Search Results - "Sessions, Richard B."

Neuropilin-1 is a host factor for SARS-CoV-2 infection by Daly, James L, Simonetti, Boris, Klein, Katja, Chen, Kai-En, Williamson, Maia Kavanagh, Antón-Plágaro, Carlos, Shoemark, Deborah K, Simón-Gracia, Lorena, Bauer, Michael, Hollandi, Reka, Greber, Urs F, Horvath, Peter, Sessions, Richard B, Helenius, Ari, Hiscox, Julian A, Teesalu, Tambet, Matthews, David A, Davidson, Andrew D, Collins, Brett M, Cullen, Peter J, Yamauchi, Yohei

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), uses the viral spike (S) protein for…”
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On the Calculation of Acyl Chain Order Parameters from Lipid Simulations by Piggot, Thomas J, Allison, Jane R, Sessions, Richard B, Essex, Jonathan W

“…For molecular dynamics simulations of biological membrane systems to live up to the potential of providing accurate atomic level detail into membrane…”
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Self-Assembling Cages from Coiled-Coil Peptide Modules by Fletcher, Jordan M., Harniman, Robert L., Barnes, Frederick R. H., Boyle, Aimee L., Collins, Andrew, Mantell, Judith, Sharp, Thomas H., Antognozzi, Massimo, Booth, Paula J., Linden, Noah, Miles, Mervyn J., Sessions, Richard B., Verkade, Paul, Woolfson, Derek N.

“…An ability to mimic the boundaries of biological compartments would improve our understanding of self-assembly and provide routes to new materials for the…”
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Interaction of the antimicrobial peptide polymyxin B1 with both membranes of E. coli: a molecular dynamics study by Berglund, Nils A, Piggot, Thomas J, Jefferies, Damien, Sessions, Richard B, Bond, Peter J, Khalid, Syma

“…Antimicrobial peptides are small, cationic proteins that can induce lysis of bacterial cells through interaction with their membranes. Different mechanisms for…”
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unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer by Gallon, Matthew, Clairfeuille, Thomas, Steinberg, Florian, Mas, Caroline, Ghai, Rajesh, Sessions, Richard B, Teasdale, Rohan D, Collins, Brett M, Cullen, Peter J

“…The sorting nexin 27 (SNX27)-retromer complex is a major regulator of endosome-to-plasma membrane recycling of transmembrane cargos that contain a PSD95, Dlg1,…”
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Antiproliferative and Antimigratory Effects of a Novel YAP–TEAD Interaction Inhibitor Identified Using in Silico Molecular Docking by Smith, Sarah A, Sessions, Richard B, Shoemark, Deborah K, Williams, Christopher, Ebrahimighaei, Reza, McNeill, Madeleine C, Crump, Matthew P, McKay, Tristan R, Harris, Gemma, Newby, Andrew C, Bond, Mark

“…The Hippo pathway is an important regulator of cell growth, proliferation, and migration. TEAD transcription factors, which lie at the core of the Hippo…”
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Identification of key binding site residues of MCT1 for AR-C155858 reveals the molecular basis of its isoform selectivity by Nancolas, Bethany, Sessions, Richard B, Halestrap, Andrew P

“…The proton-linked monocarboxylate transporters (MCTs) are required for lactic acid transport into and out of all mammalian cells. Thus, they play an essential…”
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Cryo-EM of multiple cage architectures reveals a universal mode of clathrin self-assembly by Morris, Kyle L., Jones, Joseph R., Halebian, Mary, Wu, Shenping, Baker, Michael, Armache, Jean-Paul, Avila Ibarra, Amaurys, Sessions, Richard B., Cameron, Alexander D., Cheng, Yifan, Smith, Corinne J.

“…Clathrin forms diverse lattice and cage structures that change size and shape rapidly in response to the needs of eukaryotic cells during clathrin-mediated…”
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Construction and in vivo assembly of a catalytically proficient and hyperthermostable de novo enzyme by Watkins, Daniel W., Jenkins, Jonathan M. X., Grayson, Katie J., Wood, Nicola, Steventon, Jack W., Le Vay, Kristian K., Goodwin, Matthew I., Mullen, Anna S., Bailey, Henry J., Crump, Matthew P., MacMillan, Fraser, Mulholland, Adrian J., Cameron, Gus, Sessions, Richard B., Mann, Stephen, Anderson, J. L. Ross

“…Although catalytic mechanisms in natural enzymes are well understood, achieving the diverse palette of reaction chemistries in re-engineered native proteins…”
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CCBuilder: an interactive web-based tool for building, designing and assessing coiled-coil protein assemblies by Wood, Christopher W, Bruning, Marc, Ibarra, Amaurys Á, Bartlett, Gail J, Thomson, Andrew R, Sessions, Richard B, Brady, R Leo, Woolfson, Derek N

“…The ability to accurately model protein structures at the atomistic level underpins efforts to understand protein folding, to engineer natural proteins…”
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Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules by van Weering, Jan R T, Sessions, Richard B, Traer, Colin J, Kloer, Daniel P, Bhatia, Vikram K, Stamou, Dimitrios, Carlsson, Sven R, Hurley, James H, Cullen, Peter J

“…Sorting nexins (SNXs) are regulators of endosomal sorting. For the SNX‐BAR subgroup, a Bin/Amphiphysin/Rvs (BAR) domain is vital for formation/stabilization of…”
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Beyond icosahedral symmetry in packings of proteins in spherical shells by Mosayebi, Majid, Shoemark, Deborah K., Fletcher, Jordan M., Sessions, Richard B., Linden, Noah, Woolfson, Derek N., Liverpool, Tanniemola B.

