Search Results - "Seth, Arun K"

Global Transcriptome Analysis of Formalin-Fixed Prostate Cancer Specimens Identifies Biomarkers of Disease Recurrence by QI LONG, JIANPENG XU, STANIMIROVIC, Aleksandra, SETH, Arun K, PETROS, John A, MORENO, Carlos S, OSUNKOYA, Adeboye O, SANNIGRAHI, Soma, JOHNSON, Brent A, WEI ZHOU, GILLESPIE, Theresa, PARK, Jong Y, NAM, Robert K, SUGAR, Linda

“…Prostate cancer remains the second leading cause of cancer death in American men and there is an unmet need for biomarkers to identify patients with aggressive…”
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Protein-Coding and MicroRNA Biomarkers of Recurrence of Prostate Cancer Following Radical Prostatectomy by Long, Qi, Johnson, Brent A, Osunkoya, Adeboye O, Lai, Yu-Heng, Zhou, Wei, Abramovitz, Mark, Xia, Mingjing, Bouzyk, Mark B, Nam, Robert K, Sugar, Linda, Stanimirovic, Aleksandra, Williams, Daron J, Leyland-Jones, Brian R, Seth, Arun K, Petros, John A, Moreno, Carlos S

“…An important challenge in prostate cancer research is to develop effective predictors of tumor recurrence following surgery to determine whether immediate…”
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Regulation of Metformin Response by Breast Cancer Associated Gene 2 by Buac, Daniela, Kona, Fathima R, Seth, Arun K, Dou, Q. Ping

“…Abstract Adenosine monophosphate-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis, has emerged as a promising molecular…”
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Essential roles of IGFBP-3 and IGFBP-rP1 in breast cancer by Burger, Angelika M., Leyland-Jones, Brian, Banerjee, Kris, Spyropoulos, Demetri D., Seth, Arun K.

“…Insulin and insulin-like growth factors (IGFs) have critical functions in growth regulatory signalling pathways. They are part of a tightly controlled network…”
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Effects of partner proteins on BCA2 RING ligase activity by Bacopulos, Stephanie, Amemiya, Yutaka, Yang, Wenyi, Zubovits, Judit, Burger, Angelika, Yaffe, Martin, Seth, Arun K

“…BCA2 is an E3 ligase linked with hormone responsive breast cancers. We have demonstrated previously that the RING E3 ligase BCA2 has autoubiquitination…”
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Novel RING E3 Ubiquitin Ligases in Breast Cancer by Burger, Angelika, Amemiya, Yutaka, Kitching, Richard, Seth, Arun K.

“…Defects in ubiquitin E3 ligases are implicated in the pathogenesis of several human diseases, including cancer, because of their central role in the control of…”
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Genetic and Expression Aberrations of E3 Ubiquitin Ligases in Human Breast Cancer by Chen, Ceshi, Seth, Arun K, Aplin, Andrew E

“…Recent studies revealed that E3 ubiquitin ligases play important roles in breast carcinogenesis. Clinical research studies have found that (epi)-genetic…”
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RNF115/BCA2 E3 Ubiquitin Ligase Promotes Breast Cancer Cell Proliferation through Targeting p21Waf1/Cip1 for Ubiquitin-Mediated Degradation by Wang, Zehua, Nie, Zhi, Chen, Wenlin, Zhou, Zhongmei, Kong, Qinghua, Seth, Arun K, Liu, Rong, Chen, Ceshi

“…Abstract The E3 ubiquitin ligase RING finger protein 115 (RNF115), also known as breast cancer-associated gene 2 (BCA2), has previously been reported to be…”
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IL-6 Enhances the Nuclear Translocation of DNA Cytosine-5-Methyltransferase 1 (DNMT1) via Phosphorylation of the Nuclear Localization Sequence by the AKT Kinase by Hodge, David R, Cho, Edward, Copeland, Terry D, Guszczynski, Tad, Yang, Eric, Seth, Arun K, Farrar, William L

“…The epigenetic programming of genomic DNA is accomplished, in part, by several DNA cytosine-5-methyltransferases that act by covalently modifying cytosines…”
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The ubiquitin-mediated protein degradation pathway in cancer: therapeutic implications by Burger, Angelika M., Seth, Arun K.

