Search Results - "Setchell, Kenneth"

Equol: history, chemistry, and formation by Setchell, Kenneth D R, Clerici, Carlo

“…Equol, first isolated from equine urine in 1932 and identified 50 years later in human urine as a metabolite of the soy isoflavones, daidzin and daidzein, is…”
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Equol: pharmacokinetics and biological actions by Setchell, Kenneth D R, Clerici, Carlo

“…Equol [7-hydroxy-3-(4'-hydroxyphenyl)-chroman], an isoflavan produced by intestinal bacteria in response to soy isoflavone intake in some but not all humans,…”
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Method of defining equol-producer status and its frequency among vegetarians by Setchell, Kenneth D R, Cole, Sidney J

“…7-Hydroxy-3-(4'-hydroxyphenyl)-chroman (S-equol) is a specific end-metabolite formed in the biotransformation of the dietary soy isoflavones daidzin and…”
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The history and basic science development of soy isoflavones by Setchell, Kenneth D.R

“…ABSTRACTThis review summarizes the 2016 NAMS/Pfizer—Wulf H. Utian Endowed Lecture that focused on the history and basic science of soy isoflavones. Described…”
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Pharmacological inhibition of apical sodium‐dependent bile acid transporter changes bile composition and blocks progression of sclerosing cholangitis in multidrug resistance 2 knockout mice by Miethke, Alexander G., Zhang, Wujuan, Simmons, Julia, Taylor, Amy E., Shi, Tiffany, Shanmukhappa, Shiva Kumar, Karns, Rebekah, White, Shana, Jegga, Anil G., Lages, Celine S., Nkinin, Stephenson, Keller, Bradley T., Setchell, Kenneth D.R.

“…Deficiency of multidrug resistance 2 (mdr2), a canalicular phospholipid floppase, leads to excretion of low‐phospholipid “toxic” bile causing progressive…”
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Efficacy and safety of maralixibat treatment in patients with Alagille syndrome and cholestatic pruritus (ICONIC): a randomised phase 2 study by Gonzales, Emmanuel, Hardikar, Winita, Stormon, Michael, Baker, Alastair, Hierro, Loreto, Gliwicz, Dorota, Lacaille, Florence, Lachaux, Alain, Sturm, Ekkehard, Setchell, Kenneth D R, Kennedy, Ciara, Dorenbaum, Alejandro, Steinmetz, Jana, Desai, Nirav K, Wardle, Andrew J, Garner, Will, Vig, Pamela, Jaecklin, Thomas, Sokal, Etienne M, Jacquemin, Emmanuel

“…Alagille syndrome is a rare genetic disease that often presents with severe cholestasis and pruritus. There are no approved drugs for management. Maralixibat,…”
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Open‐label Phase 3 Continuation Study of Cholic Acid in Patients With Inborn Errors of Bile Acid Synthesis by Heubi, James E., Setchell, Kenneth D.R.

“…ABSTRACT Background: In patients with bile acid synthesis disorders (BASD), impairment in the primary bile acid synthetic pathway leads to reduced primary bile…”
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Oral Cholic Acid Is Efficacious and Well Tolerated in Patients With Bile Acid Synthesis and Zellweger Spectrum Disorders by Heubi, James E., Bove, Kevin E., Setchell, Kenneth D.R.

“…ABSTRACT Objectives: Patients with bile acid synthesis disorders (BASDs) due to single enzyme defects (SEDs) or Zellweger spectrum disorders (ZSDs) accumulate…”
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Inhibition of ileal bile acid uptake protects against nonalcoholic fatty liver disease in high-fat diet-fed mice by Rao, Anuradha, Kosters, Astrid, Mells, Jamie E, Zhang, Wujuan, Setchell, Kenneth D R, Amanso, Angelica M, Wynn, Grace M, Xu, Tianlei, Keller, Brad T, Yin, Hong, Banton, Sophia, Jones, Dean P, Wu, Hao, Dawson, Paul A, Karpen, Saul J

“…Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the Western world, and safe and effective therapies are needed. Bile acids…”
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Urinary sphingolipids in adolescents and young adults with youth-onset diabetes by Nehus, Edward J., Sheanon, Nicole M., Zhang, Wujuan, Marcovina, Santica M., Setchell, Kenneth D. R., Mitsnefes, Mark M.

