Search Results - "Setou, Mitsutoshi"

Dynamic Remodeling of Membrane Composition Drives Cell Cycle through Primary Cilia Excision by Phua, Siew Cheng, Chiba, Shuhei, Suzuki, Masako, Su, Emily, Roberson, Elle C., Pusapati, Ganesh V., Setou, Mitsutoshi, Rohatgi, Rajat, Reiter, Jeremy F., Ikegami, Koji, Inoue, Takanari

“…The life cycle of a primary cilium begins in quiescence and ends prior to mitosis. In quiescent cells, the primary cilium insulates itself from contiguous…”
Get full text

A pair of primers facing at the double-strand break site enables to detect NHEJ-mediated indel mutations at a 1-bp resolution by Ijaz, Faryal, Nakazato, Ryota, Setou, Mitsutoshi, Ikegami, Koji

“…The introduction of small insertion/deletion (indel) mutations in the coding region of genes by the site-specific nucleases such as Cas9 allows researchers to…”
Get full text

Method for Simultaneous Imaging of Endogenous Low Molecular Weight Metabolites in Mouse Brain Using TiO2 Nanoparticles in Nanoparticle-Assisted Laser Desorption/Ionization-Imaging Mass Spectrometry by Shrivas, Kamlesh, Hayasaka, Takahiro, Sugiura, Yuki, Setou, Mitsutoshi

“…We report the detection of a group of endogenous low molecular weight metabolites (LMWM) in mouse brain (80–500 Da) using TiO2 nanoparticles (NPs) in…”
Get full text

STING, a cytosolic DNA sensor, plays a critical role in atherogenesis: a link between innate immunity and chronic inflammation caused by lifestyle-related diseases by Pham, Phuong Tran, Fukuda, Daiju, Nishimoto, Sachiko, Kim-Kaneyama, Joo-Ri, Lei, Xiao-Feng, Takahashi, Yutaka, Sato, Tomohito, Tanaka, Kimie, Suto, Kumiko, Kawabata, Yutaka, Yamaguchi, Koji, Yagi, Shusuke, Kusunose, Kenya, Yamada, Hirotsugu, Soeki, Takeshi, Wakatsuki, Tetsuzo, Shimada, Kenji, Kanematsu, Yasuhisa, Takagi, Yasushi, Shimabukuro, Michio, Setou, Mitsutoshi, Barber, Glen N, Sata, Masataka

“…Abstract Aims Lifestyle-related diseases promote atherosclerosis, a chronic inflammatory disease; however, the molecular mechanism remains largely unknown…”
Get full text

Brain distribution of geissoschizine methyl ether in rats using mass spectrometry imaging analysis by Matsumoto, Takashi, Ikarashi, Yasushi, Takiyama, Mikina, Watanabe, Junko, Setou, Mitsutoshi

“…Geissoschizine methyl ether (GM) is one of the main active ingredients responsible for ameliorating the behavioral and psychological symptoms of dementia…”
Get full text

SCRAPPER Selectively Contributes to Spontaneous Release and Presynaptic Long-Term Potentiation in the Anterior Cingulate Cortex by Koga, Kohei, Yao, Ikuko, Setou, Mitsutoshi, Zhuo, Min

“…SCRAPPER is an E3 ubiquitin ligase expressed in presynaptic terminals, neural cell body, and dendrites of the hippocampus and cortex, which is coded by the…”
Get full text

Pharmacokinetic study of Ninjin'yoeito: Absorption and brain distribution of Ninjin'yoeito ingredients in mice by Matsumoto, Takashi, Takiyama, Mikina, Sakamoto, Takumi, Kaifuchi, Noriko, Watanabe, Junko, Takahashi, Yutaka, Setou, Mitsutoshi

“…Ninjin'yoeito (NYT), a Japanese traditional Kampo medicine, has been reported to exert various clinical benefits such as relief from fatigue, malaise,…”
Get full text

Imaging Mass Spectrometry for Visualization of Drug and Endogenous Metabolite Distribution: Toward In Situ Pharmacometabolomes by Sugiura, Yuki, Setou, Mitsutoshi

“…It is important to determine how a candidate drug is distributed and metabolized within the body in early phase of drug discovery. Recently, matrix-assisted…”
Get full text

Hypertrophy of the ligamentum flavum in lumbar spinal canal stenosis is associated with abnormal accumulation of specific lipids by Yamada, Tomohiro, Horikawa, Makoto, Sato, Tomohito, Kahyo, Tomoaki, Takanashi, Yusuke, Ushirozako, Hiroki, Kurosu, Kenta, Al Mamun, Md, Mihara, Yuki, Oe, Shin, Arima, Hideyuki, Banno, Tomohiro, Yosida, Go, Hasegawa, Tomohiko, Yamato, Yu, Matsuyama, Yukihiro, Setou, Mitsutoshi

“…Ligamentum flavum hypertrophy (HLF) is the most important component of lumbar spinal canal stenosis (LSCS). Analysis of hypertrophied ligamentum flavum (HLF)…”
Get full text

MALDI-based imaging mass spectrometry revealed abnormal distribution of phospholipids in colon cancer liver metastasis by Shimma, Shuichi, Sugiura, Yuki, Hayasaka, Takahiro, Hoshikawa, Yutaka, Noda, Tetsuo, Setou, Mitsutoshi

“…We present the results of matrix-assisted laser desorption/ionization (MALDI) imaging and direct molecular identification using tandem mass spectrometry…”
Get full text

