Search Results - "Setzer, R.Woodrow"

Biological modeling of 5-fluorouracil developmental toxicity by Shuey, Dana L., Setzer, R.Woodrow, Lau, Christopher, Zucker, Robert M., Elstein, Kenneth H., Narotsky, Michael G., Kavlock, Robert J., Rogers, John M.

“…A biologically-based dose-response (BBDR) model is a mathematical description of the biological events leading to expression of a toxic response. As an…”
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Nucleoside-Mediated Mitigation of 5-Fluorouracil-Induced Toxicity in Synchronized Murine Erythroleukemic Cells by Elstein, Kenneth H., Mole, M.Leonard, Setzer, R.Woodrow, Zucker, Robert M., Kavlock, Robert J., Rogers, John M., Lau, Christopher

“…5-Fluorouracil (5-FU) is a chemotherapeutic agent known to retard embryonic growth and induce cleft palate and limb deformities. The predominant mechanism…”
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The antimutagenic effect of vanillin and cinnamaldehyde on spontaneous mutation in Salmonella TA104 is due to a reduction in mutations at GC but not AT sites by Shaughnessy, D T, Setzer, R W, DeMarini, D M

“…Vanillin (VAN) and cinnamaldehyde (CIN) are dietary antimutagens that, when added to assay plates, reduced the spontaneous mutant frequency in Salmonella…”
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Biological mechanisms and quantitative risk assessment Proceedings of a symposium sponsored by the Health Effects Research Laboratory of the U.S. Environmental Protection Agency by Setzer, R.Woodrow, Gray, L.Earl

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Quantification of t(14;18) in the lymphocytes of healthy adult humans as a possible biomarker for environmental exposures to carcinogens by Fuscoe, James C., Setzer, R.Woodrow, Collard, Deborah D., Moore, Martha M.

“…A t(14; 18) chromosomal translocation is found in ∼85% of follicular lymphomas by both cytogenetic and molecular analyses. This rearrangement deregulates…”
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Human sperm morphometry and smoking, caffeine, and alcohol consumption by Vine, Marilyn F., Setzer, R.Woodrow, Everson, Richard B., Wyrobek, Andrew J.

“…The purpose of this study is to determine whether sperm nuclear size, shape, and chromatin texture parameters are associated with lifestyle exposures including…”
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Evaluation of Biologically Based Dose–Response Modeling for Developmental Toxicity: A Workshop Report by Lau, Christopher, Andersen, Melvin E., Crawford-Brown, Douglas J., Kavlock, Robert J., Kimmel, Carole A., Knudsen, Thomas B., Muneoka, Ken, Rogers, John M., Setzer, R.Woodrow, Smith, Gary, Tyl, Rochelle

“…Biologically based dose–response (BBDR) modeling represents a novel approach for quantitative assessment of health risk by incorporating pharmacokinetic and…”
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The frequency of illegitimate V(D)J recombinase-mediated mutations in children treated with etoposide-containing antileukemic therapy by Fuscoe, James C, Knapp, Geremy W, Hanley, Nancy M, Setzer, R.Woodrow, Sandlund, John T, Pui, Ching-Hon, Relling, Mary V

“…Etoposide is among the most widely used anti-cancer drugs. Its use, however, has been associated with increased risk of secondary acute myeloid leukemia (AML)…”
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Quantification of illegitimate V(D)J recombinase-mediated mutations in lymphocytes of newborns and adults by Scheerer, J B, Xi, L, Knapp, G W, Setzer, R W, Bigbee, W L, Fuscoe, J C

“…We used a direct polymerase chain reaction (PCR) method for quantification of HPRT exons 2 + 3 deletions and t(14;18) translocations as a measure of…”
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Analysis of X-ray-induced HPRT mutations in CHO cells: insertion and deletions by Fuscoe, J C, Zimmerman, L J, Fekete, A, Setzer, R W, Rossiter, B J

“…Molecular alterations were examined in the hypoxanthine guanine phosphoribosyltransferase (hprt) gene of 41 independent X-ray-induced thioguanine-resistant…”
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