Search Results - "Sethi, Gautam"

Bioactive natural products in cancer prevention and therapy: Progress and promise by Bishayee, Anupam, PhD, Sethi, Gautam, PhD

“…Abstract Natural products represent a rich source for the discovery and development of cancer preventive and anticancer drugs. Nearly, 80% of all drugs…”
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The multifaceted role of reactive oxygen species in tumorigenesis by Kirtonia, Anuradha, Sethi, Gautam, Garg, Manoj

“…Redox homeostasis is an essential requirement of the biological systems for performing various normal cellular functions including cellular growth,…”
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Association of the Epithelial-Mesenchymal Transition (EMT) with Cisplatin Resistance by Ashrafizadeh, Milad, Zarrabi, Ali, Hushmandi, Kiavash, Kalantari, Mahshad, Mohammadinejad, Reza, Javaheri, Tahereh, Sethi, Gautam

“…Therapy resistance is a characteristic of cancer cells that significantly reduces the effectiveness of drugs. Despite the popularity of cisplatin (CP) as a…”
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Targeting autophagy using natural compounds for cancer prevention and therapy by Deng, Shuo, Shanmugam, Muthu K., Kumar, Alan Prem, Yap, Celestial T., Sethi, Gautam, Bishayee, Anupam

“…Autophagy, also known as macroautophagy, is a tightly regulated process involved in the stress responses, such as starvation. It is a vacuolar, lysosomal…”
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Targeting activator protein 1 signaling pathway by bioactive natural agents: Possible therapeutic strategy for cancer prevention and intervention by Tewari, Devesh, Nabavi, Seyed Fazel, Nabavi, Seyed Mohammad, Sureda, Antoni, Farooqi, Ammad Ahmad, Atanasov, Atanas G., Vacca, Rosa Anna, Sethi, Gautam, Bishayee, Anupam

“…[Display omitted] •Activator protein 1 (AP-1) has a key role in several cellular processes.•Targeting AP-1 signaling pathways is therapeutic for cancer and…”
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A comprehensive review of genetic alterations and molecular targeted therapies for the implementation of personalized medicine in acute myeloid leukemia by Kirtonia, Anuradha, Pandya, Gouri, Sethi, Gautam, Pandey, Amit Kumar, Das, Bhudev C, Garg, Manoj

“…Acute myeloid leukemia (AML) is an extremely heterogeneous disease defined by the clonal growth of myeloblasts/promyelocytes not only in the bone marrow but…”
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Repurposing of drugs: An attractive pharmacological strategy for cancer therapeutics by Kirtonia, Anuradha, Gala, Kavita, Fernandes, Stina George, Pandya, Gouri, Pandey, Amit Kumar, Sethi, Gautam, Khattar, Ekta, Garg, Manoj

“…Human malignancies are one of the major health-related issues though out the world and anticipated to rise in the future. The development of novel drugs/agents…”
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The Role of Resveratrol in Cancer Therapy by Ko, Jeong-Hyeon, Sethi, Gautam, Um, Jae-Young, Shanmugam, Muthu K, Arfuso, Frank, Kumar, Alan Prem, Bishayee, Anupam, Ahn, Kwang Seok

“…Natural product compounds have recently attracted significant attention from the scientific community for their potent effects against inflammation-driven…”
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Antioxidant response elements: Discovery, classes, regulation and potential applications by Raghunath, Azhwar, Sundarraj, Kiruthika, Nagarajan, Raju, Arfuso, Frank, Bian, Jinsong, Kumar, Alan P., Sethi, Gautam, Perumal, Ekambaram

“…Exposure to antioxidants and xenobiotics triggers the expression of a myriad of genes encoding antioxidant proteins, detoxifying enzymes, and xenobiotic…”
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Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer by Kannaiyan, Radhamani, Shanmugam, Muthu K, Sethi, Gautam

“…Abstract Identification of active constituents and their molecular targets from traditional medicine is an enormous opportunity for modern pharmacology…”
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Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication by Loh, Chin-Yap, Arya, Aditya, Naema, Ahmed Fadhil, Wong, Won Fen, Sethi, Gautam, Looi, Chung Yeng