“…The formation of quasi-spherical cages from protein building blocks is a remarkable self-assembly process in many natural systems, where a small number of…”
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Biophysical characterization of the ETV6 PNT domain polymerization interfaces by Gerak, Chloe A.N., Cho, Sophia Y., Kolesnikov, Maxim, Okon, Mark, Murphy, Michael E.P., Sessions, Richard B., Roberge, Michel, McIntosh, Lawrence P.

“…ETV6 is an E26 transformation specific family transcriptional repressor that self-associates by its PNT domain to facilitate cooperative DNA binding…”
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Cryo-transmission electron microscopy structure of a gigadalton peptide fiber of de novo design by Sharp, Thomas H, Bruning, Marc, Mantell, Judith, Sessions, Richard B, Thomson, Andrew R, Zaccai, Nathan R, Brady, R. Leo, Verkade, Paul, Woolfson, Derek N

“…Nature presents various protein fibers that bridge the nanometer to micrometer regimes. These structures provide inspiration for the de novo design of…”
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Bioinformatic analysis of meningococcal Msf and Opc to inform vaccine antigen design by Andreae, Clio A, Sessions, Richard B, Virji, Mumtaz, Hill, Darryl J

“…Neisseria meningitidis is an antigenically and genetically variable Gram-negative bacterium and a causative agent of meningococcal meningitis and septicaemia…”
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Squaring the Circle in Peptide Assembly: From Fibers to Discrete Nanostructures by de Novo Design by Boyle, Aimee L, Bromley, Elizabeth H. C, Bartlett, Gail J, Sessions, Richard B, Sharp, Thomas H, Williams, Claire L, Curmi, Paul M. G, Forde, Nancy R, Linke, Heiner, Woolfson, Derek N

“…The design of bioinspired nanostructures and materials of defined size and shape is challenging as it pushes our understanding of biomolecular assembly to its…”
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The Lysozyme Inhibitor Thionine Acetate Is Also an Inhibitor of the Soluble Lytic Transglycosylase Slt35 from Escherichia coli by Mezoughi, Aysha B., Costanzo, Chiara M., Parker, Gregor M., Behiry, Enas M., Scott, Alan, Wood, Andrew C., Adams, Sarah E., Sessions, Richard B., Loveridge, E. Joel

“…Lytic transglycosylases such as Slt35 from E. coli are enzymes involved in bacterial cell wall remodelling and recycling, which represent potential targets for…”
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Studies on the DIDS-binding Site of Monocarboxylate Transporter 1 Suggest a Homology Model of the Open Conformation and a Plausible Translocation Cycle by Wilson, Marieangela C., Meredith, David, Bunnun, Chotirote, Sessions, Richard B., Halestrap, Andrew P.

“…Site-directed mutagenesis of MCT1 was performed on exofacial lysines Lys38, Lys45, Lys282, and Lys413. K38Q-MCT1 and K38R-MCT1 were inactive when expressed at…”
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Three‐dimensional electron microscopy reconstruction and cysteine‐mediated crosslinking provide a model of the type III secretion system needle tip complex by Cheung, Martin, Shen, Da‐Kang, Makino, Fumiaki, Kato, Takayuki, Roehrich, A. Dorothea, Martinez‐Argudo, Isabel, Walker, Matthew L., Murillo, Isabel, Liu, Xia, Pain, Maria, Brown, James, Frazer, Gordon, Mantell, Judith, Mina, Petros, Todd, Thomas, Sessions, Richard B., Namba, Keiichi, Blocker, Ariel J.

“…Summary Type III secretion systems are found in many Gram‐negative bacteria. They are activated by contact with eukaryotic cells and inject virulence proteins…”
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In Silico-Guided Rational Drug Design and Semi-synthesis of C(2)-Functionalized Huperzine A Derivatives as Acetylcholinesterase Inhibitors by Anukanon, Shisanupong, Pongpamorn, Pornkanok, Tiyabhorn, Wareepat, Chatwichien, Jaruwan, Niwetmarin, Worawat, Sessions, Richard B, Ruchirawat, Somsak, Thasana, Nopporn

“…Huperzine A (1, Hup A), a lycodine-type Lycopodium alkaloid isolated from Thai clubmosses Huperzia squarrosa (G. Forst.) Trevis., H. carinata (Desv. ex. Poir.)…”
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