Search Results - "Setsuro Komiya"
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Neurons derived from transplanted neural stem cells restore disrupted neuronal circuitry in a mouse model of spinal cord injury
Published in The Journal of clinical investigation (01-09-2010)“…The body's capacity to restore damaged neural networks in the injured CNS is severely limited. Although various treatment regimens can partially alleviate…”
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Treatment of a Mouse Model of Spinal Cord Injury by Transplantation of Human Induced Pluripotent Stem Cell-Derived Long-Term Self-Renewing Neuroepithelial-Like Stem Cells
Published in Stem cells (Dayton, Ohio) (01-06-2012)“…Because of their ability to self‐renew, to differentiate into multiple lineages, and to migrate toward a damaged site, neural stem cells (NSCs), which can be…”
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Risk factors for surgical site infection and urinary tract infection after spine surgery
Published in European spine journal (01-12-2016)“…Purpose This study aimed to identify and compare risk factors for surgical site infection (SSI) and non-surgical site infections (non-SSIs), particularly…”
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Therapeutic time window of anti-high mobility group box-1 antibody administration in mouse model of spinal cord injury
Published in Neuroscience research (01-04-2019)“…•Administration of anti-HMGB1 mAb within 6 h after SCI improves functional recovery.•Anti-HMGB1 mAb protects the BSCB.•Anti-HMGB1 mAb suppresses inflammation…”
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BMP-induced Atoh8 attenuates osteoclastogenesis by suppressing Runx2 transcriptional activity and reducing the Rankl/Opg expression ratio in osteoblasts
Published in Bone research (02-09-2020)“…Adult bone structural integrity is maintained by remodeling via the coupling of osteoclastic bone resorption and osteoblastic bone formation. Osteocytes or…”
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Synergistic effect of arsenic trioxide, vismodegib and temozolomide on glioblastoma
Published in Oncology reports (01-06-2019)“…The treatment of glioblastoma is a critical health issue, owing to its resistance to chemotherapy. The current standard of treatment is surgical resection,…”
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Validation of Different Nutritional Assessment Tools in Predicting Prognosis of Patients with Soft Tissue Spindle-Cell Sarcomas
Published in Nutrients (13-06-2018)“…Predicting outcomes in patients with soft tissue sarcoma (STS) is challenging. To improve these predictions, we retrospectively analyzed common nutritional…”
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Differentiation of lipoma and atypical lipomatous tumor by a scoring system: implication of increased vascularity on pathogenesis of liposarcoma
Published in BMC musculoskeletal disorders (22-02-2015)“…Well-differentiated liposarcoma (WDL)/atypical lipomatous tumor (ALT) is considered a low-grade malignancy that rarely metastasizes but should be carefully…”
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Smoothened as a new therapeutic target for human osteosarcoma
Published in Molecular cancer (12-01-2010)“…The Hedgehog signaling pathway functions as an organizer in embryonic development. Recent studies have demonstrated constitutive activation of Hedgehog pathway…”
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Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis
Published in Proceedings of the National Academy of Sciences - PNAS (27-01-2009)“…Osteoarthritis (OA) is the most common joint disease and typically begins with an aging-related disruption of the articular cartilage surface. Mechanisms…”
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Clinical outcomes of arthroscopic rotator cuff repair: a retrospective comparison of double-layer, double-row and suture bridge methods
Published in BMC musculoskeletal disorders (11-09-2018)“…The suture-bridge (SB) method has recently become the mainstream means of repairing full-thickness rotator cuff tears. However, in some patients the deep and…”
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The diagnostic value of single-photon emission computed tomography/computed tomography for severe sacroiliac joint dysfunction
Published in European spine journal (01-04-2015)“…Purpose We aimed to evaluate the value of single-photon emission computed tomography (SPECT)/computed tomography (CT) for the diagnosis of sacroiliac joint…”
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Tranilast enhances the effect of anticancer agents in osteosarcoma
Published in Oncology reports (01-07-2019)“…Tranilast [N‑(3',4'‑dimethoxycinnamoyl)‑anthranilic acid], initially developed as an antiallergic drug, also exhibits a growth inhibitory effect on various…”
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Clinical course of the bony lesion of single-system single-site Langerhans cell histiocytosis – Is appropriate follow-up sufficient treatment?
Published in Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association (01-01-2018)“…Langerhans cell histiocytosis (LCH) is categorized into three types, which include single-system single-site (SS-s), single-system multiple-site (SS-m) and…”
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The effect of ultraviolet photofunctionalization of titanium instrumentation in lumbar fusion: a non-randomized controlled trial
Published in BMC musculoskeletal disorders (18-06-2019)“…Titanium instrumentations are widely used in orthopedics; the metal bonds with bone in a process called osseointegration. Over time, hydrocarbons adhere to the…”
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Ribosomal protein S3 regulates GLI2-mediated osteosarcoma invasion
Published in Cancer letters (28-01-2015)“…Highlights • RPS3 was identified as a novel downstream gene of GLI2. • Knockdown of GLI2 decreased RPS3 expression in osteosarcoma cells. • RPS3 knockdown…”
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Accumulation of p62 in degenerated spinal cord under chronic mechanical compression: Functional analysis of p62 and autophagy in hypoxic neuronal cells
Published in Autophagy (01-12-2011)“…Intracellular accumulation of altered proteins, including p62 and ubiquitinated proteins, is the basis of most neurodegenerative disorders. The relationship…”
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Association between bone mineral density, muscle volume, walking ability, and geriatric nutritional risk index in hemodialysis patients
Published in Asia Pacific Journal of Clinical Nutrition (01-09-2018)“…Background and Objectives: Hemodialysis patients are at risk for bone loss and sarcopenia, characterized by reduced muscle mass and limited mobility/function…”
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Predictive factors of mortality and deterioration in performance of activities of daily living after hip fracture surgery in Kagoshima, Japan
Published in Geriatrics & gerontology international (01-03-2017)“…Aim Given that different hospitals achieve different outcomes, optimal evaluation of treatment outcomes in the local community requires evaluation of many…”
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