Search Results - "Seth Love"

Cognitive impact of COVID-19: looking beyond the short term by Miners, Scott, Kehoe, Patrick G, Love, Seth

“…COVID-19 is primarily a respiratory disease but up to two thirds of hospitalised patients show evidence of central nervous system (CNS) damage, predominantly…”
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The concept of sporadic cerebral small vessel disease: A road map on key definitions and current concepts by Charidimou, Andreas, Pantoni, Leonardo, Love, Seth

“…Sporadic cerebral small vessel disease is considered to be among the most common known neuropathological processes and has an important role in stroke,…”
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A critical review of the epidemiological evidence of effects of air pollution on dementia, cognitive function and cognitive decline in adult population by Delgado-Saborit, Juana Maria, Guercio, Valentina, Gowers, Alison M., Shaddick, Gavin, Fox, Nick C., Love, Seth

“…Dementia is arguably the most pressing public health challenge of our age. Since dementia does not have a cure, identifying risk factors that can be controlled…”
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Pathophysiology of Hypoperfusion of the Precuneus in Early Alzheimer's Disease by Miners, J. Scott, Palmer, Jennifer C., Love, Seth

“…The earliest decline in cerebral perfusion in Alzheimer's disease (AD) is in the medial parietal cortex (precuneus). We have analyzed precuneus in post‐mortem…”
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Inflammatory components in human Alzheimer's disease and after active amyloid-β42 immunization by ZOTOVA, Elina, BHARAMBE, Viraj, CHEAVEAU, Matthew, MORGAN, William, HOLMES, Clive, HARRIS, Scott, NEAL, James W, LOVE, Seth, NICOLL, James A. R, BOCHE, Delphine

“…Inflammatory processes are important in the pathogenesis of Alzheimer's disease and in response to amyloid-β immunotherapy. We investigated the expression of…”
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Fatty Acid Composition of Frontal, Temporal and Parietal Neocortex in the Normal Human Brain and in Alzheimer’s Disease by Fraser, Thomas, Tayler, Hannah, Love, Seth

“…Dietary ω3-polyunsaturated fatty acids are thought to influence the risk of Alzheimer’s disease (AD), and supplemental docosahexaenoic acid (DHA; 22:6n-3) has…”
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Oxidative Stress in Brain Ischemia by Love, Seth

“…Brain ischemia initiates a complex cascade of metabolic events, several of which involve the generation of nitrogen and oxygen free radicals. These free…”
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Convection-Enhanced Drug Delivery to the Brain: Therapeutic Potential and Neuropathological Considerations by Barua, Neil U., Gill, Steven S., Love, Seth

“…Convection‐enhanced delivery (CED) describes a direct method of drug delivery to the brain through intraparenchymal microcatheters. By establishing a pressure…”
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DNA methylation signatures of Alzheimer’s disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types by Shireby, Gemma, Dempster, Emma L., Policicchio, Stefania, Smith, Rebecca G., Pishva, Ehsan, Chioza, Barry, Davies, Jonathan P., Burrage, Joe, Lunnon, Katie, Seiler Vellame, Dorothea, Love, Seth, Thomas, Alan, Brookes, Keeley, Morgan, Kevin, Francis, Paul, Hannon, Eilis, Mill, Jonathan

“…Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by the progressive accumulation of amyloid-beta and neurofibrillary tangles of…”
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Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial by Holmes, Clive, Prof, Boche, Delphine, PhD, Wilkinson, David, FRCPsych, Yadegarfar, Ghasem, PhD, Hopkins, Vivienne, RMN, Bayer, Anthony, MRCP, Jones, Roy W, Prof, Bullock, Roger, MRCPsych, Love, Seth, Prof, Neal, James W, FRCPath, Zotova, Elina, BSc, Nicoll, James AR, Prof

“…Summary Background Immunisation of patients with Alzheimer's disease with full-length amyloid-β peptide (Aβ42 ) can clear amyloid plaques from the brain. Our…”
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Pericyte Contractile Responses to Endothelin-1 and Aβ Peptides: Assessment by Electrical Impedance Assay by Hibbs, Elliott, Love, Seth, Miners, J. Scott

“…Pericytes are vascular mural cells that contract and relax in response to vasoactive stimuli to regulate neurovascular coupling and cerebral blood flow…”
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APOE ε4, Alzheimer's disease neuropathology and sleep disturbance, in individuals with and without dementia by Blackman, Jonathan, Love, Seth, Sinclair, Lindsey, Cain, Richard, Coulthard, Elizabeth

“…Apolipoprotein E epsilon 4 (APOE-ε4) carrier status is an established risk factor for Alzheimer's disease (AD) dementia. It has also been linked with sleep…”
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White Matter Hypoperfusion and Damage in Dementia: Post-Mortem Assessment by Love, Seth, Miners, J Scott

“…Neuroimaging has revealed a range of white matter abnormalities that are common in dementia, some that predict cognitive decline. The abnormalities may result…”
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Endothelin receptor antagonists: Potential in Alzheimer's disease by Palmer, Jennifer, Love, Seth

“…Alzheimer's disease (AD) is believed to be initiated by the accumulation of neurotoxic forms of Aβ peptide within the brain. AD patients show reduction of…”
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Assessing White Matter Ischemic Damage in Dementia Patients by Measurement of Myelin Proteins by Barker, Rachel, Wellington, Dannielle, Esiri, Margaret M, Love, Seth

“…White matter ischemia is difficult to quantify histologically. Myelin-associated glycoprotein (MAG) is highly susceptible to ischemia, being expressed only…”
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Do synaptic changes occur before old age in people at high genetic risk of Alzheimer's disease? by Sinclair, Lindsey, Dr, Love, Seth, Prof

“…Abstract Background Possession of an ɛ4 allele of the APOE gene is the main known genetic risk factor for late-onset Alzheimer's disease. Neuropathological…”
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Pathophysiology of white matter perfusion in Alzheimer’s disease and vascular dementia by Barker, Rachel, Ashby, Emma L., Wellington, Dannielle, Barrow, Vivienne M., Palmer, Jennifer C., Kehoe, Patrick G., Esiri, Margaret M., Love, Seth

“…The pathophysiology of white matter hypoperfusion is poorly understood. Barker et al. quantify ante-mortem hypoperfusion by measuring myelin proteins…”
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Epigenome-wide association study of human frontal cortex identifies differential methylation in Lewy body pathology by Pihlstrøm, Lasse, Shireby, Gemma, Geut, Hanneke, Henriksen, Sandra Pilar, Rozemuller, Annemieke J. M., Tunold, Jon-Anders, Hannon, Eilis, Francis, Paul, Thomas, Alan J., Love, Seth, Mill, Jonathan, van de Berg, Wilma D. J., Toft, Mathias

“…Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) are closely related progressive disorders with no available disease-modifying therapy,…”
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ENDOTHELIN-1-MEDIATED CONTRACTION OF HUMAN BRAIN PERICYTES IS DYSREGULATED IN THE PRESENCE OF Aβ1-40 by Hibbs, Elliott, Love, Seth, Miners, Scott

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Does aquatic invasive species removal benefit native fish? The response of gizzard shad (Dorosoma cepedianum) to commercial harvest of bighead carp (Hypophthalmichthys nobilis) and silver carp (H. molitrix) by Love, Seth A., Lederman, Nathan J., Anderson, Rebekah L., DeBoer, Jason A., Casper, Andrew F.

“…Bighead carp ( Hypophthalmichthys nobilis ) and silver carp ( H. molitrix ), collectively known as Asian carp, are planktivorous fishes that have invaded…”
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