Search Results - "Seth Ament"

The brain's dark transcriptome: Sequencing RNA in distal compartments of neurons and glia by Ament, Seth A., Poulopoulos, Alexandros

“…Transcriptomic approaches are powerful strategies to map the molecular diversity of cells in the brain. Single-cell genomic atlases have now been compiled for…”
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Biological insights from multi-omic analysis of 31 genomic risk loci for adult hearing difficulty by Kalra, Gurmannat, Milon, Beatrice, Casella, Alex M, Herb, Brian R, Humphries, Elizabeth, Song, Yang, Rose, Kevin P, Hertzano, Ronna, Ament, Seth A

“…Age-related hearing impairment (ARHI), one of the most common medical conditions, is strongly heritable, yet its genetic causes remain largely unknown. We…”
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Single-cell epigenomics reveals mechanisms of human cortical development by Ziffra, Ryan S., Kim, Chang N., Ross, Jayden M., Wilfert, Amy, Turner, Tychele N., Haeussler, Maximilian, Casella, Alex M., Przytycki, Pawel F., Keough, Kathleen C., Shin, David, Bogdanoff, Derek, Kreimer, Anat, Pollard, Katherine S., Ament, Seth A., Eichler, Evan E., Ahituv, Nadav, Nowakowski, Tomasz J.

“…During mammalian development, differences in chromatin state coincide with cellular differentiation and reflect changes in the gene regulatory landscape 1 . In…”
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Identifying enhancer properties associated with genetic risk for complex traits using regulome-wide association studies by Casella, Alex M, Colantuoni, Carlo, Ament, Seth A

“…Genetic risk for complex traits is strongly enriched in non-coding genomic regions involved in gene regulation, especially enhancers. However, we lack adequate…”
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Genome wide association joint analysis reveals 99 risk loci for pain susceptibility and pleiotropic relationships with psychiatric, metabolic, and immunological traits by Mocci, Evelina, Ward, Kathryn, Perry, James A, Starkweather, Angela, Stone, Laura S, Schabrun, Siobhan M, Renn, Cynthia, Dorsey, Susan G, Ament, Seth A

“…Chronic pain is at epidemic proportions in the United States, represents a significant burden on our public health system, and is coincident with a growing…”
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gEAR: Gene Expression Analysis Resource portal for community-driven, multi-omic data exploration by Orvis, Joshua, Gottfried, Brian, Kancherla, Jayaram, Adkins, Ricky S., Song, Yang, Dror, Amiel A., Olley, Dustin, Rose, Kevin, Chrysostomou, Elena, Kelly, Michael C., Milon, Beatrice, Matern, Maggie S., Azaiez, Hela, Herb, Brian, Colantuoni, Carlo, Carter, Robert L., Ament, Seth A., Kelley, Matthew W., White, Owen, Bravo, Hector Corrada, Mahurkar, Anup, Hertzano, Ronna

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Insulin signaling is involved in the regulation of worker division of labor in honey bee colonies by Ament, Seth A, Corona, Miguel, Pollock, Henry S, Robinson, Gene E

“…It has been proposed that one route of behavioral evolution involves novel regulation of conserved genes. Age-related division of labor in honey bee colonies,…”
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Reproductive tract extracellular vesicles are sufficient to transmit intergenerational stress and program neurodevelopment by Chan, Jennifer C., Morgan, Christopher P., Adrian Leu, N., Shetty, Amol, Cisse, Yasmine M., Nugent, Bridget M., Morrison, Kathleen E., Jašarević, Eldin, Huang, Weiliang, Kanyuch, Nickole, Rodgers, Ali B., Bhanu, Natarajan V., Berger, Dara S., Garcia, Benjamin A., Ament, Seth, Kane, Maureen, Neill Epperson, C., Bale, Tracy L.

“…Extracellular vesicles (EVs) are a unique mode of intercellular communication capable of incredible specificity in transmitting signals involved in cellular…”
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A single-cell genomic atlas for maturation of the human cerebellum during early childhood by Ament, Seth A, Cortes-Gutierrez, Marcia, Herb, Brian R, Mocci, Evelina, Colantuoni, Carlo, McCarthy, Margaret M

“…Inflammation early in life is a clinically established risk factor for autism spectrum disorders and schizophrenia, yet the impact of inflammation on human…”
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Behavior-specific changes in transcriptional modules lead to distinct and predictable neurogenomic states by Chandrasekaran, Sriram, Ament, Seth A., Eddy, James A., Rodriguez-Zas, Sandra L., Schatz, Bruce R., Price, Nathan D., Robinson, Gene E.