Region-specific effects of Scrapper on the abundance of glutamate and gamma-aminobutyric acid in the mouse brain by Eto, Fumihiro, Sato, Shumpei, Setou, Mitsutoshi, Yao, Ikuko

“…The brain consists of various areas with anatomical features. Neurons communicate with one another via excitatory or inhibitory synaptic transmission. Altered…”
Get full text

Induction of Endothelial Nitric Oxide Synthase, SIRT1, and Catalase by Statins Inhibits Endothelial Senescence Through the Akt Pathway by Ota, Hidetaka, Eto, Masato, Kano, Mitsunobu R, Kahyo, Tomoaki, Setou, Mitsutoshi, Ogawa, Sumito, Iijima, Katsuya, Akishita, Masahiro, Ouchi, Yasuyoshi

“…OBJECTIVE—Statins (3-hydroxy-3-methylglutaryl–coenzyme A reductase inhibitors) have pleiotropic vascular protective effects besides cholesterol lowering…”
Get full text

Overexpression of Lysophosphatidylcholine Acyltransferase 1 and Concomitant Lipid Alterations in Gastric Cancer by Uehara, Takashi, Kikuchi, Hirotoshi, Miyazaki, Shinichiro, Iino, Ichirota, Setoguchi, Tomohiko, Hiramatsu, Yoshihiro, Ohta, Manabu, Kamiya, Kinji, Morita, Yoshifumi, Tanaka, Hiroki, Baba, Satoshi, Hayasaka, Takahiro, Setou, Mitsutoshi, Konno, Hiroyuki

“…Background The involvement of lipids in carcinogenic and developmental processes has been reported in some malignancies, but their roles in gastric cancer…”
Get full text

Accumulated phosphatidylcholine (16:0/16:1) in human colorectal cancer; possible involvement of LPCAT4 by Kurabe, Nobuya, Hayasaka, Takahiro, Ogawa, Mikako, Masaki, Noritaka, Ide, Yoshimi, Waki, Michihiko, Nakamura, Toshio, Kurachi, Kiyotaka, Kahyo, Tomoaki, Shinmura, Kazuya, Midorikawa, Yutaka, Sugiyama, Yasuyuki, Setou, Mitsutoshi, Sugimura, Haruhiko

“…The identification of cancer biomarkers is critical for target‐linked cancer therapy. The overall level of phosphatidylcholine (PC) is elevated in colorectal…”
Get full text

MALDI imaging mass spectrometry revealed atropine distribution in the ocular tissues and its transit from anterior to posterior regions in the whole-eye of rabbit after topical administration by Mori, Naoto, Mochizuki, Takaharu, Yamazaki, Fumiyoshi, Takei, Shiro, Mano, Hidetoshi, Matsugi, Takeshi, Setou, Mitsutoshi

“…It is essential to elucidate drug distribution in the ocular tissues and drug transit in the eye for ophthalmic pharmaceutical manufacturers. Atropine is a…”
Get full text

Tubulin polyglutamylation is essential for airway ciliary function through the regulation of beating asymmetry by Ikegami, Koji, Sato, Showbu, Nakamura, Kenji, Ostrowski, Lawrence E, Setou, Mitsutoshi

“…Airway epithelial cilia protect the mammalian respiratory system from harmful inhaled materials by providing the force necessary for effective mucociliary…”
Get full text

Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut by Kunisawa, Jun, Arita, Makoto, Hayasaka, Takahiro, Harada, Takashi, Iwamoto, Ryo, Nagasawa, Risa, Shikata, Shiori, Nagatake, Takahiro, Suzuki, Hidehiko, Hashimoto, Eri, Kurashima, Yosuke, Suzuki, Yuji, Arai, Hiroyuki, Setou, Mitsutoshi, Kiyono, Hiroshi

“…ω3 polyunsaturated fatty acids (PUFAs) have anti-allergic and anti-inflammatory properties, but the immune-metabolic progression from dietary oil remains to be…”
Get full text

Visualization of the cell-selective distribution of PUFA-containing phosphatidylcholines in mouse brain by imaging mass spectrometry[S] by Sugiura, Yuki, Konishi, Yoshiyuki, Zaima, Nobuhiro, Kajihara, Shigeki, Nakanishi, Hiroki, Taguchi, Ryo, Setou, Mitsutoshi

“…Previous studies have shown that MALDI-imaging mass spectrometry (IMS) can be used to visualize the distribution of various biomolecules, especially lipids, in…”
Get full text

Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression by Morita, Yoshifumi, Sakaguchi, Takanori, Ikegami, Koji, Goto-Inoue, Naoko, Hayasaka, Takahiro, Hang, Vu Thi, Tanaka, Hiroki, Harada, Takashi, Shibasaki, Yasushi, Suzuki, Atsushi, Fukumoto, Kazuhiko, Inaba, Keisuke, Murakami, Makoto, Setou, Mitsutoshi, Konno, Hiroyuki

“…Background & Aims Several lipid synthesis pathways play important roles in the development and progression of hepatocellular carcinoma (HCC), although the…”
Get full text

Recurrent triple-negative breast cancer (TNBC) tissues contain a higher amount of phosphatidylcholine (32:1) than non-recurrent TNBC tissues by Hosokawa, Yuko, Masaki, Noritaka, Takei, Shiro, Horikawa, Makoto, Matsushita, Shoko, Sugiyama, Eiji, Ogura, Hiroyuki, Shiiya, Norihiko, Setou, Mitsutoshi

“…Triple-negative breast cancer (TNBC) is one of the breast cancer subtype that displays a high risk of early recurrence and short overall survival. Improvement…”
Get full text