“…Background This study evaluated urinary sphingolipids as a marker of diabetic kidney disease (DKD) in adolescents and young adults with youth-onset type 1 and…”
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The clinical importance of the metabolite equol-a clue to the effectiveness of soy and its isoflavones by Setchell, Kenneth D R, Brown, Nadine M, Lydeking-Olsen, Eva

“…Equol [7-hydroxy-3-(4'-hydroxyphenyl)-chroman] is a nonsteroidal estrogen of the isoflavone class. It is exclusively a product of intestinal bacterial…”
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Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer risk by DR SETCHELL, Kenneth, BROWN, Nadine M, XUEHENG ZHAO, LINDLEY, Stephanie L, HEUBI, James E, KING, Eileen C, MESSINA, Mark J

“…Human and animal studies have produced conflicting results with regard to the effect of soy isoflavones on breast cancer risk. This may be due to differences…”
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Properties of neurons derived from induced pluripotent stem cells of Gaucher disease type 2 patient fibroblasts: potential role in neuropathology by Sun, Ying, Florer, Jane, Mayhew, Christopher N, Jia, Zhanfeng, Zhao, Zhiying, Xu, Kui, Ran, Huimin, Liou, Benjamin, Zhang, Wujuan, Setchell, Kenneth D R, Gu, Jianguo, Grabowski, Gregory A

“…Gaucher disease (GD) is caused by insufficient activity of acid β-glucosidase (GCase) resulting from mutations in GBA1. To understand the pathogenesis of the…”
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Farnesoid X receptor antagonizes macrophage-dependent licensing of effector T lymphocytes and progression of sclerosing cholangitis by Shi, Tiffany, Malik, Astha, Yang Vom Hofe, Annika, Matuschek, Louis, Mullen, Mary, Lages, Celine S, Kudira, Ramesh, Singh, Ruchi, Zhang, Wujuan, Setchell, Kenneth D R, Hildeman, David, Pasare, Chandrashekhar, Wagner, Brandee, Miethke, Alexander G

“…Immune-mediated bile duct epithelial injury and toxicity of retained hydrophobic bile acids drive disease progression in fibrosing cholangiopathies such as…”
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Bile Acid Profiling Reveals Distinct Signatures in Undernourished Children with Environmental Enteric Dysfunction by Zhao, Xueheng, Setchell, Kenneth D R, Huang, Rong, Mallawaarachchi, Indika, Ehsan, Lubaina, Dobrzykowski Iii, Edward, Zhao, Junfang, Syed, Sana, Ma, Jennie Z, Iqbal, Najeeha T, Iqbal, Junaid, Sadiq, Kamran, Ahmed, Sheraz, Haberman, Yael, Denson, Lee A, Ali, Syed Asad, Moore, Sean R

“…Intestinal inflammation and malabsorption in environmental enteric dysfunction (EED) are associated with early childhood growth faltering in impoverished…”
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Inborn Errors of Bile Acid Metabolism by Heubi, James E., MD, Setchell, Kenneth D.R., PhD, Bove, Kevin E., MD

“…Inborn errors of bile acid metabolism are rare causes of neonatal cholestasis and liver disease in older children and adults. The diagnosis should be…”
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Weight Loss Induced by Roux-en-Y Gastric Bypass But Not Laparoscopic Adjustable Gastric Banding Increases Circulating Bile Acids by Kohli, Rohit, Bradley, David, Setchell, Kenneth D, Eagon, J. Christopher, Abumrad, Nada, Klein, Samuel

“…Context: It has been hypothesized that increased plasma bile acids (BAs) contribute to metabolic improvements after Roux-en-Y gastric bypass (RYGB) surgery by…”
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Phytosterols promote liver injury and Kupffer cell activation in parenteral nutrition-associated liver disease by El Kasmi, Karim C, Anderson, Aimee L, Devereaux, Michael W, Vue, Padade M, Zhang, Wujuan, Setchell, Kenneth D R, Karpen, Saul J, Sokol, Ronald J

“…Parenteral nutrition-associated liver disease (PNALD) is a serious complication of PN in infants who do not tolerate enteral feedings, especially those with…”
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PGRN deficiency exacerbates, whereas a brain penetrant PGRN derivative protects, GBA1 mutation-associated pathologies and diseases by Zhao, Xiangli, Lin, Yi, Liou, Benjamin, Fu, Wenyu, Jian, Jinlong, Fannie, Venette, Zhang, Wujuan, Setchell, Kenneth D R, Grabowski, Gregory A, Sun, Ying, Liu, Chuan-Ju

“…Mutations in , encoding glucocerebrosidase (GCase), cause Gaucher disease (GD) and are also genetic risks in developing Parkinson's disease (PD). Currently,…”
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Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight‐loss‐independent manner by Myronovych, Andriy, Kirby, Michelle, Ryan, Karen K., Zhang, Wujuan, Jha, Pinky, Setchell, Kenneth DR, Dexheimer, Phillip J., Aronow, Bruce, Seeley, Randy J., Kohli, Rohit

“…Objective Our objective was to investigate the role of bile acids in hepatic steatosis reduction after vertical sleeve gastrectomy (VSG). Design and Methods…”
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