“…The highly conserved eukaryotic ubiquitin–proteasome system (UP-S) plays a pivotal role in protein homeostasis and is critical in regulating normal and…”
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Role of the BCA2 ubiquitin E3 ligase in hormone responsive breast cancer by Burger, Angelika M, Kona, Fathima, Amemiya, Yutaka, Gao, Yuguang, Bacopulos, Stephanie, Seth, Arun K

“…The BCA2 protein contains a RING H2 finger and a Zn finger near the N-terminus and has E3 ligase activity. RING finger proteins play critical roles in…”
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A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13- 15, a region subject to LOH and rearrangement in human carcinoma cell lines by JIONG ZHOU, NG, A. Y. N, TYMMS, M. J, JERMIIN, L. S, SETH, A. K, THOMAS, R. S, KOLA, I

“…The ETS transcription factors are a large family implicated in the control of cellular proliferation and tumorigenesis. In addition, chromosomal translocations…”
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A novel RING-type ubiquitin ligase Breast Cancer-Associated Gene 2 correlates with outcome in invasive breast cancer by BURGER, Angelika M, YUGUANG GAO, AMEMIYA, Yutaka, KAHN, Harriette J, KITCHING, Richard, YILI YANG, PING SUN, NAROD, Steven A, HANNA, Wedad M, SETH, Arun K

“…The RING finger family of proteins possess ubiquitin ligase activity and play pivotal roles in protein degradation and receptor-mediated endocytosis. In this…”
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The RING finger protein11 binds to Smad4 and enhances Smad4-dependant TGF-beta signalling by Azmi, Peter B, Seth, Arun K

“…In breast carcinomas, prolonged signalling through the TGF-beta receptor promotes latent tumour progression, metastasis and the epithelial-to-mesenchymal…”
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Abstract 3554: miR-139 is associated with improved prognosis in patients with localized prostate cancer by Benatar, Tania, Nam, Robert K., Kobylecky, Elizabeth, Amemiya, Yutaka, Seth, Arun K.

“…Abstract Background: We previously identified a panel of five miRNAs associated with biochemical recurrence and metastasis following prostatectomy based on…”
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Abstract 2522: MiRNA-652 induces neuroendocrine-like differentiation in LNCaP prostate cancer cells through decreased PP2A function by Benatar, Tania, Amemiya, Yutaka, Wallis, Christopher J., Sugar, Linda, Sherman, Christopher, Nam, Robert, Seth, Arun K.

“…Abstract Background: MicroRNA (miRNA) dysregulation has been shown to contribute to prostate cancer progression. Recently, we identified a panel of five miRNAs…”
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Abstract A079: MicroRNA-139 regulates prostate cancer aggressiveness by targeting IGF1R by Amemiya, Yutaka, Wallis, Christopher J., Benatar, Tania, Kobylecky, Elizabeth, Sugar, Linda, Sherman, Christopher, Nam, Robert, Seth, Arun K.

“…Abstract Background: Dysregulated microRNA (miRNA) expression has been implicated in prostate cancer progression. We previously identified a panel of five…”
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Investigating HER2 status and polysomy 17 in gastric adenocarcinoma using multiplex ligation-dependent probe amplification by Wang, Tao, Amemiya, Yutaka, Henry, Pauline, Seth, Arun K, Hanna, Wedad, Hsieh, Eugene T

“…Abstract only…”
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Regulation of Metformin Response by Breast Cancer Associated Gene 2123 by Buac, Daniela, Kona, Fathima R, Seth, Arun K, Dou, Q Ping

“…Adenosine monophosphate-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis, has emerged as a promising molecular target in the…”
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The RING Finger Protein11 Binds to Smad4 and Enhances Smad4-dependant TGF-β Signalling by PETER B. AZMI, ARUN K. SETH

“…Background: In breast carcinomas, prolonged signalling through the TGF-β receptor promotes latent tumour progression, metastasis and the…”
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