapid proliferation…”
Get full text

Fatty acid oxidation facilitates DNA double-strand break repair by promoting PARP1 acetylation by Yang, Seungyeon, Hwang, Sunsook, Kim, Byungjoo, Shin, Seungmin, Kim, Minjoong, Jeong, Seung Min

“…DNA repair is a tightly coordinated stress response to DNA damage, which is critical for preserving genome integrity. Accruing evidence suggests that metabolic…”
Get full text

Fatty acid oxidation regulates cellular senescence by modulating the autophagy-SIRT1 axis by Seungyeon Yang, Subin Moon, Soojung Claire Hur, Seung Min Jeong

“…Senescence, a cellular process through which damaged or dysfunctional cells suppress the cell cycle, contributes to aging or age-related functional decline…”
Get full text

Mitochondrial glutamine metabolism regulates sensitivity of cancer cells after chemotherapy via amphiregulin by Hwang, Sunsook, Yang, Seungyeon, Kim, Minjoong, Hong, Youlim, Kim, Byungjoo, Lee, Eun Kyung, Jeong, Seung Min

“…The DNA damage response is essential for sustaining genomic stability and preventing tumorigenesis. However, the fundamental question about the cellular…”
Get full text

Induction of Fatty Acid Oxidation Underlies DNA Damage‐Induced Cell Death and Ameliorates Obesity‐Driven Chemoresistance by Hwang, Sunsook, Yang, Seungyeon, Park, Kyungsoo, Kim, Byungjoo, Kim, Minjoong, Shin, Seungmin, Yoo, Ahyoung, Ahn, Jiyun, Jang, Juneil, Yim, Yeong Shin, Seong, Rho H., Jeong, Seung Min

“…The DNA damage response is essential for preserving genome integrity and eliminating damaged cells. Although cellular metabolism plays a central role in cell…”
Get full text

YAP governs cellular adaptation to perturbation of glutamine metabolism by regulating ATF4-mediated stress response by Kim, Minjoong, Hwang, Sunsook, Kim, Byungjoo, Shin, Seungmin, Yang, Seungyeon, Gwak, Jihye, Jeong, Seung Min

“…Proliferating cells have metabolic dependence on glutamine to fuel anabolic pathways and to refill the mitochondrial carbon pool. The Hippo pathway is…”
Get full text

Fatty acid oxidation supports melanoma cell migration through autophagy regulation by Shin, Seungmin, Yang, Seungyeon, Kim, Minjoong, Lee, Eun Kyung, Hur, Soojung Claire, Jeong, Seung Min

“…Metastasis is one of the most malignant characteristics of cancer cells, in which metabolic reprogramming is crucial for promoting and sustaining multi-steps…”
Get full text

Fatty acid oxidation regulates cellular senescence by modulating the autophagy-SIRT1 axis by Yang, Seungyeon, Moon, Subin, Hur, Soojung Claire, Jeong, Seung Min

“…Senescence, a cellular process through which damaged or dysfunctional cells suppress the cell cycle, contributes to aging or age-related functional decline…”
Get full text

Suppression of fatty acid oxidation supports pancreatic cancer growth and survival under hypoxic conditions through autophagy induction by Kim, Byungjoo, Gwak, Jihye, Kim, Minjoong, Yang, Seungyeon, Hwang, Sunsook, Shin, Seungmin, Kim, Ji Hye, Son, Jaekyoung, Jeong, Seung Min

“…Hypoxia, one of the key features of solid tumors, induces autophagy, which acts as an important adaptive mechanism for tumor progression under hypoxic…”
Get full text

Mitochondrial glutamine metabolism via GOT2 supports pancreatic cancer growth through senescence inhibition by Yang, Seungyeon, Hwang, Sunsook, Kim, Minjoong, Seo, Sung Bin, Lee, Jeong-Hwa, Jeong, Seung Min

“…Cellular senescence, which leads to a cell cycle arrest of damaged or dysfunctional cells, is an important mechanism to restrain the malignant progression of…”
Get full text

SF3B4 Regulates Cellular Senescence and Suppresses Therapy-induced Senescence of Cancer Cells by Yang, Seungyeon, Ko, Minbeom, Hur, Soojung Claire, Lee, Eun Kyung, Jeong, Seung Min

“…Cellular senescence is a state in which cells permanently exit the cell cycle, preventing tumor growth, but it can also contribute to aging and chronic…”
Get full text

Enhanced mitochondrial glutamine anaplerosis suppresses pancreatic cancer growth through autophagy inhibition by Jeong, Seung Min, Hwang, Sunsook, Park, Kyungsoo, Yang, Seungyeon, Seong, Rho Hyun

“…Cancer cells use precursors derived from tricarboxylic acid (TCA) cycle to support their unlimited growth. However, continuous export of TCA cycle…”
Get full text

PGC1α is required for the induction of contact inhibition by suppressing ROS by Yang, Seungyeon, Hwang, Sunsook, Jang, Jiho, Kim, Minjoong, Gwak, Jihye, Jeong, Seung Min

“…Contact inhibition (CI) is an important tumor-suppressive mechanism that arrests cell cycle when cells reach high density. Indeed, CI is aberrantly absent in…”
Get full text