Search Results - "Sessa, W C"

Thrombospondin-2 regulates extracellular matrix production, LOX levels, and cross-linking via downregulation of miR-29 by Calabro, N.E., Barrett, A., Chamorro-Jorganes, A., Tam, S., Kristofik, N.J., Xing, Hao, Loye, Ayomiposi M., Sessa, W.C., Hansen, K., Kyriakides, T.R.

“…Collagen fibrillogenesis and crosslinking have long been implicated in extracellular matrix (ECM)-dependent processes such as fibrosis and scarring. However,…”
Get full text

Impaired endothelial nitric oxide synthase activity associated with enhanced caveolin binding in experimental cirrhosis in the rat by SHAH, V, TORUNER, M, HADDAD, F, CADELINA, G, PAPAPETROPOULOS, A, CHOO, K, SESSA, W. C, GROSZMANN, R. J

“…Background & Aims: A reduction in nitric oxide (NO) has been implicated as a cause of intrahepatic vasoconstriction in cirrhosis, but the regulatory mechanisms…”
Get full text

Dynamic activation of endothelial nitric oxide synthase by Hsp90 by Sessa, William C, García-Cardeña, Guillermo, Fan, Roger, Shah, Vijay, Sorrentino, Raffaella, Cirino, Giuseppe, Papapetropoulos, Andreas

“…Heat-shock protein 90 (Hsp90) coordinates the trafficking and regulation of diverse signalling proteins, but its precise role in regulating specific cellular…”
Get full text

Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells by Papapetropoulos, A, García-Cardeña, G, Madri, J A, Sessa, W C

“…Vascular endothelial growth factor (VEGF) is a regulator of vasculogenesis and angiogenesis. To investigate the role of nitric oxide (NO) in VEGF-induced…”
Get full text

Chronic Exercise in Dogs Increases Coronary Vascular Nitric Oxide Production and Endothelial Cell Nitric Oxide Synthase Gene Expression by Sessa, William C, Pritchard, Kirkwood, Seyedi, Nahid, Wang, Jie, Hintze, Thomas H

“…Recently, we have shown that chronic exercise increases endothelium-derived relaxing factor (EDRF)/nitric oxide (NO)-mediated epicardial coronary artery…”
Get full text

Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling by Rudic, R D, Shesely, E G, Maeda, N, Smithies, O, Segal, S S, Sessa, W C

“…The vascular endothelium mediates the ability of blood vessels to alter their architecture in response to hemodynamic changes; however, the specific…”
Get full text

Vascular Endothelial Growth Factor-Stimulated Actin Reorganization and Migration of Endothelial Cells Is Regulated via the Serine/Threonine Kinase Akt by Morales-Ruiz, Manuel, Fulton, David, Sowa, Grzegorz, Languino, Lucia R, Fujio, Yasushi, Walsh, Kenneth, Sessa, William C

“…Vascular endothelial growth factor (VEGF) induces endothelial cell proliferation, migration, and actin reorganization, all necessary components of an…”
Get full text

Nitric oxide synthases: regulation and function by FDRSTERMANN, Ulrich, SESSA, William C

“…Nitric oxide (NO), the smallest signalling molecule known, is produced by three isoforms of NO synthase (NOS; EC 1.14.13.39). They all utilize l-arginine and…”
Get full text

Biological action of leptin as an angiogenic factor by Sierra-Honigmann, M.R. (Yale University School of Medicine, New Haven, CT.), Nath, A.K, Murakami, C, Garcia-Cardena, G, Papapetropoulos, A, Sessa, W.C, Madge, L.A, Schechner, J.S, Schwabb, M.B, Polverini, P.J

“…Leptin is a hormone that regulates food intake, and its receptor (OB-Rb) is expressed primarily in the hypothalamus. Here, it is shown that OB-Rb is also…”
Get full text

Direct actions of angiopoietin-1 on human endothelium: evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors by Papapetropoulos, A, García-Cardeña, G, Dengler, T J, Maisonpierre, P C, Yancopoulos, G D, Sessa, W C

“…Angiopoietin-1 (Ang-1) is a recently described angiogenic protein that activates the endothelial Tie 2 receptor. Disruption of the Ang-1 gene shows that it has…”
Get more information

Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells : elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity by ROSENKRANZ-WEISS, P, SESSA, W. C, MILSTIEN, S, KAUFMAN, S, WATSON, C. A, POBER, J. S

“…We have examined cytokine regulation of nitric oxide synthase (NOS) in human umbilical vein endothelial cells (HUVEC). 24-h treatment with IFN-gamma (200 U/ml)…”
Get full text

Targeting of Nitric Oxide Synthase to Endothelial Cell Caveolae Via Palmitoylation: Implications for Nitric Oxide Signaling by García-Cardeña, Guillermo, Oh, Phil, Liu, Jianwei, Schnitzer, Jan E., Sessa, William C.

“…The membrane association of endothelial nitric oxide synthase (eNOS) plays an important role in the biosynthesis of nitric oxice (NO) in vascular endothelium…”
Get full text

Involvement of nitric oxide in the reflex relaxation of the stomach to accommodate food or fluid by Desai, K. M, Sessa, W. C, Vane, J. R

“…The fundus of the guinea-pig stomach actively dilates in response to low increases in intragastric pressure. This physiological response, now called adaptive…”
Get full text

Molecular control of blood flow and angiogenesis: role of nitric oxide by SESSA, W. C.

“…In the past decade, the importance of the vascular endothelium as a multifunctional regulator of vascular smooth muscle physiology and pathophysiology has been…”
Get full text

The nitric oxide synthase family of proteins by Sessa, W C

“…Nitric oxide (NO) is an important bio-regulatory molecule in the nervous, immune and cardiovascular systems. NO is synthesized from one of the guanidino…”
Get more information

Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase by SESSA, W. C, HARRISON, J. K, BARBER, C. M, ZENG, D, DURIEUX, M. E, D'ANGELO, D. D, LYNCH, K. R, PEACH, M. J

“…Endothelium-derived relaxing factor (EDRF), identified as nitric oxide (NO), is derived from a guanidino nitrogen of L-arginine via its metabolism by nitric…”
Get full text

Effective treatment of vascular endothelial growth factor refractory hindlimb ischemia by a mutant endothelial nitric oxide synthase gene by QIAN, H. S, LIU, P, SZYMANSKI, P, VERGONA, R, HARKINS, R, YU, J, SESSA, W. C, DOLE, W. P, RUBANYI, G. M, KAUSER, K, HUW, L.-Y, ORME, A, HALKS-MILLER, M, HILL, S. M, JIN, F, KRETSCHMER, P, BLASKO, E, CASHION, L

“…Gene delivery of angiogenic growth factors is a promising approach for the treatment of ischemic cardiovascular diseases. However, success of this new…”
Get full text

Gene Transduction of an Active Mutant of Akt Exerts Cytoprotection and Reduces Graft Injury After Liver Transplantation by Morales‐Ruiz, M., Fondevila, C., Muñoz‐Luque, J., Tugues, S., Rodríguez‐Laiz, G., Cejudo‐Martín, P., Romero, J. M., Navasa, M., Fuster, J., Arroyo, V., Sessa, W. C., García‐Valdecasas, J. C., Jiménez, W.

“…Akt is expected to be an effective target for the treatment of ischemia‐reperfusion injury (I/R) due to its anti‐apoptotic properties and its ability to…”
Get full text

Bacterial infection induces nitric oxide synthase in human neutrophils by Wheeler, M A, Smith, S D, García-Cardeña, G, Nathan, C F, Weiss, R M, Sessa, W C

“…The identification of human inflammatory cells that express inducible nitric oxide synthase and the clarification of the role of inducible nitric oxide…”
Get full text

Native Low-Density Lipoprotein Increases Endothelial Cell Nitric Oxide Synthase Generation of Superoxide Anion by Pritchard, Kirkwood A, Groszek, Laura, Smalley, David M, Sessa, William C, Wu, Mingdan, Villalon, Patricio, Wolin, Michael S, Stemerman, Michael B

“…To examine mechanisms by which native lowdensity lipoprotein (n-LDL) perturbs endothelial cell (EC) release of superoxide anion (O2) and nitric oxide (NO), ECs…”
Get full text