“…Signal Transducer and Activator of Transcription (STAT) pathway is connected upstream with Janus kinases (JAK) family protein and capable of integrating inputs…”
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Regulation of Nuclear Factor-KappaB (NF-κB) signaling pathway by non-coding RNAs in cancer: Inhibiting or promoting carcinogenesis? by Mirzaei, Sepideh, Zarrabi, Ali, Hashemi, Farid, Zabolian, Amirhossein, Saleki, Hossein, Ranjbar, Adnan, Seyed Saleh, Seyed Hesam, Bagherian, Morteza, Sharifzadeh, Seyed omid, Hushmandi, Kiavash, Liskova, Alena, Kubatka, Peter, Makvandi, Pooyan, Tergaonkar, Vinay, Kumar, Alan Prem, Ashrafizadeh, Milad, Sethi, Gautam

“…The nuclear factor-kappaB (NF-κB) signaling pathway is considered as a potential therapeutic target in cancer therapy. It has been well established that…”
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Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements by Aggarwal, Vaishali, Tuli, Hardeep Singh, Varol, Ayşegül, Thakral, Falak, Yerer, Mukerrem Betul, Sak, Katrin, Varol, Mehmet, Jain, Aklank, Khan, Md Asaduzzaman, Sethi, Gautam

“…Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous ROS production in normal cells is controlled by the appropriate…”
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Wnt signaling mediates TLR pathway and promote unrestrained adipogenesis and metaflammation: Therapeutic targets for obesity and type 2 diabetes by Aamir, Khurram, Khan, Hidayat Ullah, Sethi, Gautam, Hossain, Mohammed Akhter, Arya, Aditya

“…[Display omitted] Diabesity is the combination of type 2 diabetes and obesity characterized by chronic low-grade inflammation. The Wnt signaling act as an…”
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Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects by Abadi, Asal Jalal, Mirzaei, Sepideh, Mahabady, Mahmood Khaksary, Hashemi, Farid, Zabolian, Amirhossein, Hashemi, Fardin, Raee, Pourya, Aghamiri, Shahin, Ashrafizadeh, Milad, Aref, Amir Reza, Hamblin, Michael R., Hushmandi, Kiavash, Zarrabi, Ali, Sethi, Gautam

“…Curcumin is a phytochemical isolated from Curcuma longa with potent tumor‐suppressor activity, which has shown significant efficacy in pre‐clinical and…”
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TNF: a master switch for inflammation to cancer by Sethi, Gautam, Sung, Bokyung, Aggarwal, Bharat B

“…Chronic inflammation has long been associated with the development of cancer, ever since Rudolf Virchow's first observation that leukocytes were present in…”
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A bioinformatics analysis, pre-clinical and clinical conception of autophagy in pancreatic cancer: Complexity and simplicity in crosstalk by Ashrafizadeh, Milad, Zhang, Wei, Zou, Rongjun, Sethi, Gautam, Klionsky, Daniel J., Zhang, Xianbin

“…Pancreatic cancer (PC) is a serious gastrointestinal tract disease for which the 5-year survival rate is less than 10%, even in developed countries such as the…”
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Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review by Moballegh Nasery, Mahshid, Abadi, Banafshe, Poormoghadam, Delaram, Zarrabi, Ali, Keyhanvar, Peyman, Khanbabaei, Hashem, Ashrafizadeh, Milad, Mohammadinejad, Reza, Tavakol, Shima, Sethi, Gautam

“…Todays, nano-pharmaceutics is emerging as an important field of science to develop and improve efficacy of different drugs. Although nutraceuticals are…”
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Dual role of autophagy in hallmarks of cancer by Singh, Shikha Satendra, Vats, Somya, Chia, Amelia Yi-Qian, Tan, Tuan Zea, Deng, Shuo, Ong, Mei Shan, Arfuso, Frank, Yap, Celestial T., Goh, Boon Cher, Sethi, Gautam, Huang, Ruby Yun-Ju, Shen, Han Ming, Manjithaya, Ravi, Kumar, Alan Prem

“…Evolutionarily conserved across eukaryotic cells, macroautophagy (herein autophagy) is an intracellular catabolic degradative process targeting damaged and…”
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Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel by Lee, Jong Hyun, Kim, Chulwon, Sethi, Gautam, Ahn, Kwang Seok

“…Persistent phosphorylation of signal transducers and activators of transcription 3 (STAT3) is frequently observed in tumor cells. We found that brassinin (BSN)…”
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