“…Using brain transcriptomic profiles from 853 individual honey bees exhibiting 48 distinct behavioral phenotypes in naturalistic contexts, we report that…”
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Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal Cell Identity Due to Huntington's Disease Mutations by Malaiya, Sonia, Cortes-Gutierrez, Marcia, Herb, Brian R, Coffey, Sydney R, Legg, Samuel R W, Cantle, Jeffrey P, Colantuoni, Carlo, Carroll, Jeffrey B, Ament, Seth A

“…Huntington's disease (HD) is a dominantly inherited neurodegenerative disorder caused by a trinucleotide expansion in exon 1 of the huntingtin ( ) gene. Cell…”
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The transcription factor ultraspiracle influences honey bee social behavior and behavior-related gene expression by Ament, Seth A, Wang, Ying, Chen, Chieh-Chun, Blatti, Charles A, Hong, Feng, Liang, Zhengzheng S, Negre, Nicolas, White, Kevin P, Rodriguez-Zas, Sandra L, Mizzen, Craig A, Sinha, Saurabh, Zhong, Sheng, Robinson, Gene E

“…Behavior is among the most dynamic animal phenotypes, modulated by a variety of internal and external stimuli. Behavioral differences are associated with…”
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Predicting Heterogeneity in Patient Response to Morphine Treatment for Neonatal Opioid Withdrawal Syndrome by Smolyak, Daniel, Humphries, Elizabeth M., Parikh, Abhinav, Gopalakrishnan, Mathangi, Aycan, Fulden, Bjarnadóttir, Margrét, Ament, Seth A., El‐Metwally, Dina, Beitelshees, Amber, Agarwal, Ritu

“…Infants with neonatal opioid withdrawal syndrome commonly receive morphine treatment to manage their withdrawal signs. However, the effectiveness of this…”
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Rediscovering the value of families for psychiatric genetics research by Glahn, David C., Nimgaonkar, Vishwajit L., Raventós, Henriette, Contreras, Javier, McIntosh, Andrew M., Thomson, Pippa A., Jablensky, Assen, McCarthy, Nina S., Charlesworth, Jac C., Blackburn, Nicholas B., Peralta, Juan Manuel, Knowles, Emma E. M., Mathias, Samuel R., Ament, Seth A., McMahon, Francis J., Gur, Ruben C., Bucan, Maja, Curran, Joanne E., Almasy, Laura, Gur, Raquel E., Blangero, John

“…As it is likely that both common and rare genetic variation are important for complex disease risk, studies that examine the full range of the allelic…”
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Adaptations in Nucleus Accumbens Neuron Subtypes Mediate Negative Affective Behaviors in Fentanyl Abstinence by Fox, Megan E., Wulff, Andreas B., Franco, Daniela, Choi, Eric Y., Calarco, Cali A., Engeln, Michel, Turner, Makeda D., Chandra, Ramesh, Rhodes, Victoria M., Thompson, Scott M., Ament, Seth A., Lobo, Mary Kay

“…Opioid discontinuation generates a withdrawal syndrome marked by increased negative affect. Increased symptoms of anxiety and dysphoria during opioid…”
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Transcriptomic profiling of reward and sensory brain areas in perinatal fentanyl exposed juvenile mice by Olusakin, Jimmy, Kumar, Gautam, Basu, Mahashweta, Calarco, Cali A, Fox, Megan E, Alipio, Jason B, Haga, Catherine, Turner, Makeda D, Keller, Asaf, Ament, Seth A, Lobo, Mary Kay

“…Use of the synthetic opioid fentanyl increased ~300% in the last decade, including among women of reproductive ages. Adverse neonatal outcomes and long-term…”
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Cochlear organoids reveal transcriptional programs of postnatal hair cell differentiation from supporting cells by Kalra, Gurmannat, Lenz, Danielle, Abdul-Aziz, Dunia, Hanna, Craig, Basu, Mahashweta, Herb, Brian R., Colantuoni, Carlo, Milon, Beatrice, Saxena, Madhurima, Shetty, Amol C., Hertzano, Ronna, Shivdasani, Ramesh A., Ament, Seth A., Edge, Albert S.B.

“…We explore the changes in chromatin accessibility and transcriptional programs for cochlear hair cell differentiation from postmitotic supporting cells using…”
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Transcriptional signatures of fentanyl use in the mouse ventral tegmental area by Fox, Megan E., Montemarano, Annalisa, Ostman, Alexandria E., Basu, Mahashweta, Herb, Brian, Ament, Seth A., Fox, Logan D.

“…Synthetic opioids such as fentanyl contribute to the vast majority of opioid‐related overdose deaths, but fentanyl use remains broadly understudied. Like other…”
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Cell type-specific genes show striking and distinct patterns of spatial expression in the mouse brain by Ko, Younhee, Ament, Seth A., Eddy, James A., Caballero, Juan, Earls, John C., Hood, Leroy, Price, Nathan D.

“…To characterize gene expression patterns in the regional subdivisions of the mammalian brain, we integrated spatial gene expression patterns from the Allen…”
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Transcriptional regulatory networks underlying gene expression changes in Huntington's disease by Ament, Seth A, Pearl, Jocelynn R, Cantle, Jeffrey P, Bragg, Robert M, Skene, Peter J, Coffey, Sydney R, Bergey, Dani E, Wheeler, Vanessa C, MacDonald, Marcy E, Baliga, Nitin S, Rosinski, Jim, Hood, Leroy E, Carroll, Jeffrey B, Price, Nathan D

“…Transcriptional changes occur presymptomatically and throughout Huntington's disease (HD), motivating the study of transcriptional regulatory networks (TRNs)…”
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